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Re-feeding rapidly restores protection against Heligmosomoides bakeri (Nematoda) in protein-deficient mice

Published online by Cambridge University Press:  09 February 2007

T. TU ,
K. G. KOSKI ,
L. J. WYKES  and
M. E. SCOTT
T. TU
Affiliation:
School of Dietetics and Human NutritionMcGill University(Macdonald Campus), 21 111 Lakeshore Road, Ste-Anne de Bellevue, Quebec H9X 3V9, Canada
K. G. KOSKI
Affiliation:
School of Dietetics and Human NutritionMcGill University(Macdonald Campus), 21 111 Lakeshore Road, Ste-Anne de Bellevue, Quebec H9X 3V9, Canada
L. J. WYKES
Affiliation:
School of Dietetics and Human NutritionMcGill University(Macdonald Campus), 21 111 Lakeshore Road, Ste-Anne de Bellevue, Quebec H9X 3V9, Canada
M. E. SCOTT*
Affiliation:
Institute of Parasitology, McGill University(Macdonald Campus), 21 111 Lakeshore Road, Ste-Anne de Bellevue, Quebec H9X 3V9, Canada
*
*Corresponding author: Institute of Parasitology, McGill University(Macdonald Campus), 21 111 Lakeshore Road, Ste-Anne de Bellevue, Quebec H9X 3V9, Canada. Tel: +514 398 7996. Fax: +514 398 7857. E-mail: [email protected]
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Summary

This study determined whether the timing of re-feeding of protein-deficient mice restored functional protection against the gastrointestinal nematode, Heligmosomoides bakeri. Balb/c mice were fed a 3% protein-deficient (PD) diet and then transferred to 24% protein-sufficient (PS) diet either on the day of primary infection, 10 days after the primary infection, on the day of challenge infection, or 7 days after the challenge infection. Control mice were fed either the PD or PS diet. Onset of challenge, but not primary, infection caused short-term body weight loss, anorexia and reduced feed efficiency. Weight gain was delayed in mice when re-feeding commenced on the day of challenge infection; alkaline phosphatase (ALP) was also elevated in these mice on day 28 post-challenge. In contrast, other re-feeding groups attained similar body weights to PS mice within 4 days and had similar ALP at day 28. Serum leptin was higher in PD than PS mice and positively associated with food intake. As expected, worm survival was prolonged in mice fed the PD diet. However, egg production and worm burdens were similar in all re-feeding groups to the PS mice, indicating that protein re-feeding during either the primary or challenge infection rapidly restored normal parasite clearance.

Keywords

protein deficiencyprotein re-feedingnutritional statusmousenematodeHeligmosomoides bakeriresistanceinfection-induced weight lossanorexia
Type
Research Article
Information
Parasitology , Volume 134 , Issue 6 , June 2007 , pp. 899 - 909
Copyright
Copyright © Cambridge University Press 2007

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