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Parasite-induced learned taste aversion involving Nippostrongylus in rats

Published online by Cambridge University Press:  06 April 2009

Anne Keymer ,
D. W. T. Crompton  and
B. J. Sahakian
Anne Keymer
Affiliation:
Department of Parasitology, The Molteno Institute, University of Cambridge, Downing Street, CambridgeCB2 3EE
D. W. T. Crompton
Affiliation:
Department of Parasitology, The Molteno Institute, University of Cambridge, Downing Street, CambridgeCB2 3EE
B. J. Sahakian
Affiliation:
Dunn Clinical Nutrition Centre, University of Cambridgeand M.R.C. Dunn Nutritional Unit, Addenbrooke's Hospital, Trumpington Street, CambridgeCB2 1QE
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Summary

After demonstrating that rats were capable of discriminating between the same diet treated with either flavour 1 or flavour 2 and that the 2 flavours of diet were equipreferred, an experiment was carried out to see whether learned taste aversion might play a role in the reduction of food intake that is commonly observed during the course of a parasitic infection. The results showed that rats, given a subcutaneous inoculation of approximately 6000 third-stage larvae of Nippostrongylus brasiliensis (Nematoda) while feeding on a diet containing flavour 2, strongly preferred to eat diet containing flavour 1 when given simultaneous choice conditions. Uninfected rats showed no preference and ate equal amounts of both flavoured diets. This effect is interpreted as the first experimental demonstration of learned taste aversion using a eukaryotic parasite as the inductive agent.

Type
Research Article
Information
Parasitology , Volume 86 , Issue 3 , June 1983 , pp. 455 - 460
Copyright
Copyright © Cambridge University Press 1983

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References

REFERENCES

Anderson, N., Blake, R. & Titchen, D. A. (1976). Effects of a series of infections of Ostertagia circumcincta on gastric secretion of sheep. Parasitology 72, 1–12.CrossRefGoogle ScholarPubMed
Bueno, L., Ruckebusch, Y. & Durchies, P. (1979). Disturbances of digestive motility in horses associated with strongyle infections. Veterinary Parasitology 5, 253–60.CrossRefGoogle Scholar
Bueno, L., Dakkak, A. & Fioramonti, J. (1982). Gastro-duodenal motor activity and transit disturbances associated with Haemonchus contortus infection in sheep. Parasitology 84, 367–74.CrossRefGoogle Scholar
Crompton, D. W. T. (1983). The influence of parasitic infection on food intake. Federation Proceedings (in the Press).Google Scholar
Crompton, D. W. T., Arnold, S., Coward, W. A. & Lunn, P. G. (1978). Nippostrongylus (Nematoda) infection in protein-malnourished rats. Transactions of the Royal Society of Tropical Medicine and Hygiene 72, 195–7.CrossRefGoogle ScholarPubMed
Crompton, D. W. T. & Nesheim, M. C. (1976). Host-parasite relationships in the alimentary tract of domestic birds. Advances in Parasitology 14, 94–194.Google ScholarPubMed
Crompton, D. W. T., Walters, D. E. & Arnold, S. (1981). Changes in the food in take and body weight of protein-malnourished rats infected with Nippostrongylus brasiliensis (Nematoda). Parasitology 82, 23–38.CrossRefGoogle Scholar
Gustavson, C. R. (1977). Comparative and field aspects of learned food aversion. In Learning Mechanisms in Food Selection (ed. Barker, L. M., Best, M. R. and Domjam, M.), pp. 23–43. Texas: Baylor University Press.Google Scholar
Keymer, A. E., Crompton, D. W. T. & Walters, D. E. (1983). Nippostrongylus (Nematoda) in protein-malnourished rats: host mortality, morbidity and rehabilitation. Parasitology 86, 461–75.CrossRefGoogle ScholarPubMed
Nesheim, M. C., Crompton, D. W. T., Arnold, S. & Barnard, D. (1977). Dietary relations between Moniliformis (Acanthocephala) and laboratory rats. Proceedings of the Royal Society of London, B 197, 363–83.Google ScholarPubMed
Orkaca-Tetteh, R.(1964). Protein values of Ghanaian diets and the effect on protein metabolism of infestation of the rat with Nippostrongylus muris. Ph.D. thesis, University of London.Google Scholar
Sykes, A. R. & Coop, R. L. (1977). Chronic parasitism and animal efficiency. Agricultural Research Council Research Review 3, 41–6.Google Scholar
Symons, L. E. A. (1969). Pathology of gastrointestinal helminthiases. In International Review of Tropical Medicine vol. 3, (ed. Lincicome, D. R. and Woodruff, A. W.), pp. 49–100. New York and London: Academic Press.Google Scholar
Symons, L. E. A. (1976). Malabsorption. In Pathophysiology of Parastic Infection,(ed. Soulsby, E. J. L.), pp. 11–21. New York, San Francisco and London: Academic Press.Google Scholar
Symons, L. E. A. & Hennessy, D. R. (1981). Cholecystokinin and anorexia in sheep infected by the intestinal nematode Trichostrongylus colubriformis. International Journal for Parasitology 11, 55–8.CrossRefGoogle ScholarPubMed
Tomkins, A. M. (1979). The role of intestinal parasites in diarrhoea and malnutrition. Tropical Doctor 9, 21–4.CrossRefGoogle ScholarPubMed