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Strain variation in Entamoeba histolytica I. Correlation of invasiveness in rats with the clinical history and treatment of the experimental infections

Published online by Cambridge University Press:  06 April 2009

R. A. Neal  and
Patricia Vincent
R. A. Neal
Affiliation:
The Wellcome Laboratories of Tropical Medicine, London
Patricia Vincent
Affiliation:
The Wellcome Laboratories of Tropical Medicine, London
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Extract

1. Eleven strains of Entamoeba histolytica were isolated from contact carriers and all proved non-invasive to rats.

2. Three strains from cases showing symptoms proved invasive to rats.

3. The treatment of murine infection with non-invasive strains with emetine hydrochloride shows that most of them were successfully cured with six daily oral doses of 2 mg./kg., though one was not susceptible to this dose. Another proved refractory to 4 mg./kg.

4. The results of previous work with kittens are discussed in the light of the present observations.

Type
Research Article
Information
Parasitology , Volume 45 , Issue 1-2 , May 1955 , pp. 152 - 162
Copyright
Copyright © Cambridge University Press 1955

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References

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