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Subversion of immune cell signal transduction pathways by the secreted filarial nematode product, ES-62

Published online by Cambridge University Press:  11 November 2005

W. HARNETT ,
H. S. GOODRIDGE  and
M. M. HARNETT
W. HARNETT
Affiliation:
Department of Immunology, University of Strathclyde, Glasgow G4 0NR, UK
H. S. GOODRIDGE
Affiliation:
Division of Immunology, Infection and Inflammation, University of Glasgow, G11 6NT, UK
M. M. HARNETT
Affiliation:
Division of Immunology, Infection and Inflammation, University of Glasgow, G11 6NT, UK
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Abstract

Filarial nematodes achieve longevity within the infected host by suppressing and modulating the host immune response. To do this, the worms actively secrete products that have been demonstrated to possess immunomodulatory properties. In this article we discuss the immunomodulatory effects of the phosphorylcholine-containing filarial nematode secreted glycoprotein ES-62. In particular we describe how it modulates intracellular signal transduction pathways in a number of different cells of the immune system, in particular B-lymphocytes, T-lymphocytes, macrophages and dendritic cells.

Keywords

ES-62filarial nematodeimmune system cellssignal transduction
Type
Research Article
Information
Parasitology , Volume 130 , Issue S1 , March 2005 , pp. S63 - S68
Copyright
© 2005 Cambridge University Press

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