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Schistosoma mansoni: development of primary infections in mice genetically deficient or intact in the fifth component of complement

Published online by Cambridge University Press:  06 April 2009

A. Ruppel ,
U. Rother  and
H. J. Diesfeld
A. Ruppel
Affiliation:
Institut für Immunologie und Serologic der Universität Heidelberg, Im Neuenheimer Feld 305, D-6900 Heidelberg, F.R.G.
U. Rother
Affiliation:
Institut für Immunologie und Serologic der Universität Heidelberg, Im Neuenheimer Feld 305, D-6900 Heidelberg, F.R.G.
H. J. Diesfeld
Affiliation:
Institut für Tropenhygiene der Universität Heidelberg, Im Neuenheimer Feld 324, D-6900 Heidelberg, F.R.G.
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Summary

The influence of the late components of complement (C) on percutaneous primary infections with Schistosoma mansoni was studied in inbred mice genetically deficient or intact in C5. Worm recoveries were diminished in C5-deficient male mice as compared to C5-intact animals. Twenty-four-day-old parasites were also shorter following growth in C5-deficient animals. At 7 weeks after infection, female schistosomes, but not male parasites, were shorter and fewer eggs/schistosome pair were deposited in the livers of C5-deficient as compared to C5-intact male mice. In addition to the presence of C5, the mouse sex was found to influence the outcome of an infection. Schistosomes showed a reduced infection rate and were relatively stunted after 24 days of growth in female mice of the two strains as compared to male mice of the corresponding strains. The results suggest that C5 plays no role in defence against a primary infection in mice.

Type
Research Article
Information
Parasitology , Volume 85 , Issue 2 , October 1982 , pp. 315 - 323
Copyright
Copyright © Cambridge University Press 1982

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