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Protection of mice against Babesia spp. and plasmodium spp. with killed Corynebacterium parvum

Published online by Cambridge University Press:  06 April 2009

I. A. Cleark ,
F. E. G Cox  and
A. C. Allison
I. A. Cleark
Affiliation:
Division of Cell Pathology, Clinical Research Center, Watford Road, Harrow, Middlesex HA1 3UJ and Department of Zoology, University of London, The Strand, London WC2
F. E. G Cox
Affiliation:
Division of Cell Pathology, Clinical Research Center, Watford Road, Harrow, Middlesex HA1 3UJ and Department of Zoology, University of London, The Strand, London WC2
A. C. Allison
Affiliation:
Division of Cell Pathology, Clinical Research Center, Watford Road, Harrow, Middlesex HA1 3UJ and Department of Zoology, University of London, The Strand, London WC2
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Extract

Mice which had been pre-treated with killed Corynebacterium parvum given intravenously or intraperitoneally, but not subcutaneously, were completely resistant ot infection withBabesia microti or B. rodhaini, and protected from death caused by Plasmodium vinckeior P. chabaudiinfection. There is evidence that the parasites died within circulating erythrocytes. This occurred much too soon for a specific antibody response to be evoked, and no antibody could be detected by the indirect fluorescent-anitbody technique. Thus it is suggested that a non-secific soluble mediator may play an important role in the protection observed.

Type
Research Article
Information
Parasitology , Volume 74 , Issue 1 , February 1977 , pp. 9 - 18
Copyright
Copyright © Cambridge University Press 1977

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