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Use of clomipramine as chemotherapy of the chronic phase of Chagas disease

Published online by Cambridge University Press:  27 March 2013

ROMINA FAURO ,
SILVINA LO PRESTI ,
CAROLINA BAZAN ,
ALEJANDRA BAEZ ,
MARIANA STRAUSS ,
FERNANDA TRIQUELL ,
DAVID CREMONEZZI ,
OLGA SANCHEZ NEGRETE ,
GASTON CAMINO WILLHUBER  and
PATRICIA PAGLINI-OLIVA
...Show all authors
ROMINA FAURO
Affiliation:
Cátedra de Parasitología y Micología Médicas, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Santa Rosa 1085, 5000 Córdoba, Argentina
SILVINA LO PRESTI
Affiliation:
Cátedra de Física Biomédica, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina Cátedra de Metodología de la Investigación Científica, Escuela de Kinesiología y Fisioterapia, Facultad de Ciencias Médicas Universidad Nacional de Córdoba, Córdoba, Argentina Cátedra de Biología Celular, Histología y Embriología, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina
CAROLINA BAZAN
Affiliation:
Cátedra de Física Biomédica, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina
ALEJANDRA BAEZ
Affiliation:
Cátedra de Física Biomédica, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina
MARIANA STRAUSS
Affiliation:
Cátedra de Física Biomédica, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina
FERNANDA TRIQUELL
Affiliation:
Cátedra de Biología Celular, Histología y Embriología, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina
DAVID CREMONEZZI
Affiliation:
Cátedra de Patología, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina
OLGA SANCHEZ NEGRETE
Affiliation:
Cátedra de Química Biológica, Facultad de Ciencias Exactas, Universidad Nacional de Salta, Salta, Argentina
GASTON CAMINO WILLHUBER
Affiliation:
Cátedra de Física Biomédica, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina
PATRICIA PAGLINI-OLIVA
Affiliation:
Cátedra de Física Biomédica, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina
HECTOR WALTER RIVAROLA*
Affiliation:
Cátedra de Física Biomédica, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina Cátedra de Física Biomédica, Escuela de Medicina, Universidad Nacional de La Rioja, La Rioja, Argentina
*
*Corresponding author: Corrientes 3525, San Vicente, 5006 Córdoba, Argentina. Tel: +54 351 4566122. E-mail: [email protected].
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Summary

Chagas infection is a major endemic disease affecting Latin American countries. The persistence of Trypanosoma cruzi generates a chronic inflammatory reactivity that induces an immune response directed to the host's tissues. The effectiveness of the treatment in the chronic phase is still unsatisfactory due, amongst other reasons, to the collateral effects of the drugs used. We investigated the effect of clomipramine, a tricyclic antidepressant that, when used as a treatment of T. cruzi-chronically infected mice, inhibits trypanothione reductase, an exclusive and vital enzyme of T. cruzi. Clomipramine improved survival (P<0·05) by diminishing the parasite intensity as demonstrated by PCR studies in the heart and skeletal muscle, and significantly prevented the evolution to fibrosis of the inflammatory infiltrates. Clomipramine could be a good candidate for the treatment of chronic Chagas disease.

Keywords

Chagas diseasetreatmenttrypanothione reductaseclomipraminecardiac chronic stage
Type
Research Article
Information
Parasitology , Volume 140 , Issue 7 , June 2013 , pp. 917 - 927
Copyright
Copyright © Cambridge University Press 2013 

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