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Population genetics of concurrent selection with albendazole and ivermectin or diethylcarbamazine on the possible spread of albendazole resistance in Wuchereria bancrofti

Published online by Cambridge University Press:  12 July 2006

A. E. SCHWAB ,
T. S. CHURCHER ,
A. J. SCHWAB ,
M.-G. BASÁÑEZ  and
R. K. PRICHARD
A. E. SCHWAB
Affiliation:
Institute of Parasitology, McGill University, 21111 Lakeshore Road, Ste-Anne-de-Bellevue, Quebec, Canada, H9X 3V9
T. S. CHURCHER
Affiliation:
Department of Infectious Disease Epidemiology, St Mary's Campus, Imperial College London, Norfolk Place, London W2 1PG, UK
A. J. SCHWAB
Affiliation:
Research Institute of the McGill University, Health Centre General Hospital, 1650 Cedar Avenue, Montreal, Quebec, Canada, H3G 1A4
M.-G. BASÁÑEZ
Affiliation:
Department of Infectious Disease Epidemiology, St Mary's Campus, Imperial College London, Norfolk Place, London W2 1PG, UK
R. K. PRICHARD
Affiliation:
Institute of Parasitology, McGill University, 21111 Lakeshore Road, Ste-Anne-de-Bellevue, Quebec, Canada, H9X 3V9
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Abstract

The Global Program for the Elimination of Lymphatic Filariasis (GPELF) intends to achieve its aims through yearly mass treatments with albendazole (ABZ) combined with ivermectin (IVM) or diethylcarbamazine (DEC). The use of ABZ and IVM separately to combat parasites of veterinary importance has, on many occasions, resulted in widespread drug resistance. In order to help predict the spread of potential ABZ resistance alleles through a population of Wuchereria bancrofti, we have developed a mathematical model that incorporates population genetics into EPIFIL, a model which examines the transmission dynamics of the parasite. Our model considers the effect of the combined treatments on the frequency of a recessive allele, which confers ABZ resistance. The model predicts that after 10 yearly treatments with ALB and DEC, 85% coverage and an initial resistance allele frequency of 5%, the frequency of the resistance genotype will increase from 0·25 to 12·7%. If non-random mating is assumed, the initial genotype frequency will be 2·34% and will increase to 62·7%. ABZ and IVM combination treatment may lead to weaker selection for this genotype. Treatment coverage, initial allele frequencies and number of treatments also affect the rate of selection.

Keywords

Wuchereria bancroftidrug resistancemathematical modelpopulation geneticsalbendazole
Type
Research Article
Information
Parasitology , Volume 133 , Issue 5 , November 2006 , pp. 589 - 601
Copyright
2006 Cambridge University Press

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