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Schistosoma japonicum: some parameters affecting the development of protective immunity induced by a cryopreserved, irradiated schistosomula vaccine in guinea-pigs

Published online by Cambridge University Press:  06 April 2009

S. Xu ,
F. Shi  and
H. Wu
S. Xu
Affiliation:
Shanghai Institute of Animal Parasitology, Chinese Academy of Agricultural Sciences, No. 1, Lane 106, Shi-long Road, Shanghai 200030, People's Republic of, China
F. Shi
Affiliation:
Shanghai Institute of Animal Parasitology, Chinese Academy of Agricultural Sciences, No. 1, Lane 106, Shi-long Road, Shanghai 200030, People's Republic of, China
H. Wu
Affiliation:
Shanghai Institute of Animal Parasitology, Chinese Academy of Agricultural Sciences, No. 1, Lane 106, Shi-long Road, Shanghai 200030, People's Republic of, China
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Summary

Experiments were conducted in guinea-pigs to elucidate the parameters affecting the development of protective immunity against Schistosoma japonicum induced by a cryopreserved, irradiated schistosomula vaccine such as the number of immunizations, route of injection and the use of adjuvants. Results obtained indicated that the cryopreserved, irradiated schistosomula vaccine was effective by either intradermal or intramuscular injection. One intradermal injection with BCG adjuvant resulted in an average worm reduction of 50·24%, only a little lower than that of a non-cryopreserved, irradiated vaccine, 53·55%, with no statistically significant difference between the two. By intramuscular injection the worm reduction was lower (max. 40%) whether given with or without adjuvants or in 1 or 2 injections.

Keywords

Schistosoma japonicumguinea-pigscryopreservedirradiated vaccineprotective immunity parameters
Type
Research Article
Information
Parasitology , Volume 102 , Issue 1 , February 1991 , pp. 45 - 47
Copyright
Copyright © Cambridge University Press 1991

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