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Protective heterologous immunity between Plasmodium atheruri and other Plasmodium spp. and Babesia spp. in mice

Published online by Cambridge University Press:  06 April 2009

F. E. G. Cox
F. E. G. Cox
Affiliation:
Department of Zoology, University of London King's College, Strand, London WC2R 2LS.
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Extract

Mice which have recovered from infections with P. atheruri are immune to challenge with the homologous parasite and are also strongly resistant to challenge with P. v. chabaudi and, to a lesser extent, B. rodhaini, B. microti and P. b. yoelii. There is little protection against P. v. vinckei and none against P. b. berghei. In the reciprocal experiments, the greatest degree of protection against P. atheruri occurs after P. v. chahaudi infections but over two-thirds of mice are protected by B. rodhaini or B. microti, half by P. v. vinckei or P. b. berghei but hardly any by P. b. yoelii. The considerable degree of cross-protection which exists between P. atheruri and P. chabaudi can be correlated with some antigenic similarities between these parasites but these are not greater than those of parasites which do not protect against one another.

Type
Research Article
Information
Parasitology , Volume 65 , Issue 3 , December 1972 , pp. 379 - 387
Copyright
Copyright © Cambridge University Press 1972

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References

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