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Nippostrongylus brasiliensis infections in mice: the immunological basis of worm expulsion

Published online by Cambridge University Press:  06 April 2009

R. J. Love
R. J. Love
Affiliation:
Division of Parasitology, National Institute for Medical Research, London NW7 1AA
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Extract

Nippostrongylus brasiliensis infections in mice were terminated more rapidly than in rats and immunologically induced damage occurred earlier. Like rats, mice expelled damaged worms more rapidly than normal worms. Recipients of cells from the spleen or mesenteric node of immune mice expelled their worms by day 8 of the infection. Recipients of cells alone or antiserum alone did not expel their worms by day 5 but mice given both cells and antiserum expelled their worms by this stage of the infection. Damaged worms were expelled more rapidly than normal worms from mice given immune cells. This work indicates that antibodies and cells collaborate to expel N. brasiliensis from mice as has been shown to occur in rats.

Type
Research Article
Information
Parasitology , Volume 70 , Issue 1 , February 1975 , pp. 11 - 18
Copyright
Copyright © Cambridge University Press 1975

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References

Jarrett, E. E. E., Jarrett, W. F. H., & Urquhart, G. M., (1968). Quantitative studies on the kinetics of establishment and expulsion of intestinal nematode populations in susceptible and immune hosts. Nippostrongylus brasiliensis in the rat. Parasitology 58, 625–40.CrossRefGoogle ScholarPubMed
Love, R. J., (1974). Nippostrongylus brasiliensis in rats: both antibodies and cells are necessary for the immunological control of developing larvae. International Archives of Allergy (In press.)Google Scholar
Love, R. J., & Ogilvie, B. M., (1974). Nippostrongylus brasiliensis in young rats: failure to induce expulsion of adult worm populations by lymphoid cells. (In preparation.)Google Scholar
Ogilvie, B. M., (1971). Nippostrongylus brasiliensis in mice: an explanation for the failure to induce worm expulsion from passively immunised animals. International Journal for Parasitology 1, 161–7.Google Scholar
Ogilvie, B. M., & Hockley, D. J., (1968). Effects of immunity on Nippostrongylus brasiliensis adult worms: reversible and irreversible changes in infectivity, reproduction and morphology. Journal of Parasitology 54, 1073–84.Google Scholar
Ogilvie, B. M., & Love, R. J., (1974). Cooperation between antibodies and cells in immunity to a nematode parasite. Transplantation Reviews 19, 147–68.Google ScholarPubMed
Solomon, M. S., & Haley, A. J., (1966). Biology of the rat nematode, Nippostrongylus brasiliensis (Travassos, 1914). V. Characteristics of N. brasiliensis after serial passage in the laboratory mouse. Journal of Parasitology 52, 237–41.Google Scholar