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Schistosoma mansoni and S. japonicum: comparison of levels of ultraviolet irradiation for vaccination of mice with cercariae

Published online by Cambridge University Press:  06 April 2009

A. Ruppel ,
Y. E. Shi  and
N. A. Moloney
A. Ruppel
Affiliation:
Institute of Tropical Hygiene, University of Heidelberg, Im Neuenheimer Feld 324, D-6900 Heidelberg, Federal Republic of Germany
Y. E. Shi
Affiliation:
Institute of Parasitology, Tongji Medical University, Wuhan, Hubei-Province, The Peoples Republic of China
N. A. Moloney
Affiliation:
Winches Farm Field Station, London School of Tropical Medicine and Hygiene, St Albans, Herts., UK
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Summary

When cercariae of Schistosoma mansoni and of S. japonicum were irradiated with various levels of u.v. light at 254 nm, their development to perfusable worms was reduced to below 1% at about 200 μW min cm−2. Cercariae attenuated with about 300 μW min cm−2 induced partial resistance against an homologous challenge infection in mice. No differences were observed between the two schistosome species when the same treatment was given to the cercariae. Thus the same u.v. dose can confer immunizing ability to cercariae of both S. mansoni and S. japonicum.

Keywords

cercariaeultraviolet attenuationSchistosomavaccination
Type
Research Article
Information
Parasitology , Volume 101 , Issue 1 , August 1990 , pp. 23 - 26
Copyright
Copyright © Cambridge University Press 1990

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References

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