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The occurrence and significance of triploidy in the liver fluke, Fasciola hepatica

Published online by Cambridge University Press:  19 January 2004

H. L. FLETCHER ,
E. M. HOEY ,
N. ORR ,
A. TRUDGETT ,
I. FAIRWEATHER  and
M. W. ROBINSON
H. L. FLETCHER
Affiliation:
Parasite Proteomics and Therapeutics Research Group, The Queen's University of Belfast, School of Biology and Biochemistry, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK
E. M. HOEY
Affiliation:
Parasite Proteomics and Therapeutics Research Group, The Queen's University of Belfast, School of Biology and Biochemistry, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK
N. ORR
Affiliation:
Parasite Proteomics and Therapeutics Research Group, The Queen's University of Belfast, School of Biology and Biochemistry, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK Present address: Department of Haematology, ‘C’ Floor, Belfast City Hospital, 51 Lisburn Road, Belfast BT9 7AB.
A. TRUDGETT
Affiliation:
Parasite Proteomics and Therapeutics Research Group, The Queen's University of Belfast, School of Biology and Biochemistry, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK
I. FAIRWEATHER
Affiliation:
Parasite Proteomics and Therapeutics Research Group, The Queen's University of Belfast, School of Biology and Biochemistry, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK
M. W. ROBINSON
Affiliation:
Parasite Proteomics and Therapeutics Research Group, The Queen's University of Belfast, School of Biology and Biochemistry, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK Present address: The Queen's University of Belfast, The Dept. of Veterinary Science, Stoney Road, Stormont, Belfast BT4 3SD.
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Abstract

Karyotyping of Fasciola hepatica samples from Britain and Ireland has identified a triploid isolate which is effectively aspermic, rendering it necessarily asexually reproducing. Considering the extensive presence of asexually reproducing diploid and triploid Fasciola in Asia it is suggested that facultative gynogenesis is widespread in this parasite. This has important implications for the population genetics and evolution of Fasciola, especially in relation to the development and spread of drug resistance, and must be considered in the mathematical modelling of this process.

Keywords

Fasciola hepaticatriploidykaryotypeparthenogenesisdrug resistance
Type
Research Article
Information
Parasitology , Volume 128 , Issue 1 , January 2004 , pp. 69 - 72
Copyright
2004 Cambridge University Press

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References

REFERENCES

AGATSUMA, T., TERASAKI, L., YANG, L. & BLAIR, D. (1994). Genetic variation in the triploids of Japanese Fasciola species, and relationships with other species in the genus. Journal of Helminthology 68, 181–186.CrossRefGoogle Scholar
ANDREWS, S. J. (1999). The life cycle of Fasciola hepatica. In Fasciolosis (ed. Dalton, J. P.), pp. 1–29. CABI, Oxon.
BENAZZI LENTATI, G. (1966). Amphimixis and pseudogamy in freshwater triclads: experimental reconstitution of polyploid pseudogamic biotypes. Chromosoma (Berl.) 20, 1–14.Google Scholar
BENAZZI LENTATI, G. (1970). Gametogenesis and egg fertilization in planarians. International Review of Cytology 27, 101–179.CrossRefGoogle Scholar
ITAGAKI, T., TSUTSUMI, K., ITO, K. & TSUTSUMI, Y. (1998). Taxonomic status of the Japanese Triploid forms of Fasciola: Comparison of mitochondrial ND1 and COI sequences with F. hepatica and F. gigantica. Journal of Parasitology 84, 445–448.CrossRefGoogle Scholar
KWA, M. S., KOOYMAN, F. N., BOERSEMA, J. H. & ROOS, M. H. (1993). Effect of selection for benzimidazole resistance in Haemonchus contortus on beta-tubulin isotype 1 and isotype 2 genes. Biochemical and Biophysical Research Communications 191, 413–419.CrossRefGoogle Scholar
LAGRANGE, E. & GUTMANN, A. (1961). Sur l'infestation experimentale de la souris par Fasciola hepatica. Rivista di Parassitologia 22, 93–101.Google Scholar
MAYNARD-SMITH, J. (1976). Evolution of Sex. Cambridge University Press, Cambridge.
MOLL, L., GAASENBEEK, C. P. H., VELLEMA, P. & BORGSTEEDE, F. H. M. (2000). Resistance of Fasciola hepatica against triclabendazole in cattle and sheep in the Netherlands. Veterinary Parasitology 91, 153–158.CrossRefGoogle Scholar
MORIYAMA, N., TSUJI, M. & SETO, T. (1979). Three karyotypes and their phenotypes of Japanese liver flukes (Fasciola sp). Japanese Journal of Parasitology 28, 23–33.Google Scholar
MULLER, H. J. (1932). Some genetic aspects of sex. American Naturalist 66, 118–138.CrossRefGoogle Scholar
OVEREND, D. J. & BOWEN, F. L. (1995). Resistance of Fasciola hepatica to triclabendazole. Australian Veterinary Journal 72, 275–276.CrossRefGoogle Scholar
RHEE, J. K., EUN, G. S. & LEE, S. B. (1987). Karyotype of Fasciola sp. obtained from Korean cattle. The Korean Journal of Parasitology 25, 37–44.Google Scholar
SAKAGUCHI, Y. (1980). Karyotype and gametogenesis of the common liver fluke, Fasciola sp., in Japan. Japanese Journal of Parasitology 29, 507–513.Google Scholar
SANDERSON, A. R. (1958). Maturation and fertilization in two digenetic trematodes, Haplometra cylindracea (Zeder 1800) and Fasciola hepatica (L.). Proceedings of the Royal Society Edinburgh 67, 1958–1959.Google Scholar
TERASAKI, K., AKAHANE, H., HABE, S. & MORIYAMA, N. (1982). The geographical distribution of common liver flukes (the genus Fasciola) with normal and abnormal spermatogenesis. Japanese Journal of Veterinary Science 44, 223–231.CrossRefGoogle Scholar
TERASAKI, K., NODA, Y., SHIBAHARA, T. & ITAGAKI, T. (2000). Morphological comparisons and hypotheses on the origin of polyploids in parthenogenetic Fasciola sp. Journal of Parasitology 86, 724–729.Google Scholar
TERASAKI, K., ITAGAKI, T., SHIBAHARA, T., NODA, Y. & MORIYAMA-GONDA, N. (2001). Comparative study of the reproductive organs of Fasciola groups by optical microscope. Journal of Veterinary Medical Science 63, 735–742.CrossRefGoogle Scholar