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Nippostrongylus brasiliensis: observations on factors affecting the establishment of secondary worm populations in rats

Published online by Cambridge University Press:  06 April 2009

D. Conwil Jenkins
D. Conwil Jenkins
Affiliation:
The Research Laboratories, May and Baker Ltd., Dagenham, Essex
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Extract

Previously immunized rats of different ages were exposed either to one large, or several small challenge infections with the nematode, Nippostrongylus brasiliensis. The number of secondary worms harboured by each of these rats was then determined on the fourteenth day after exposure to challenge. It was found that worms adapted more efficiently to host immunity when both (a) the rats were less than 11 weeks old when challenged and (b) the challenge was given in small repeated doses over a period of weeks. The age of the rats on exposure to the immunizing primary infection, however, had little or no affect per se on the subsequent establishment of immune-adapted worms. It is tentatively suggested that the failure of worms to adapt effectively to the acquired immunity of older rats resulted from the acquisition by these rats of a fully competent cellular immune response.

Type
Research Article
Information
Parasitology , Volume 68 , Issue 1 , February 1974 , pp. 13 - 17
Copyright
Copyright © Cambridge University Press 1974

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