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The ultrastructural development of the schistosome egg granuloma in mice

Published online by Cambridge University Press:  06 April 2009

Mary D. Smith
Mary D. Smith
Affiliation:
Department of Medical Helminthology, London School of Hygiene and Tropical Medicine, London WC1.
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Extract

Hepatic granulomas from mice infected with Schistosoma mansoni for periods of 8 weeks to 1 year were studied by electron microscopy. The different cell types present in the granulomas suggested that whilst a delayed hypersensitivity response predominated during early stages of infection an Arthus-type reaction associated with delayed hypersensi-tivity occurred at later stages of infection.

Type
Research Article
Information
Parasitology , Volume 75 , Issue 1 , August 1977 , pp. 119 - 123
Copyright
Copyright © Cambridge University Press 1977

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References

REFERENCES

Andrade, Z. A. (1965). Hepatic schistosomiasis. Morphological aspects. In Progress in Liver Diseases, Vol. 2 (ed. Popper, H. & Schaffner, F.), pp. 228–42. New York: Grune and Stratton.CrossRefGoogle Scholar
Andrade, Z. A. & Prata, A. (1963). Asymptomatic schistosomiasis studied by needle biopsy of the liver. American Journal of Tropical Medicine and Hygiene 12, 854–8.CrossRefGoogle ScholarPubMed
Andrade, Z. A. & Warren, K. S. (1964). Mild prolonged schistosomiasis in mice. Alterations in host response with time and the development of portal fibrosis. Transactions of the Royal Society of Tropical Medicine and Hygiene 58, 53–7.CrossRefGoogle ScholarPubMed
Andrade, Z. A., Paronetto, F. & Popper, H. (1961). Immunocytochemical studies in schistosomiasis. American Journal of Pathology 39, 589–98.Google ScholarPubMed
Gell, P. G. H. & Hinde, I. T. (1954). Observations on the histology of the Arthus reaction and its relation to other known types of skin hypersensitivity. International Archives of Allergy and Applied Immunology 5, 23–46.CrossRefGoogle ScholarPubMed
Gönnert, R. (1955). Schistosomiasis-studien 11: Über die Eibildung bei Schistosoma mansoni und das Schicksal der Eier im Wirtsorganismus. Zeitschrift für Tropenmedizin und Parasitologie 6, 33–52.Google Scholar
Lichtenberg, F. Von (1962). Host response to eggs of Schistosoma mansoni. I. Granuloma formation in the unsensitized laboratory mouse. American Journal of Pathology 41, 711–31.Google Scholar
Lichtenberg, F. Von (1967). The bilharzial pseudotubercle: a model of the immunopathology of granuloma formation. In Immunologogical Aspects of Parasitic Infections. Pan American Health Organization Scientific Publications 150, 107–20.Google Scholar
Luft, J. H. (1961). Improvements in Epoxy resin embedding methods. Journal of Biophysical and Biochemical Cytology 9, 409–14.CrossRefGoogle ScholarPubMed
Maldonado, J. F. (1959). The longevity of the unhatched miracidium of Schistosoma mansoni in the tissues of mice. American Journal of Tropical Medicine and Hygiene 8, 16–19.CrossRefGoogle ScholarPubMed
Movat, H. Z. & Fernando, N. V. P. (1965). The fine structure of the lymphoid tissue during antibody formation. Experimental and Molecular Pathology 4, 155–88.CrossRefGoogle ScholarPubMed
Stenger, R. J., Warren, K. S. & Johnson, E. A. (1967). An ultrastructural study of hepatic granulomas and schistosome egg shells in murine hepatosplenic schistosomiasis mansoni. Experimental and Molecular Pathology 7, 116–32.CrossRefGoogle ScholarPubMed