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The prevalence and clinical characteristics of tick-borne diseases at One Sentinel Hospital in Northeastern China

Published online by Cambridge University Press:  01 August 2018

Hong-Bo Liu Open the ORCID record for Hong-Bo Liu [Opens in a new window] ,
Ran Wei ,
Xue-Bing Ni ,
Yuan-Chun Zheng ,
Qiu-Bo Huo ,
Bao-Gui Jiang ,
Lan Ma ,
Rui-Ruo Jiang ,
Jin Lv  and
Yun-Xi Liu
...Show all authors
Hong-Bo Liu
Affiliation:
State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, P.R. China
Ran Wei
Affiliation:
The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250014, P.R. China
Xue-Bing Ni
Affiliation:
State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, P.R. China
Yuan-Chun Zheng
Affiliation:
Mudanjiang Forestry Central Hospital, Mudanjiang 157000, P.R. China
Qiu-Bo Huo
Affiliation:
Mudanjiang Forestry Central Hospital, Mudanjiang 157000, P.R. China
Bao-Gui Jiang
Affiliation:
State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, P.R. China
Lan Ma
Affiliation:
State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, P.R. China
Rui-Ruo Jiang
Affiliation:
State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, P.R. China
Jin Lv
Affiliation:
The Second Artillery Corps General Hospital, Beijing 100088, China
Yun-Xi Liu
Affiliation:
Chinese PLA General Hospital, 28 Fu-Xing Road, Hai-Dian District, Beijing 10853, P.R. China
Fang Yang
Affiliation:
Mudangjiang Entry-Exit Inspection and Quarantine Bureau of the People's Republic of China, Mudanjiang 157000, P.R. China
Yun-Huan Zhang
Affiliation:
Mudangjiang Entry-Exit Inspection and Quarantine Bureau of the People's Republic of China, Mudanjiang 157000, P.R. China
Jia-Fu Jiang*
Affiliation:
State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, P.R. China
Na Jia*
Affiliation:
State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, P.R. China
Wu-Chun Cao*
Affiliation:
State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, P.R. China
*
Author for correspondence: Wu-Chun Cao, Na-Jia, and Jia-Fu Jiang, E-mail: [email protected]; [email protected]; [email protected]
Author for correspondence: Wu-Chun Cao, Na-Jia, and Jia-Fu Jiang, E-mail: [email protected]; [email protected]; [email protected]
Author for correspondence: Wu-Chun Cao, Na-Jia, and Jia-Fu Jiang, E-mail: [email protected]; [email protected]; [email protected]
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Abstract

Northeastern China is a region of high tick abundance, multiple tick-borne pathogens and likely human infections. The spectrum of diseases caused by tick-borne pathogens has not been objectively evaluated in this region for clinical management and for comparison with other regions globally where tick-transmitted diseases are common. Based on clinical symptoms, PCR, indirect immunofluorescent assay and (or) blood smear, we identified and described tick-borne diseases from patients with recent tick bite seen at Mudanjiang Forestry Central Hospital. From May 2010 to September 2011, 42% (75/180) of patients were diagnosed with a specific tick-borne disease, including Lyme borreliosis, tick-borne encephalitis, human granulocytic anaplasmosis, human babesiosis and spotted fever group rickettsiosis. When we compared clinical and laboratory features to identify factors that might discriminate tick-transmitted infections from those lacking that evidence, we revealed that erythema migrans and neurological manifestations were statistically significantly differently presented between those with and without documented aetiologies (P < 0.001, P = 0.003). Twelve patients (6.7%, 12/180) were co-infected with two tick-borne pathogens. We demonstrated the poor ability of clinicians to identify the specific tick-borne disease. In addition, it is necessary to develop specific laboratory assays for optimal diagnosis of tick-borne diseases.

Keywords

Chinaco-infectionetiologytick bitetick-borne infectious disease
Type
Research Article
Information
Parasitology , Volume 146 , Issue 2 , February 2019 , pp. 161 - 167
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Copyright
Copyright © Cambridge University Press 2018 

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