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A study of the initiation of biliary hyperplasia in rats infected with Fasciola hepatica

Published online by Cambridge University Press:  08 November 2011

John R. Foster
John R. Foster
Affiliation:
Zoology Department, University College, P.O. Box 78, Cardiff
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Summary

Following infection of rats with Fasciola hepatica, an increase in the number of epithelial cells in the common bile duct, labelled with [3H]thymidine, was detected autoradiographically as early as 5 days post-infection (p.i.). This initial mitogenic effect of the infection was limited to that region of the bile duct lying adjacent to the liver, while the region lying next to the duodenum failed to show any increase in labelling until 41 days p.i. Mechanical contact between the parasite and the biliary epithelium did not occur until 41 days p.i. and the initial hyperplasia was evidently not a result of mechanical irritation. The study serves to emphasize the chemical aetiology of the precocious biliary hyperplasia and to more accurately identify its onset.

Type
Research Article
Information
Parasitology , Volume 83 , Issue 2 , October 1981 , pp. 253 - 258
Copyright
Copyright © Cambridge University Press 1981

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References

REFERENCES

Cleaver, J. E. (1967). Thymidine metabolism and cell kinetics. North Holland Research Monographs. Frontiers of Biology, vol. 6. North Holland Publishing Company, Amsterdam.Google Scholar
Dawes, B. (1961). On the early stages of Fasciola hepatica penetrating into the liver of an experimental host, the mouse: a histological picture. Journal of Helminthology Suppl., 41–52.CrossRefGoogle Scholar
Dawes, B. (1963). Hyperplasia of the bile duct in fascioliasis and its relation to the problem of nutrition in the liver fluke, Fasciola hepatica L. Parasitology 53, 123–33.Google Scholar
Dawes, B. & Hughes, D. L. (1964). Fascioliasis: the invasive stages of Fasciola hepatica in mammalian hosts. In Advances in Parasitology, vol. 2 (ed. Dawes, B.). New York and London: Academic Press.Google Scholar
Dawes, B. & Hughes, D. L. (1970). Fascioliasis: the invasive stages in mammals. In Advances in Parasitology, vol. 8 (ed. Dawes, B.). New York and London: Academic Press.Google Scholar
Dow, C., Ross, J. G. & Todd, J. R. (1967). The pathology of experimental fasciolasis in calves. Journal of Comparative Pathology 77, 377–85.CrossRefGoogle Scholar
Foster, J. R. (1979). A study of changes in the structure and chemical composition of host and parasite tissues in Fasciola hepatica infections. Ph.D. thesis, University of Wales.Google Scholar
Girotra, K. L. & Isseroff, H. (1980). Fasciola hepatica: azetidine inhibition of bile duct hyperplasia in the infected rat. Experimental Parasitology 49, 41–6.CrossRefGoogle ScholarPubMed
Isseroff, H., Girard, P. R. & Leve, M. D. (1977). Bile duct enlargement induced in rats after intraperitoneal transplantation. Experimental Parasitology 41, 405–9.CrossRefGoogle ScholarPubMed
Isseroff, H., Sawma, J. T. & Reino, D. (1977). Fascioliasis: role of proline in bile duct hyperplasia. Science 198, 1157–9.CrossRefGoogle ScholarPubMed
Isseroff, H., Tunis, M. & Read, C. P. (1972). Changes in amino acids of bile in Fasciola hepatica infections. Comparative Biochemistry and Physiology 41 B, 157–63.Google ScholarPubMed
Kuralec, B. & Rijavec, M. (1966). Amino acid pool of the liver fluke (Fasciola hepatica L.). Comparative Biochemistry and Physiology 38 A, 525–31.CrossRefGoogle Scholar
Sawma, J. T., Isseroff, H. & Reino, D. (1978). Proline in fascioliasis. IV. Induction of bile duct hyperplasia. Comparative Biochemistry and Physiology 61 A, 239–43.Google Scholar