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Studies of antigens in Plasmodium yoelii

II. Inheritance and recombination of antigenic characters

Published online by Cambridge University Press:  06 April 2009

Lindsey J. Panton ,
G. Knowles  and
D. Walliker
Lindsey J. Panton
Affiliation:
Department of Genetics, University of Edinburgh, West Mains Road, Edinburgh EH9 3JN
G. Knowles
Affiliation:
Department of Genetics, University of Edinburgh, West Mains Road, Edinburgh EH9 3JN
D. Walliker
Affiliation:
Department of Genetics, University of Edinburgh, West Mains Road, Edinburgh EH9 3JN
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Summary

The inheritance of an antigen designated Py-1 in the rodent malaria parasite Plasmodium yoelii has been investigated. A cross was made between 2 lines differing in the electrophoretic mobility and quantity of Py-1 detected by crossed immunoelectrophoresis. In 10 clones isolated from the progeny of the cross the level of Py-1 always correlated with the virulence of the infection and it was concluded that these characters were different phenotypic effects of the same gene mutation. The electrophoretic mobility of Py-1 segregated independently of the virulence character and was therefore controlled by a different gene. These two antigenic markers also recombined with isoenzyme and drug-sensitivity characters distinguishing the parent lines.

Type
Research Article
Information
Parasitology , Volume 89 , Issue 1 , August 1984 , pp. 27 - 34
Copyright
Copyright © Cambridge University Press 1984

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References

Beale, G. H., Carter, R. & Walliker, D. (1978). Genetics. In Rodent Malaria (ed. Killick-Kendrick, R. and Peters, W.), pp. 213–45. London, New York and San Francisco: Academic Press.Google Scholar
Brown, G. V., Coppel, R. L., Vrbova, H., Grumont, R. J. & Anders, R. F. (1982). Plasmodium falciparum: comparative analysis of erythrocyte stage-dependent protein antigens. Experimental Parasitology 53, 279–84.CrossRefGoogle ScholarPubMed
Brown, K. N. & Brown, I. N. (1965). Immunity to malaria: antigenic variation in chronic infections of Plasmodium knowlesi. Nature, London 208, 1286–8.CrossRefGoogle ScholarPubMed
Carter, R. (1978). Studies on enzyme variation in the murine malaria parasites Plasmodium berghei, P. yoelii, P. vinckei and P. chabaudi by starch gel electrophoresis. Parasitology 76, 241–67.CrossRefGoogle ScholarPubMed
Deans, J. A., Dennis, E. D. & Cohen, S. (1978). Antigenic analysis of sequential erythrocytic stages of Plasmodium knowlesi. Parasitology 77, 333–44.CrossRefGoogle ScholarPubMed
Kilejian, A. (1980). Stage-specific proteins and glycoproteins of Plasmodium falciparum: identification of antigens unique to schizonts and merozoites. Proceedings of the National Academy of Sciences USA 77, 3695–9.CrossRefGoogle ScholarPubMed
Knowles, G., Sanderson, A. & Walliker, D. (1981). Plasmodium yoelii: Genetic analysis of crosses between two rodent malaria subspecies. Experimental Parasitology 52, 243–7.CrossRefGoogle ScholarPubMed
Knowles, G. & Walliker, D. (1980). Variable expression of virulence in the rodent malaria parasite Plasmodium yoelii yoelii. Parasitology 81, 211–19.CrossRefGoogle ScholarPubMed
Lumsden, W. H. R., Cunningham, M. P., Webber, W. A. F., van Hoeve, K., Knight, R. H. & Simmons, V. (1965). Some effects of hydrogen ion concentration on trypanosome numbers and infectivity. Experimental Parasitology 16, 8–17.CrossRefGoogle ScholarPubMed
McBride, J. S., Walliker, D. & Morgan, G. (1982). Antigenic diversity in the human malaria parasite Plasmodium falciparum. Science 217, 254–7.CrossRefGoogle ScholarPubMed
Padua, R. A. (1981). Plasmodium chabaudi: Genetics of resistance to chloroquine. Experimental Parasitology 52, 419–26.CrossRefGoogle ScholarPubMed
Panton, L. J., Knowles, G. & Walliker, D. (1984). Studies of antigens in Plasmodium yoelii. I. Antigenic differences between parasite lines detected by crossed immunoelectrophoresis. Parasitology 89, 17–26.CrossRefGoogle ScholarPubMed
Schofield, L., Saul, A., Myler, P. & Kidson, C. (1982). Antigenic differences among isolates of Plasmodium falciparum demonstrated by monoclonal antibodies. Infection and Immunity 38, 893–7.CrossRefGoogle ScholarPubMed
Walliker, D. (1972). An infection of Plasmodium berghei derived from sporozoites of a single oocyst. Transactions of the Royal Society of Tropical Medicine and Hygiene 4, 543.Google Scholar
Walliker, D. (1983). The genetic basis of diversity in malaria parasites. Advances in Parasitology 22, 217–59.CrossRefGoogle ScholarPubMed
Walliker, D., Carter, R. & Morgan, S. (1973). Genetic recombination in Plasmodium berghei. Parasitology 66, 309–20.CrossRefGoogle ScholarPubMed
Walliker, D., Sanderson, A., Yoeli, M. & Hargreaves, B. J. (1976). A genetic investigation of virulence in a rodent malaria parasite. Parasitology 72, 183–94.CrossRefGoogle Scholar
Wilson, R. J. M., McGregor, I. A. & Hall, A. P. (1975). Persistence and recurrence of S-antigens in Plasmodium falciparum infections in man. Transactions of the Royal Society of Tropical Medicine and Hygiene 69, 460–7.CrossRefGoogle ScholarPubMed