Hostname: page-component-586b7cd67f-vdxz6 Total loading time: 0 Render date: 2024-11-26T12:10:01.663Z Has data issue: false hasContentIssue false
  • English
  • Français

Metastasis of Theileria annulata macroschizont-infected cells in scid mice is mediated by matrix metalloproteinases

Published online by Cambridge University Press:  01 March 1998

R. P. T. SOMERVILLE ,
R. E. ADAMSON ,
C. G. D. BROWN  and
F. R. HALL
R. P. T. SOMERVILLE
Affiliation:
Department of Biology, PO Box 373, University of York, York YO1, 5YW UK Present address: Department of Neurosciences, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA.
R. E. ADAMSON
Affiliation:
Department of Biology, PO Box 373, University of York, York YO1, 5YW UK
C. G. D. BROWN
Affiliation:
Centre for Tropical Veterinary Medicine, University of Edinburgh, Easter Bush, Roslin, Edinburgh EH25 9RG, Scotland, UK
F. R. HALL
Affiliation:
Department of Biology, PO Box 373, University of York, York YO1, 5YW UK
Get access Rights & Permissions [Opens in a new window]

Abstract

Theileria annulata (Ta)-infected leucocytes are able to disseminate in scid mice. The dose of virulent parasites of the Ta-Ode line required to achieve quantifiable dissemination was found to be 2×10 cells given i.p. Dissemination was higher on day 11 post-inoculation than on day 18. The attenuated Ta-Ode cells were found to disseminate very poorly compared to their virulent progenitors, which correlates with a marked reduction in matrix metalloproteinase (MMP) expression. A daily i.p. injection of mice with BB94, a synthetic inhibitor of MMPs, almost completely ablated dissemination compared to controls. This provides strong evidence that metastasis of Theileria annulata macroschizont-infected host cells is mediated by host MMPs induced by the parasite. This has important implications for explaining a number of pathological features of tropical theileriosis in cattle.

Keywords

Theiliera annulatamacroschizont-infected cellsscid micemetastasismatrix metalloproteinaseBB94attenuation
Type
Research Article
Information
Parasitology , Volume 116 , Issue 3 , March 1998 , pp. 223 - 228
Copyright
1998 Cambridge University Press

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)