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The uptake and incorporation of nucleosides into normal erythrocytes and erythrocytes containing Plasmodium berghei

Published online by Cambridge University Press:  06 April 2009

K. D. Neame ,
P. A. Brownbill  and
C. A. Homewood
K. D. Neame
Affiliation:
Departments of Physiology and Parasitology, University of Liverpool
P. A. Brownbill
Affiliation:
Departments of Physiology and Parasitology, University of Liverpool
C. A. Homewood
Affiliation:
Departments of Physiology and Parasitology, University of Liverpool
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Extract

Normal mouse erythrocytes and erythrocytes containing Plasmodium berghei were incubated for 1 h in a medium containing either adenosine, guanosine, cytidine or thymidine labelled with 14C or 3H. The purine nucleosides, adenosine and guanosine, but not the pyrimidine nucleosides, cytidine and thymidine, were incorporated into the nucleic acid of the parasite–host cell complex. The concentration achieved by all four nucleosides in both normal and parasitized cells was at least as high as that in the suspending medium, showing that not only purines but also pyrimidines enter the parasitized erythrocyte.

Type
Research Article
Information
Parasitology , Volume 69 , Issue 3 , December 1974 , pp. 329 - 335
Copyright
Copyright © Cambridge University Press 1974

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