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The Action of Ipecacuanha Alkaloids on Entamoeba histolytica and some other Entozoic Amoebae in Culture

Published online by Cambridge University Press:  06 April 2009

Clifford Dobell  and
P. P. Laidlaw
Clifford Dobell
Affiliation:
National Institute for Medical Research, London, N.W. 3.
P. P. Laidlaw
Affiliation:
National Institute for Medical Research, London, N.W. 3.
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Extract

It is now recognized, by all competent observers, that emetine is a specific therapeutic agent for the treatment of amoebic dysentery; but although it is known that a thorough course of emetine, in some form, will eradicate an infection with Entamoeba histolytica from most human beings, there is still complete ignorance as to how the cure is effected. The obvious hypothesis, that emetine is a specific poison for E. histolytica, has not hitherto been supported by adequate experimental evidence. It is true that observers have described experiments in which the alkaloid, in high dilution, has apparently killed various amoebae in vitro; but these experiments either ignored the peculiarly specific action of emetine in vivo on E. histolytica, or were carried out without adequate controls.

Type
Research Article
Information
Parasitology , Volume 18 , Issue 2 , June 1926 , pp. 206 - 223
Copyright
Copyright © Cambridge University Press 1926

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