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Trypanosoma musculi in CBA mice: trypanocidal mechanism eliminating dividing forms

Published online by Cambridge University Press:  06 April 2009

C. Desbiens  and
P. Viens
C. Desbiens
Affiliation:
Department of Microbiology and Immunology, University of Montreal, B.P. 6128, Succ. ‘A’, Montreal P.Q., H3C 3J7
P. Viens
Affiliation:
Department of Microbiology and Immunology, University of Montreal, B.P. 6128, Succ. ‘A’, Montreal P.Q., H3C 3J7
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Summary

Large inocula of dividing form-enriched Trypanosoma musculi parasites, harvested from the peritoneal cavity of infected CBA mice, were given intravenously to mice at various times during the infection. Mice infected for 10 or 15 days (including T cell-deprived, infected mice) eliminated dividing parasites from the blood within a few min, whereas those at earlier stages (1 or 5 days) were less efficient. The initial control of T. musculi parasitaemia thus appears to be due to a trypanocidal mechanism rather than reproduction-inhibiting factor (ablastin).

Type
Research Article
Information
Parasitology , Volume 83 , Issue 1 , August 1981 , pp. 109 - 113
Copyright
Copyright © Cambridge University Press 1981

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References

REFERENCES

Bawden, M. P. (1975). Whence comes Trypanosoma lewisi antigen which induces ablastic antibody: studies in the occult? Experimental Parasitology 38, 350–6.Google Scholar
Clayton, C. E. (1980). A culture system for in vitro studies of immunity to Trypanosoma (Herpetosoma) musculi. Transactions of the Royal Society of Tropical Medicine and Hygiene 74, 125–6.CrossRefGoogle ScholarPubMed
Coventry, F. A. (1930). The trypanosomal action of specific antiserums on Trypanosoma lewisi in vivo. American Journal of Hygiene 12, 366–80.Google Scholar
D'Alesandro, P. A. (1962). In vitro studies of Ablastin, the reproduction-inhibiting antibody to Trypanosoma lewisi. Journal of Protozoology 9, 351–8.Google Scholar
D'Alesandro, P. A. (1966). Immunological and biochemical studies of Ablastin the reproduction-inhibiting antibody to Trypanosoma lewisi. Annals of the New York Academy of Sciences 129, 834–52.CrossRefGoogle Scholar
D'Alesandro, P. A. (1970). Non-pathogenic trypanosomes of rodents. In Immunity to Parasitic Animals, vol. 2 (ed. Jackson, E. J., Herman, R. and Singer, I.) pp. 691–739. New York: Appleton-Century-Crofts.Google Scholar
D'Alesandro, P. A. (1975). Ablastin: the phenomenon. Experimental Parasitology 38, 303–8.Google Scholar
Giannini, H. S. & D'Alesandro, P. A. (1979). Trypanosoma lewisi: accumulation of antigen specific host IgG as a component of the surface coat during the course of infection in the rat. Experimental Parasitology 47, 342–6.CrossRefGoogle ScholarPubMed
Krampitz, H. E. (1969). Verbreitung, Wirt-Parasit-Bezie-hungen und Vermehrung sizilianisher Stamme von Trypanosoma (Herpetosoma) duttoni. Thiroux, 1905 (Protozoa, Trypanosomatidae). Zeitschrift für Parasitenkunde 32, 297–315.Google Scholar
Lajeunesse, M. C., Richards, R., Viens, P. & Targett, G. A. T. (1975). Persistence of dividing forms of Trypanosoma musculi in the peritoneal cavity of infected CBA mice. The International Research Communications System 3, 244.Google Scholar
Lumsden, W. H. R., Herbert, W. J. & McNeillage, G. J. C. (1973). Techniques with Trypanosomes. Edinburgh and London: Churchill Livingstone.Google Scholar
Leuchars, E. (1966). The thymus, irradiation and the immune response. Ph.D. thesis, University of London.Google Scholar
Ormerod, W. E. (1963). The initial stages of infection with Trypanosoma lewisi and their relationship to the formation of antibody. Journal of General Microbiology 21, 387–94.Google Scholar
Patton, C. L. (1975). The ablastin phenomenon: inhibition of membrane function. Experimental Parasitology 38, 357–9.CrossRefGoogle ScholarPubMed
Taliaferro, W. H. (1932). Trypanocidal and reproduction inhibition antibodies to Trypanosoma lewisi in rats and rabbits. American Journal of Hygiene 16, 32–84.Google Scholar
Taliaferro, W. H. & Pizzi, T. (1960). The inhibition of nucleic acid and protein synthesis in Trypanosoma lewisi by the antibody ablastin. Proceedings of the National Academy of Sciences USA, 46, 733–45.CrossRefGoogle ScholarPubMed
Viens, P., Targett, G. A. T., Leuchars, E. & Davies, A. J. S. (1974). The immunological response of CBA mice to Trypanosoma musculi. Initial control of the infection and the effect of T cell deprivation. Clinical and Experimental Immunology 16, 279–94.Google Scholar
Viens, P., Targett, G. A. T., Wilson, V. C. L. C. & Edwards, C. I. (1972). The persistence of Trypanosoma (Herpetosoma) musculi in the kidneys of immune CBA mice. Transactions of the Royal Society of Tropical Medicine and Hygiene 66, 669–70.Google Scholar
Wilson, V. C. L. C., Viens, P., Targett, G. A. T. & Edwards, C. I. (1973). Comparative studies on the persistence of Trypanosoma (Herpetosoma) musculi and T. (H) lewisi in immune hosts. Transactions of the Royal Society of Tropical Medicine and Hygiene 67, 271–2.Google Scholar