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Plasmodium chabaudi chabaudi chronic malaria and pathologies of the urogenital tract in male and female BALB/c mice

Published online by Cambridge University Press:  01 March 2004

M. BARTHÉLÉMY ,
P. N. VUONG ,
C. GABRION  and
G. PETIT
M. BARTHÉLÉMY
Affiliation:
Laboratoire de Parasitologie Evolutive CNRS UMR 7103, Cc 175, Université Pierre et Marie Curie, 9 quai Saint-Bernard, 75252 Paris Cedex 05, France
P. N. VUONG
Affiliation:
Unité d'Anatomie et de Cytologie Pathologiques, Hôpital Saint-Michel, 33 rue Olivier de Serres, 75015 Paris, France
C. GABRION
Affiliation:
Laboratoire de Parasitologie Evolutive CNRS UMR 7103, Cc 175, Université Pierre et Marie Curie, 9 quai Saint-Bernard, 75252 Paris Cedex 05, France
G. PETIT
Affiliation:
Laboratoire de Parasitologie Evolutive CNRS UMR 7103, Cc 175, Université Pierre et Marie Curie, 9 quai Saint-Bernard, 75252 Paris Cedex 05, France
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Abstract

BALB/c mice of both sexes were infected with a non-virulent strain of Plasmodium chabaudi chabaudi and any pathologies occurring in the urogenital tract and its accessory glands were investigated. Organs and tracts were removed from infected and control mice at 15, 40 and 100 days post-injection, weighed and processed for macroscopical and histological analyses. The relative weights of preputial, clitoral glands and testes were modified in infected mice during the 40 days following infection. The preputial glands show a marked hypotrophy at 15 days post-infection. The bladders of half of the infected female mice and a few infected male mice displayed a conspicuous haemoglobinuria and frequent interstitial cystitis that worsened throughout the experiment. Also, several chronic inflammatory reactions were detected in the prostates, preputial and clitoral glands up to 100 days post-infection. A probable cause of such a divergence in the characteristics of the infection and in the nature of the pathologies identified in infected male and female mice is the interaction between the infection and the immune and endocrine systems of the host. The cause of the pathologies and their consequences on the host condition are discussed.

Keywords

chronic malariaBALB/c miceurogenital tractpathologyhistologyPlasmodium chabaudi chabaudi
Type
Research Article
Information
Parasitology , Volume 128 , Issue 2 , February 2004 , pp. 113 - 122
Copyright
2004 Cambridge University Press

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