Hostname: page-component-78c5997874-s2hrs Total loading time: 0 Render date: 2024-11-20T04:42:47.986Z Has data issue: false hasContentIssue false
  • English
  • Français

Trypanosoma musculi: influence of uric acid on in vitro formation of metacyclic trypomastigotes

Published online by Cambridge University Press:  06 April 2009

M. Roger  and
P. Viens
M. Roger
Affiliation:
Département de Microbiologie et d'Immunologie, Université de Montréal, C.P. 6128, succursale ‘A’, Montréal, P.Q. H3C 3J7
P. Viens
Affiliation:
Département de Microbiologie et d'Immunologie, Université de Montréal, C.P. 6128, succursale ‘A’, Montréal, P.Q. H3C 3J7
Get access Rights & Permissions [Opens in a new window]

Summary

Uric acid is the most important constituent in the urine of insects. Infective metacyclic forms of the stercorarian trypanosomes are produced in the rectum of their insect vector and are thus in contact with uric acid. Using a culture system which permitted the growth of the insect stages of Trypanosoma musculi, we studied the influence of uric acid on the metacyclogenesis of this parasite. When added to the culture, uric acid enhanced the production of metacyclic forms. Furthermore, it rendered these trypanosomes highly infective by the oral route. It is suggested that uric acid may play an important role on the metacyclogenesis of T. musculi.

Type
Research Article
Information
Parasitology , Volume 95 , Issue 3 , December 1987 , pp. 531 - 535
Copyright
Copyright © Cambridge University Press 1987

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Hoare, C. A. (1964). Morphological and taxonomic studies on the mammalian trypanosomes. X. Revision of systematics. Journal of Protozoology 11, 200–7.CrossRefGoogle ScholarPubMed
Hoare, C. A. (1972). The Trypanosomes of Mammals. A Zoological Monograph. Oxford and Edinburgh: Blackwell Scientific Publications.Google Scholar
Krampitz, H. E. (1969). Verbreitung, Wirt-Partazit-Beziehungen und Vermehrung sizilianischer Stamme von Trypanosoma (Herpetosoma) duttoni Thiroux 1905 (Protozoa, Trypanosomatidae). Zeitschrift für Parasitenkunde 32, 297–315.CrossRefGoogle ScholarPubMed
Lumsden, W. H. R. (1972). Principles of viable preservation of parasitic protozoa. International Journal for Parasitology 2, 327–32.CrossRefGoogle ScholarPubMed
Minchin, E. A. & Thomson, J. D. (1915). The rat-trypanosome, Trypanosoma lewisi, in its relation to the rat-flea, Ceratophyllus fasciatus. Quarterly Journal of Microscopic Science 60, 463–92.Google Scholar
Molyneux, D. H. (1969). The morphology and life-history of Trypanosoma (Herpetosoma) microti of the field-vole, Microtus agrestis. Annals of Tropical Medicine and Parasitology 63, 229–44.CrossRefGoogle ScholarPubMed
Molyneux, D. H. (1970). Developmental patterns in trypanosomes of the subgenus Herpetosoma. Annales de la Société Belge de Médecine Tropicale 50, 229–38.Google ScholarPubMed
Pereira, M. E. A., Andrade, A. F. B. & Ribeiro, J. M. C. (1981). Lectins of distinct specificity in Rhodnius prolixus interact selectively with Trypanosoma cruzi. Science 211, 597–9.CrossRefGoogle ScholarPubMed
Roger, M. & Viens, P. (1986). In vitro production of metacyclic forms of Trypanosoma musculi and their infectivity in CBA mice. Journal of Protozoology 33, 87–9.CrossRefGoogle ScholarPubMed
Sher, A. & Snary, D. (1982). Specific inhibition of the morphogenesis of Trypanosoma cruzi by a monoclonal antibody. Nature, London 300, 639–40.CrossRefGoogle ScholarPubMed
Viens, P., Targett, G. A. T., Leuchars, E. & Davies, A. J. S. (1974). The immunological response of CBA mice to Trypanosoma musculi. I. Initial control of the infection and the effect of T-cell deprivation. Clinical and Experimental Immunology 16, 279–94.Google ScholarPubMed
Wigglesworth, V. B. (1931). The physiology of excretion in a blood-sucking insect, Rhodnius prolixus (Hemiptera, Reduviidae). I. Composition of the urine. Journal of Experimental Biology 8, 411–27.CrossRefGoogle Scholar
Zeledon, R., Alvarado, R. & Jiron, L. F. (1977). Observation on the feeding and defecation patterns of three triatome species (Hemiptera: Reduviidae). Acta Tropica 34, 65–7.Google Scholar
Zeledon, R., Bolanos, R. & Rojas, M. (1984). Scanning electron microscopy of the final phase of the life cycle of Trypanosoma cruzi in the insect vector. Acta Tropica 41, 39–43.Google ScholarPubMed