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Measuring immune selection

Published online by Cambridge University Press:  29 May 2003

D. J. CONWAY  and
S. D. POLLEY
D. J. CONWAY
Affiliation:
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel St, London WC1E 7HT
S. D. POLLEY
Affiliation:
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel St, London WC1E 7HT
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Abstract

Immune responses that kill pathogens or reduce their reproductive rate are generally important in protecting hosts from infection and disease. Pathogens that escape the full impact of such responses will survive, and any heritable genetic basis of this evasion will be selected. Due to the memory component of vertebrate immune responses, pathogens with rare alleles of a target antigen can have an advantage over those with common alleles, leading to the maintenance of a polymorphism. At the genetic level, there ought to be detectable signatures of balancing selection in the genes encoding these antigens. Here, methods for identifying these selective signatures are reviewed. Their practical utility for identifying which antigens are targets of protective immune responses is discussed.

Keywords

Antigensgenesprotective immunitynatural selectiontests of neutrality
Type
Research Article
Information
Parasitology , Volume 125 , Issue 7 , May 2002 , pp. S3 - S16
Copyright
© 2002 Cambridge University Press

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