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Accelerated expulsion of adult Trichinella spiralis in mice given lymphoid cells and serum from infected donors

Published online by Cambridge University Press:  06 April 2009

D. Wakelin  and
M. Lloyd
D. Wakelin
Affiliation:
Wellcome Laboratories for Experimental Parasitology, University of Glasgow, Bearsden Road, Glasgow, G61 1QH
M. Lloyd
Affiliation:
Wellcome Laboratories for Experimental Parasitology, University of Glasgow, Bearsden Road, Glasgow, G61 1QH
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Summary

Immunity to the adult stage of Trichinella spiralis, assessed by an acceleration of worm expulsion, was transferred to recipient mice with mesenteric lymph node cells (MLNC) or serum taken from infected donors. Immunity was transferred most effectively by MLNC taken from donors infected for 8 days, i.e. donors actively responding to infection. Transfer of both MLNC and serum brought about a marked acceleration of worm expulsion in all cases, even where MLNC or serum given separately failed to transfer a significant degree of immunity.

Type
Research Article
Information
Parasitology , Volume 72 , Issue 3 , June 1976 , pp. 307 - 315
Copyright
Copyright © Cambridge University Press 1976

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References

Crowle, A. J., (1975). Delayed hypersensitivity in the mouse. Advances in Immunology 20, 197–263.CrossRefGoogle ScholarPubMed
Culberson, J. T., (1942). Passive transfer of immunity to Trichinella spiralis in the rat. Journal of Parasitology 28, 203–6.CrossRefGoogle Scholar
Culbertson, J. T., (1943). Natural transmission of immunity against Trichinella spiralis from mother rats to their offspring. Journal of Parasitology 29, 114–6.CrossRefGoogle Scholar
Culbertson, J. R., & Kaplan, S. S., (1938). A study upon passive immunity in experimental trichiniasis. Parasitology 30, 156–66.CrossRefGoogle Scholar
Denham, D. A., (1969). Immunity of Trichinella spiralis IV. Passive immunity in mice. Folia Parasitologica 16, 183–7.Google Scholar
Dineen, J. K., & Wagland, B. M., (1966). The cellular transfer of immunity to Trichostrongylus colubriformis in an isogenic strain of guinea-pig. II. The relative susceptibility of the larval and adult stages of the parasite to immunological attack. Immunology 11, 47–57.Google Scholar
Duckett, M. G., Denham, D. A., & Nelson, G. S., (1972). Immunity to Trichinella spiralis. V. Transfer of immunity against the intestinal phase from mother to baby mice. Journal of Parasitology 58, 550–4.CrossRefGoogle ScholarPubMed
Faubert, G., & Tanner, C. E., (1973). Enlargement of lymph nodes during infection with Trichinella spiralis: a preliminary histological study. In Trichinellosis (ed. Kim, C. W.), pp. 353–66. New York: Intext Educational Publishers.Google Scholar
Gore, R. W., Burger, H-J., & Sadun, E. H., (1973). Humoral and cellular factors in the resistance of rats to Trichinella spiralis In Trichinellosis (ed. Kim, C. W.), pp. 367–82. New York: Intext Educational Publishers.Google Scholar
Hendriks, J. R., (1953). Passive transfer of resistance to Trichinella spiralis in mice. Journal of Parasitology 39 (Sect. 2), 40–1.Google Scholar
Larsh, J. E. Jr, Goulson, H. T., & Weatherly, N. F., (1964 a). Studies on delayed (cellular) hypersensitivity in mice infected with Trichinella spiralis. I. Transfer of lymph node cells. Journal of the Elisha Mitchell Scientific Society 80, 133–5.Google Scholar
Larsh, J. E. Jr, Goulson, H. T., & Weatherly, N. F., (1964 b). Studies on delayed (cellular) hypersensitivity in mice infected with Trichinella spiralis. II. Transfer of peritoneal exudate cells. Journal of Parasitology 50, 496–8.CrossRefGoogle ScholarPubMed
Larsh, J. E. Jr, Goulson, H. T., Weatherly, N. F., & Chaffee, E. F., (1969). Studies on delayed (cellular) hypersensitivity in mice infected with Trichinella spiralis. IV, Artificial sensitization of donors. Journal of Parasitology 55, 726–9.CrossRefGoogle ScholarPubMed
Larsh, J. E. Jr, Goulson, H. T., Weatherly, N. F. & Chaffee, E. F., (1970). Studies on delayed (cellular) hypersensitivity in mice infected with Trichinella spiralis. V. Tests in recipients injected with donor spleen cells 1, 3, 7, 14 or 21 days before infection. Journal of Parasitology 56, 978–81.CrossRefGoogle ScholarPubMed
Labsh, J. E. Jr, & Race, G. J., (1975). Allergic inflammation as a hypothesis for the expulsion of worms from tissues: a review. Experimental Parasitology 37, 251–66.Google Scholar
Larsh, J. E. Jr, Race, G. J., Goulson, H. T., & Weatherly, N. F. (1966). Studies on delayed (cellular) hypersensitivity in mice infected with Trichinella spiralis. III. Serologic and histopathologic findings in recipients given peritoneal exudate cells. Journal of Parasitology 52, 146–56.CrossRefGoogle Scholar
Love, R. J., Ogilvee, B. M. & Mclaren, D. J. (1976). The immune mechanism which expels the intestinal stage of Trichinella spiralis from rats. Immunology 30, 7–16.Google ScholarPubMed
Mccoy, O. R. & Bond, F. F. (1941). Attempted passive transfer to rats and mice of immunity to Trichinella spiralis. Journal of Parasitology 27 (Suppl.), 24–5.Google Scholar
Mauss, E. A. (1940). Transmission of immunity to Trichinella spiralis from infected animals to their offspring. American Journal of Hygiene 32 (Sect. D), 75–9.Google Scholar
Mills, C. K. & Kent, N. H. (1965). Excretions and secretions of Trichinella spiralis and their role in immunity. Experimental Parasitology 16, 300–10.CrossRefGoogle ScholarPubMed
Ogilvie, B. M. & Jones, V. E. (1968). Passive protection with cells or antiserum against Nippostrongylus brasiliensis in the rat. Parasitology 55, 939–49.CrossRefGoogle Scholar
Ogilvie, B. M. & Love, R. J. (1974). Co-operation between antibodies and cells in immunity to a nematode parasite. Transplantation Reviews 19, 147–68.Google ScholarPubMed
Parrott, D. M. V. & Ferguson, A. (1974). Selective migration of lymphocytes within the mouse small intestine. Immunology 26, 571–88.Google ScholarPubMed
Perry, R. H. (1974). Transfer of immunity to Trichinella spiralis from mother to offspring. Journal of Parasitology 60, 460–5.CrossRefGoogle ScholarPubMed
Selby, G. R. & Wakelin, D. (1973). Transfer of immunity against Trichuris muris in the mouse by serum and cells. International Journal for Parasitology 3, 717–22.CrossRefGoogle ScholarPubMed
Sher, A., Smithebs, S. R. & Mackenzie, P. (1974). Passive transfer of acquired resistance to Schistosoma mansoni in laboratory mice. Parasitology 70, 347–57.CrossRefGoogle Scholar
Staroniewicz, Z. (1971). The influence of cell transfers from immunized animals on the course of trichinellosis in mice. Acta Parasitologica Polonica 19, 307–18.Google Scholar
Wakelin, D. (1975). Immune expulsion of Trichuris muris from mice during a primary infection: analysis of the components involved. Parasitology 70, 397–405.CrossRefGoogle ScholarPubMed
Wakelin, D. & Lloyd, M. (1976). Immunity to primary and challenge infections of Trichinella spiralis in mice: a reexamination of conventional parameters. Parasitology (in the Press).CrossRefGoogle Scholar