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Metabolomic systems biology of trypanosomes

Published online by Cambridge University Press:  17 February 2010

MICHAEL P. BARRETT ,
BARBARA M. BAKKER  and
RAINER BREITLING
MICHAEL P. BARRETT*
Affiliation:
Faculty of Biomedical and Life Sciences and Wellcome Trust Centre of Molecular Parasitology, University of Glasgow, Glasgow Biomedical Research Centre, Glasgow G12 8TA, United Kingdom
BARBARA M. BAKKER
Affiliation:
Department of Pediatrics, Center for Liver, Digestive and Metabolic Diseases, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
RAINER BREITLING
Affiliation:
Groningen Bioinformatics Centre, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Kerklaan 30, 9751 NN Haren, The Netherlands
*
*Corresponding author: Faculty of Biomedical and Life Sciences and Wellcome Trust Centre of Molecular Parasitology, University of Glasgow, Glasgow Biomedical Research Centre, Glasgow G12 8TA, United Kingdom. Tel: 0141-330-6904. Fax: 0141-330-4600. Email: [email protected]
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Summary

Metabolomics analysis, which aims at the systematic identification and quantification of all metabolites in biological systems, is emerging as a powerful new tool to identify biomarkers of disease, report on cellular responses to environmental perturbation, and to identify the targets of drugs. Here we discuss recent developments in metabolomic analysis, from the perspective of trypanosome research, highlighting remaining challenges and the most promising areas for future research.

Keywords

Metabolomicsmass spectrometryOrbitrapab initio networksTrypanosoma brucei
Type
Research Article
Information
Parasitology , Volume 137 , Special Issue 9: Insights into the metabolomes of parasites , August 2010 , pp. 1285 - 1290
Copyright
Copyright © Cambridge University Press 2010

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