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The malaria merozoite, forty years on

Published online by Cambridge University Press:  03 August 2009

L. H. BANNISTER  and
G. H. MITCHELL
L. H. BANNISTER*
Affiliation:
Centre for Ultrastructural Imaging, Guy's Campus, King's College London, London SE1 1UL, UK
G. H. MITCHELL
Affiliation:
Malaria Laboratory, Department of Immunobiology, Guy's, King's College and St Thomas' Hospitals' School of Medicine, KCL, Borough Wing, Guy's Hospital, Great Maze Pond, London SE1 9RT, UK
*
*Corresponding author: Centre for Ultrastructural Imaging, Guy's Campus, King's College London, London SE1 1UL, UK. Tel: +44(0)2086533042. E-mail: [email protected]
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Summary

The invasive blood stage of malaria parasites, merozoites, are complex entities specialized for the capture and entry of red blood cells. Their potential for vaccination and other anti-malaria strategies have attracted much research attention over the last 40 years, and there is now a considerable body of data relating to their biology. In this article some of the major advances over this period and remaining challenges are reviewed.

Keywords

Plasmodiummalariamerozoitevaccinationmicroscopycell biologyinvasionhistory
Type
Research Article
Information
Parasitology , Volume 136 , Special Issue 12: Special Centenary Issue – Parasitology 1908–2008 , October 2009 , pp. 1435 - 1444
Copyright
Copyright © Cambridge University Press 2009

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