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Molecular mechanisms of sequestration in malaria

Published online by Cambridge University Press:  06 April 2009

A. R. Berendt ,
D. J. P. Ferguson ,
J. Gardner ,
G. Turner ,
A. Rowe ,
C. McCormick ,
D. Roberts ,
A. Craig ,
R. Pinches  and
B. C. Elford
...Show all authors
A. R. Berendt
Affiliation:
Molecular Parasitology Group, Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK
D. J. P. Ferguson
Affiliation:
Molecular Parasitology Group, Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK
J. Gardner
Affiliation:
Molecular Parasitology Group, Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK
G. Turner
Affiliation:
Molecular Parasitology Group, Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK
A. Rowe
Affiliation:
Molecular Parasitology Group, Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK
C. McCormick
Affiliation:
Molecular Parasitology Group, Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK
D. Roberts
Affiliation:
Molecular Parasitology Group, Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK
A. Craig
Affiliation:
Molecular Parasitology Group, Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK
R. Pinches
Affiliation:
Molecular Parasitology Group, Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK
B. C. Elford
Affiliation:
Molecular Parasitology Group, Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK
C. I. Newbold
Affiliation:
Molecular Parasitology Group, Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK
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Extract

Cell surface molecules have received intense attention in recent years because of the central roles they play at the interface between the external environment and the cellular interior. Their functions include adhesion to other cells or extracellular matrices, protection against hostile physical, chemical and biological agents and the transport of metabolites into and out of the cell. In addition, cell surface molecules transduce signals across the cell membrane, relaying information inwards and presenting altered characteristics to the exterior as the environment changes.

Keywords

malariaplasmodiumcytoadherencesequestrationpathogenesisantigenic variationcell surfaceerythrocyte.
Type
Research Article
Information
Parasitology , Volume 108 , supplement S1: Symposia of the British Society for Parasitology Volume 31:Functional molecules on the surface of protozoan parasites , March 1994 , pp. S19 - S28
Copyright
Copyright © Cambridge University Press 1994

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