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Possible immunological damage to the tegument of Hymenolepis diminuta in mice and rats

Published online by Cambridge University Press:  06 April 2009

A. D. Befus  and
L. T. Threadgold
A. D. Befus
Affiliation:
Wellcome Laboratories for Experimental Parasitology, University of Glasgow, Bearsden, Glasgow, G61 1QH, Scotland
L. T. Threadgold
Affiliation:
Department of Zoology, The Queen's University, Belfast, BT7 1NN, Northern Ireland
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Extract

Opaque or darkened areas (DA) of variable size and position occur on Hymenolepis diminuta in mice and rats. In mice DA normally first appear in the neck region of the worm but subsequently they appear elsewhere and increase in number until destrobilation or worm expulsion. The posterior of destrobilated worms is often darkened. In the more immunogenic infections with six cysticercoids there are more DA per worm than in infections with one cysticercoid. DA are areas of the tegument with a homogeneous increase in electron density; abnormal mitochondria; reduced granular endoplasmic reticulum, Golgi complexes and discoidal secretory bodies; and accumulation of lipid droplets. DA disappear from worms maintained for up to 4 h in Hanks' balanced salt solution and can be induced by mechanical damage to the worms.

As the numbers of DA increase with the duration and intensity of infection and have similarities with types of cell injury, they are probably sites of worm pathology induced by host immunity.

Type
Research Article
Information
Parasitology , Volume 71 , Issue 3 , December 1975 , pp. 525 - 534
Copyright
Copyright © Cambridge University Press 1975

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References

Abraham, E. P. & Robb-Smith, A. H. T. (1970). Degenerative changes and some of their consequences. In General Pathology, 4th edn. (ed. Florey, H. W.), pp. 413–30. London: Lloyd-Luke Ltd.Google Scholar
Andreassen, J., Hindsbo, O. & Hesselberg, C. A. (1974). Immunity to Hymenolepis diminuta in rats: destrobilation and expulsion in primary infections, its suppression by cortisone treatment and increased resistance to secondary infections. Proceedings, Third International Congress of Parasitology2, 1056–7.Google Scholar
Befus, A. D. (1974). The immunoglobulin coat on Hymenolepis spp. Transactions of the Royal Society of Tropical Medicine and Hygiene 68, 273.Google ScholarPubMed
Befus, A. D. (1975). Secondary infections ofHymenolepis diminuta in mice: effects of varying worm burdens in primary and secondary infections. Parasitology 71, 61–75.CrossRefGoogle ScholarPubMed
Befus, A. D. & Featherston, D. W. (1974). Delayed rejection of single Hymenolepis diminuta in primary infections of young mice. Parasitology 69, 77–85.CrossRefGoogle ScholarPubMed
Churg, J. & Grishman, E. (1972). Ultrastructure of immune deposits in renal glomeruli. Annals of Medicine 76, 479–86.Google ScholarPubMed
Cochrane, C. G. & Koffler, D. (1973). Immune complex disease in experimental animals and man. In Advances in Immunology (ed. Dixon, F. J. and Kunkel, H. G.), vol. 16, pp. 185–264. New York, London: Academic Press.Google Scholar
Dixon, K. C. (1970). Disorders of the cell. In Companion to Medical Studies (ed. Passmore, R. and Robson, J. S.), vol. 2, pp. 25.1–25.44. Oxford, Edinburgh: Blackwell Scientific Publications Ltd.Google Scholar
Edwards, A. J., Burt, J. S. & Ogilvie, B. M. (1971). The effect of immunity upon some enzymes of the parasitic nematode Nippostrongylus brasiliensis. Parasitology 62, 339–47.CrossRefGoogle ScholarPubMed
Evans, W. S. (1973). The in vitro cultivation of Hymenolepsis nana and H. microstoma. Ph.D. thesis, University of Glasgow, Scotland.Google Scholar
Ford, B. R. (1972). Hymenolepis citelli: development and chemical composition in hypothermic ground squirrels. Experimental Parasitology 32, 62–70.CrossRefGoogle ScholarPubMed
Gray, J. S. (1973). Studies on host resistance to secondary infections of Raillietina cesticillus Molin, 1858 in the fowl. Parasitology 67, 375–82.CrossRefGoogle ScholarPubMed
Harness, E., Smith, K. & Bland, P. (1973). Structural changes in the bovine nematode Haemonchus placei, that may be associated with host immune responses. Parasitology 66, 199–205.CrossRefGoogle Scholar
Henney, R. W., MacLean, J. M. & Mulligan, W. (1971). The effect of host immunity on the metabolism of Nippostrongylus brasiliensis. Immunology 21, 711–8.Google Scholar
Hockley, D. J. (1973). Ultrastructure of the tegument of Schistosoma. In Advances in Parasitology (ed. Dawes, B.), vol. 11, pp. 233–305. London, New York: Academic Press.Google Scholar
Hockley, D. J. & Smithers, S. R. (1970). Damage to adult Schistosomamansoni after transfer to a hyperimmune host. Parasitology 61, 95–100.CrossRefGoogle Scholar
Hopkins, C. A. & Stallard, H. E. (1974). Immunity to intestinal tapeworms: the rejection of Hymenolepis citelli by mice. Parasitology 69, 63–76.CrossRefGoogle ScholarPubMed
Hopkins, C. A. & Stallard, H. E. (1975). The effect of cortisone on the survival of Hymenolepis diminuta in mice. (Submitted for publication.)Google Scholar
Hopkins, C. A., Grant, P. M. & Stallard, H. (1973). The effect of oxyclozanide on Hymenolepis microstoma and H. diminuta. Parasitology 66, 355–65.CrossRefGoogle ScholarPubMed
Hopkins, C. A., Subramanian, G. & Stallard, H. (1972 a). The development of Hymenolepis diminuta in primary and secondary infections of mice. Parasitology 64, 401–12.CrossRefGoogle Scholar
Hopkins, C. A., Subramanian, G. & Stallard, H. (1972 b). The effect of immunosuppressants on the development of Hymenolepis diminuta in mice. Parasitology 65, 111–20.CrossRefGoogle ScholarPubMed
Lee, D. L. (1969). Changes in adult Nippostrongylus brasiliensis during the development of immunity to this nematode in rats. 1. Changes in ultrastructure. Parasitology 59, 29–39.CrossRefGoogle ScholarPubMed
Lee, D. L. (1971). Changes in adult Nippostrongylus brasiliensis during the development of immunity to this nematode in rats. 2. Total lipids and neutral lipids. Parasitology 63, 271–4.CrossRefGoogle ScholarPubMed
Lumsden, R. D. (1975). Surface ultrastructure and cytochemistry of parasitic helminths. Experimental Parasitology 37, 267–339.CrossRefGoogle ScholarPubMed
Ogilvie, B. M. & Hockley, D. J. (1968). Effects of immunity on Nippostrongylus brasiliensis adult worms: reversible and irreversible changes in infectivity, reproduction, and morphology. The Journal of Parasitology 54, 1073–84.CrossRefGoogle ScholarPubMed
Ogilvie, B. M. & Jones, V. E. (1973). Immunity in the parasitic relationship between helminths and hosts. In Progress in Allergy (ed. Kallos, P., Waksman, B. H. and de Weck, A.), vol. 17, pp. 93–144. Basel, München, Paris, London, New York, Sydney: S. Karger.Google Scholar
Perez, H. & Terry, R. J. (1973). The killing of adult Schistosoma mansoni in vitro in the presence of antisera to host antigenic determinants and peritoneal cells. International Journal for Parasitology 3, 499–503.CrossRefGoogle ScholarPubMed
Peters, D. K. (1974). The immunological basis of glomerulonephritis. Proceedings of the Royal Society of Medicine 67, 557–62.CrossRefGoogle ScholarPubMed
Podesta, R. B. & Mettrick, D. F. (1974). Pathophysiology of cestode infections: effect of Hymenolepis diminuta on oxygen tensions, pH and gastrointestinal function. International Journal for Parasitology 4, 277–92.CrossRefGoogle ScholarPubMed
Reid, W. M. (1942). Certain nutritional requirements of the fowl cestode Raillietina cesticillus (Molin) as demonstrated by short periods of starvation of the host. The Journal of Parasitology 28, 319–40.CrossRefGoogle Scholar
Remington, R. D. & Schork, M. A. (1970). Statistics with Applications to the Biological and Health Sciences. New Jersey: Prentice-Hill, Inc.Google Scholar
Sanderson, B. E., Jenkins, D. C. & Phillipson, R. F. (1972). Nippostrongylus brasiliensis: relation between immune damage and acetylcholinesterase levels. International Journal for Parasitology 2, 227–32.CrossRefGoogle ScholarPubMed
Threadgold, L. T. & Read, C. P. (1970). Hymenolepis diminuta: ultrastructure of a unique membrane specialisation in tegument. Experimental Parasitology 28, 246–52.CrossRefGoogle ScholarPubMed
Trump, B. J. & Arstila, A. U. (1971). Cell injury and cell death. In Principles of Patho-biology (ed. La Via, M. F. and Hill, R. B. Jr.,) pp. 9–95. New York, London, Toronto: Oxford University Press.Google Scholar
Turton, J. A. (1968). The growth and development of Hymenolepis diminuta and H. nana in vitro and in vivo. Ph.D. thesis, University of Glasgow, Scotland.Google Scholar
Walley, J. K. (1966). Oxyclozanide (3, 3′, 5, 5′, 6-pentachloro-2, 2′-dihydroxy-benzanilide-‘Zanil’) in the treatment of the liver fluke Fasciola hepatica in sheep and cattle. The Veterinary Record 78, 267–76.CrossRefGoogle ScholarPubMed
Weinmann, C. J. (1966). Immunity mechanisms in cestode infections. In Biology of Parasites (ed. Soulsby, E. J. L.), pp. 301–20. New York, London: Academic Press.Google Scholar