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Lyme borreliosis in Europe and North America

Published online by Cambridge University Press:  19 April 2005

J. PIESMAN  and
L. GERN
J. PIESMAN
Affiliation:
Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, PO Box 2087, Fort Collins, CO 80522, USA
L. GERN
Affiliation:
Institut de Zoologie, University of Neuchâtel, Emile-Argand 11, 2007 Neuchâtel 7, Switzerland
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Abstract

Since the discovery of the Lyme disease spirochete in North America in 1982 and in Europe in 1983, a plethora of studies on this unique group of spirochetes that comprise Borrelia burgdorferi sensu lato has been accumulated. In an attempt to compare and contrast Lyme borreliosis in Europe and North America we have reviewed the biology of the aetiologic agents, as well as the clinical aspects, diagnosis and treatment of this disease on both continents. Moreover, we have detailed the ecology of the Ixodes ticks that transmit this infection and the reservoir hosts that maintain the spirochete cycle in nature. Finally, we have examined the transmission dynamics of the spirochete on both continents, as well as the available prevention strategies. Although it has been over two decades since the discovery of the Lyme disease spirochete, Lyme borreliosis is an expanding public health problem that has defied our attempts to control it. By comparing the accumulated experience of investigators in North America and Europe, where the disease is most frequently reported, we hope to advance the cause of developing novel approaches to combat Lyme borreliosis.

Keywords

Lyme borreliosisIxodesticksBorrelia burgdorferi
Type
Research Article
Information
Parasitology , Volume 129 , Issue S1 , October 2004 , pp. S191 - S220
Copyright
© 2004 Cambridge University Press

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References

REFERENCES

AESCHLIMANN, A., CHAMOT, E., GIGON, F., JEANNERET, J. P., KESSELER, D. & WALTHER, C. ( 1986). B. burgdorferi in Switzerland. Zentralblatt für Bakteriologie, Mikrobiologie und Hygiene A 263, 450–458.Google Scholar
ALEKSEEV, A. N., DUBININA, H. V., VAN DE POL, I. & ACHOULS, L. M. ( 2001). Identification of Ehrlichia spp. and Borrelia burgdorferi in Ixodes ticks in the Baltic regions of Russia. Journal of Clinical Microbiology 39, 2237–2242.Google Scholar
ALLAN, S. A. & PATRICAN, L. A. ( 1995). Reduction of immature Ixodes scapularis (Acari: Ixodidae) in woodlots by application of desiccant and insecticidal soap formulations. Journal of Medical Entomology 32, 16–20.CrossRefGoogle Scholar
ANDERSON, J. F. ( 1991). Epizootiology of Lyme borreliosis. Scandinavian Journal of Infectious Diseases Supplement 77, 23–34.Google Scholar
ANDERSON, J. F., JOHNSON, R. C., MAGNARELLI, L. A., HYDE, F. W. & MYERS, J. E. ( 1987). Prevalence of Borrelia burgdorferi and Babesia microti in mice on islands inhabited by white-tailed deer. Applied and Environmental Microbiology 53, 892–894.Google Scholar
ANDERSON, J. F. & MAGNARELLI, L. A. ( 1984). Avian and mammalian hosts for spirochete-infected ticks and insects in a Lyme disease focus in Connecticut. Yale Journal of Biology and Medicine 57, 627–641.Google Scholar
ANDERSON, J. F., MAGNARELLI, L. A. & STAFFORD, K. C. III ( 1990). Bird-feeding ticks transstadially transmit Borrelia burgdorferi that infect Syrian hamsters. Journal of Wildlife Diseases 26, 1–10.CrossRefGoogle Scholar
APPEL, M. J., ALLAN, S., JACOBSON, R. H., LAUDERDALE, T. L., CHANG, Y. F., SHIN, S. J., THOMFORD, J. W., TODHUNTER, R. J. & SUMMERS, B. A. ( 1993). Experimental Lyme disease in dogs produces arthritis and persistent infection. Journal of Infectious Diseases 167, 651–664.CrossRefGoogle Scholar
APPERSON, C. S., LEVINE, J. F., EVANS, T. L., BRASWELL, A. & HELLER, J. ( 1993). Relative utilization of reptiles and rodents as hosts by immature Ixodes scapularis (Acari: Ixodidae) in the coastal plain of North Carolina, USA. Experimental and Applied Acarology 17, 719–731.Google Scholar
ASSOUS, M. V. D., POSTIC, D., PAUL, G., NEVOT, P. & BARANTON, G. ( 1993). Western blot analysis of sera from Lyme borreliosis patients according to the genomic species of the Borrelia strains used as antigens. European Journal of Clinical Microbiology and Infectious Diseases 12, 261–268.CrossRefGoogle Scholar
BAILLY-CHOUMARA, H., MOREL, P. C. & RAGEAU, J. ( 1974). Première contribution au catalogue des tiques du Maroc (Acari: Ixodidae). Bulletin de la Société des Sciences Naturelles du Maroc 54, 71–80.Google Scholar
BALMELLI, T. & PIFFARETTI, J. C. ( 1995). Association between different clinical manifestations of Lyme disease and different species of Borrelia burgdorferi sensu lato. Research in Microbiology 146, 329–340.CrossRefGoogle Scholar
BARANTON, G., POSTIC, D., SAINT GIRONS, I., BOERLIN, P., PIFFARETTI, J. C., ASSOUS, M. & GRIMONT, P. A. D. ( 1992). Delineation of Borrelia burgdorferi sensu stricto, Borrelia garinii sp. nov.; and group VS461 associated with Lyme borreliosis. International Journal of Systematic Bacteriology 42, 378–383.Google Scholar
BARANTON, G., SEINOST, G., THEODORE, G., POSTIC, D. & DYKHUISEN, D. ( 2001). Distinct levels of genetic diversity of Borrelia burgdorferi are associated with different aspects of pathogenicity. Research in Microbiology 152, 149–156.CrossRefGoogle Scholar
BARBOUR, A. G., HEILAND, R. A. & HOWE, T. R. ( 1985). Heterogeneity of major proteins in Lyme disease borreliae: a molecular analysis of North American and European isolates. Journal of Infectious Diseases 152, 478–484.CrossRefGoogle Scholar
BARBOUR, A. G., MAUPIN, G. O., TELTOW, G. J., CARTER, C. J. & PIESMAN, J. ( 1996). Identification of an uncultivable Borrelia species in the hard tick Amblyomma americanum: Possible agent of a Lyme disease-like illness. Journal of Infectious Diseases 173, 403–409.CrossRefGoogle Scholar
BARRAL, M., GARCIA-PEREZ, A. L., JUSTE, R. A., HURTADO, A., ESCUDERO, R., SELLEK, R. E. & ANDA, P. ( 2002). Distribution of Borrelia burgdorferi sensu lato in Ixodes ricinus (Acari[ratio ]Ixodidae) ticks from the Basque Country, Spain. Journal of Medical Entomology 39, 177–184.CrossRefGoogle Scholar
BASTA, J., PLCH, J., HULINSKA, D. & DANIEL, M. ( 1999). Incidence of Borrelia garinii and Borrelia afzelii in Ixodes ricinus ticks in an urban environment, Prague, Czech Republic, between 1995 and 1998. European Journal of Clinical Microbiology and Infectious Diseases 18, 515–517.Google Scholar
BATTALY, G. R. & FISH, D. ( 1993). Relative importance of bird species as hosts for immature Ixodes dammini (Acari: Ixodidae) in a suburban residential landscape of southern New York State. Journal of Medical Entomology 30, 740–747.CrossRefGoogle Scholar
BENJAMIN, M. A., ZHIOUA, E. & OSTFELD, R. S. ( 2002). Laboratory and field evaluation of the entomopathogenic fungus Metarhizium anisopliae (Deuteromycetes) for controlling questing adult Ixodes scapularis (Acari: Ixodidae). Journal of Medical Entomology 39, 723–728.CrossRefGoogle Scholar
BERGER, B. W., JOHNSON, R. C., KODNER, C. & COLEMAN, L. ( 1992). Cultivation of Borrelia burgdorferi from erythema migrans lesions and perilesional skin. Journal of Clinical Microbiology 30, 359–361.Google Scholar
BUCHWALD, A. ( 1883). Ein Fall von diffuser idiopathischer Hautatrophie. Vierteljahrschrift für Dermatologie 15, 553–556.Google Scholar
BURGDORFER, W. ( 2001). Arthropod-borne spirochetoses: A historical perspective. European Journal of Clinical Microbiology and Infectious Disease 20, 1–5.CrossRefGoogle Scholar
BURGDORFER, W., BARBOUR, A. G., HAYES, S. F., BENACH, J. L., GRUNWALDT, E. & DAVIS, J. P. ( 1982). Lyme disease. A tick-borne spirochetosis? Science 216, 1317–1319.Google Scholar
BURGDORFER, W., BARBOUR, A. G., HAYES, S. F., PETER, O. & AESCHLIMANN, A. ( 1983). Erythema migrans – A tick-borne spirochetosis. Acta Tropica 40, 79–83.Google Scholar
BURKOT, T. R., CLOVER, J. R., HAPP, C. M., DeBESS, E. & MAUPIN, G. O. ( 1999). Isolation of Borrelia burgdorferi from Neotoma fuscipes, Peromyscus maniculatus, Peromyscus boylii, and Ixodes pacificus in Oregon. American Journal of Tropical Medicine and Hygiene 60, 453–457.CrossRefGoogle Scholar
BUSCH, U., HIZO-TEUFEL, C., BOEHMER, R., FINGERLE, V., NITSCHKO, H., WILSKE, B. & PREAC-MURSIC, V. ( 1996 a). Three species of Borrelia burgdorferi sensu lato (B. burgdorferi sensu stricto, B. afzelii and B. garinii) identified from cerebrospinal fluid isolates by pulsed-fied gel electrophoresis and PCR. Journal of Clinical Microbiology 34, 1072–1078.Google Scholar
BUSCH, U., HIZO-TEUFEL, C., BOEHMER, R., FINGERLE, V., ROESSLER, D., WILSKE, B. & PREAC-MURSIC, V. ( 1996 b). Borrelia burgdorferi sensu lato strains isolated from cutaneous Lyme borreliosis biopsies differentiated by pulsed-field gel electrophoresis. Scandinavian Journal of Infectious Diseases 28, 583–589.Google Scholar
CANICA, M. M., NATO, F., DU MERLE, L., MAZIE, J. C., BARANTON, G. & POSTIC, D. ( 1993). Monoclonal antibodies for identification of Borrelia afzelii sp. nov. associated with late cutaneous manifestations of Lyme borreliosis. Scandinavian Journal of Infectious Diseases 25, 441–448.Google Scholar
CENTERS FOR DISEASE CONTROL AND PREVENTION ( 1995). Recommendations for test performance and interpretation from the Second National Conference on Serologic Diagnosis of Lyme Disease. Morbidity and Mortality Weekly Report 44, 590–591.
CHANG, Y. F., NOVOSOL, V., McDONOUGH, S. P., CHANG, C. F., JACOBSON, R. H., DIVERS, T., QUIMBY, F. W., SHIN, S. & LEIN, D. H. ( 2000). Experimental infection of ponies with Borrelia burgdorferi by exposure to Ixodid ticks. Veterinary Pathology 37, 68–76.CrossRefGoogle Scholar
CINCO, M., PADOVAN, D., MURGIA, R., POLDINI, L., FRUSTERI, L., VAN DE POL, I., VERBEEK-DE KRUIF, N., RIJPKEMA, S. G. & MARIOLI, M. ( 1998). Rate of infection of Ixodes ricinus ticks with Borrelia burgdorferi sensu stricto, Borrelia garinii, Borrelia afzelii and group VS116 in an endemic focus of Lyme disease in Italy. European Journal of Clinical Microbiology and Infectious Diseases 17, 90–94.CrossRefGoogle Scholar
CRAINE, N. G., NUTTALL, A. C., MARRIOTT, A. C. & RANDOLPH, S. E. ( 1997). Role of grey squirrels and pheasants in the transmission of Borrelia burgdorferi sensu lato, the Lyme disease spirochaete, in the UK. Folia Parasitologica 44, 155–160.Google Scholar
CRIPPA, M., RAIS, O. & GERN, L. ( 2002). Investigations on the mode and dynamics of transmission and infectivity of Borrelia burgdorferi sensu stricto and Borrelia afzelii in Ixodes ricinus ticks. Vector Borne and Zoonotic Diseases 2, 3–9.CrossRefGoogle Scholar
CURRAN, K. L., FISH, D. & PIESMAN, J. ( 1993). Reduction of nymphal Ixodes dammini (Acari: Ixodidae) in a residential suburban landscape by area application of insecticides. Journal of Medical Entomology 30, 107–113.CrossRefGoogle Scholar
CUTLER, S. J., WILLIAMS, N. G. & WRIGHT, D. J. M. ( 1989). Borrelia species from an endemic area for Lyme disease in the United Kingdom. 4th European Congress of Clinical Microbiology. Nice, France. Abstract 908.
DANCHIN, E., BOULINIER, T. & MASSOT, M. ( 1998). Conspecific reproductive success and breeding habitat selection: implications for the study of coloniality. Ecology 79, 2415–2428.CrossRefGoogle Scholar
DANIELS, T. J. & FISH, D. ( 1995). Effect of deer exclusion on the abundance of immature Ixodes scapularis (Acari: Ixodidae) parasitizing small and medium-sized mammals. Journal of Medical Entomology 32, 5–11.CrossRefGoogle Scholar
DANIELS, T. J., FISH, D. & FALCO, R. C. ( 1991). Evaluation of host-targeted acaricide for reducing risk of Lyme disease in southern New York State. Journal of Medical Entomology 28, 537–543.CrossRefGoogle Scholar
DAVEY, R. B., AHRENS, E. H., GEORGE, J. E., HUNTER, J. S. 3rd & JEANNIN, P. ( 1998). Therapeutic and persistent efficacy of fipronil against Boophilus microplus (Acari: Ixodidae) on cattle. Veterinary Parasitology 74, 261–276.CrossRefGoogle Scholar
DEBLINGER, R. D. & RIMMER, D. W. ( 1991). Efficacy of a permethrin-based acaricide to reduce the abundance of Ixodes dammini (Acari: Ixodidae). Journal of Medical Entomology 28, 708–711.CrossRefGoogle Scholar
DEBLINGER, R. D., WILSON, M. L., RIMMER, D. W. & SPIELMAN, A. ( 1993). Reduced abundance of immature Ixodes dammini (Acari: Ixodidae) following incremental removal of deer. Journal of Medical Entomology 30, 144–150.CrossRefGoogle Scholar
DE BOER, R., HOVIUS, K. E., NOHLMANS, M. K. E. & GRAY, J. S. ( 1993). The woodmouse (Apodemus sylvaticus) as a reservoir of tick-transmitted spirochetes (Borrelia burgdorferi) in the Netherlands. Zentralblatt für Bakteriologie 279, 404–416.CrossRefGoogle Scholar
DE MICHELIS, S., SEWELL, H. S., COLLARES-PEREIRA, M., SANTOS-REIS, M., SCHOULS, L. E., BENES, V., HOLMES, E. C. & KURTENBACH, K. ( 2000). Genetic diversity of Borrelia burgdorferi sensu lato in ticks from mainland Portugal. Journal of Clinical Microbiology 38, 2118–2133.Google Scholar
DENNIS, D., NEKOMOTO, T. S., VICTOR, J. C., PAUL, W. S. & PIESMAN, J. ( 1998). Reported distribution of Ixodes scapularis and Ixodes pacificus (Acari: Ixodidae) in the United States. Journal of Medical Entomology 35, 629–638.CrossRefGoogle Scholar
DES VIGNES, F., PIESMAN, J., HEFFERNAN, R., SCHULZE, T. L., STAFFORD, K. C. III & FISH, D. ( 2001). Effect of tick removal on transmission of Borrelia burgdorferi and Ehrlichia phagocytophila by Ixodes scapularis nymphs. Journal of Infectious Diseases 183, 773–778.Google Scholar
DISTER, S. W., FISH, D., BROS, S. M., FRANK, D. H. & WOOD, B. L. ( 1997). Landscape characterization of peridomestic risk for Lyme disease using satellite imagery. American Journal of Tropical Medicine and Hygiene 57, 687–692.CrossRefGoogle Scholar
DIZIJ, A. & KURTENBACH, K. ( 1995). Clethrionomys glareolus, but not Apodemus flavicollis, acquires resistance to Ixodes ricinus L., the main European vector of Borrelia burgdorferi. Parasite Immunology 17, 177–183.Google Scholar
DONNELLY, J. ( 1976). The life cycle of Ixodes ricinus L. based on recent published findings. In Tick-Borne Diseases and their Vectors ( ed. Wilde, J. K. H.), pp. 56–60. CTVM, University of Edinburgh, Edinburgh.
DRESSLER, F., ACKERMANN, R. & STEERE, A. C. ( 1994). Antibody responses to the three genomic groups of Borrelia burgdorferi in European Lyme borreliosis. Journal of Infectious Diseases 169, 313–318.CrossRefGoogle Scholar
DRESSLER, F., WHALEN, J. A., REINHARDT, B. N. & STEERE, A. C. ( 1993). Western blotting in the serodiagnosis of Lyme disease. Journal of Infectious Diseases 167, 392–400.CrossRefGoogle Scholar
DUFFY, D. C., CAMPBELL, S. R., CLARK, D., DiMOTTA, C. & GURNEY, S. ( 1994). Ixodes scapularis (Acari: Ixodidae) deer tick mesoscale populations in natural areas: effects of deer, area, and location. Journal of Medical Entomology 31, 152–158.CrossRefGoogle Scholar
DWORKIN, M. S., SHOEMAKER, P. C., FRITZ, C. L., DOWELL, M. E. & ANDERSON, D. E. Jr. ( 2002). The epidemiology of tick-borne relapsing fever in the United States. American Journal of Tropical Medicine and Hygiene 66, 753–758.CrossRefGoogle Scholar
EIFFERT, H., KARSTEN, A., THOMSSEN, R. & CHRISTEN, H. J. ( 1998). Characterization of Borrelia burgdorferi strains in Lyme arthritis. Scandinavian Journal of Infectious Diseases 30, 265–268.Google Scholar
ESCUDERO, R., BARRAL, M., PEREZ, A., VITUTIA, M. M., GARCIA-PEREZ, A. L., JIMENEZ, S., SELLEK, R. E. & ANDA, P. ( 2000). Molecular and pathogenic characterization of Borrelia burgdorferi sensu lato isolates from Spain. Journal of Clinical Microbiology 38, 4026–4033.Google Scholar
EVELEIGH, E. S. & THRELFALL, W. ( 1974). The biology of Ixodes (Ceratoixodes) uriae White, 1852 in Newfoundland. Acarologia 16, 621–635.Google Scholar
FALCO, R. C., FISH, D. & PIESMAN, J. ( 1996). Duration of tick bites in a Lyme disease-endemic area. American Journal of Epidemiology 143, 187–192.CrossRefGoogle Scholar
FALCO, R. C., McKENNA, D. F., DANIELS, T. J., NADELMAN, R. B., NOWAKOWSKI, J., FISH, D. & WORMSER, G. P. ( 1999). Temporal relationship between Ixodes scapularis abundance and risk for Lyme disease associated with erythema migrans. American Journal of Epidemiology 149, 771–776.CrossRefGoogle Scholar
FELSENFELD, O. ( 1979). Borrelia. In CRC Handbook Series in Zoonoses. Section A. Bacterial, Rickettsial, and Mycotic Diseases. Vol. 1 ( ed. J. H. Steele), pp. 79–96. CRC Press, Boca Raton, Florida.
FINGERLE, V., RAUSER, S., HAMMER, B., KAHL, O., HEIMERL, C., SCHULTE-SPECHTEL, U., GERN, L. & WILSKE, B. ( 2002). Dynamics of dissemination and outer surface protein expression of different Borrelia burgdorferi s.l. strains in artificially infected Ixodes ricinus nymphs. Journal of Clinical Microbiology 40, 1456–1463.Google Scholar
FISH, D. & DOWLER, R. C. ( 1989). Host associations of ticks (Acari: Ixodidae) parasitizing medium-sized mammals in a Lyme disease endemic area of southern New York. Journal of Medical Entomology 26, 200–209.CrossRefGoogle Scholar
FRAENKEL, C.-J., GARPMO, U. & BERGLUND, J. ( 2002). Determination of novel Borrelia genospecies in Swedish Ixodes ricinus ticks. Journal of Clinical Microbiology 40, 3308–3312.CrossRefGoogle Scholar
FUKUNAGA, M., TAKAHASHI, Y., TSURUTA, Y., MATSUSHITA, O., RALPH, D., McCLELLAND, M. & NAKAO, M. ( 1995). Genetic and phenotypic analysis of Borrelia miyamotoi sp. nov., isolated from the ixodid tick Ixodes persulcatus, the vector for Lyme disease in Japan. International Journal of Systematic Bacteriology 45, 804–810.Google Scholar
FUKUNAGA, M., USHIJIMA, Y., AOKI, L. Y. & TALBERT, A. ( 2001). Detection of Borrelia duttonii, a tick-borne relapsing fever agent in central Tanzania, within ticks by flagellin gene-based nested polymerase chain reaction. Vector Borne Zoonotic Diseases 1, 331–338.CrossRefGoogle Scholar
GAGE, K. L., MAUPIN, G. O., MONTIENERI, J., PIESMAN, J., DOLAN, M. C. & PANELLA, N. A. ( 1997). Flea (Siphonaptera: Ceratophyllidae, Hystrichopsyllidae) and tick (Acarina: Ixodidae) control on wood rats using host-targeted liquid permethrin in bait tubes. Journal of Medical Entomology 34, 46–51.CrossRefGoogle Scholar
GERN, L., ESTRADA-PENA, A., FRANDSEN, F., GRAY, J. S., JAENSON, T. G. T., JONGEJAN, F., KAHL, O., KORENBERG, E., MEHL, R. & NUTTALL, P. A. ( 1998). European reservoir hosts of Borrelia burgdorferi sensu lato. Zentralblatt für Bakteriologie 287, 196–204.CrossRefGoogle Scholar
GERN, L., HU, C. M., KOCIANOVA, E., VYROSTEKOVA, V. & REHACEK, J. ( 1999). Genetic diversity of Borrelia burgdorferi sensu lato isolates obtained from Ixodes ricinus ticks collected in Slovakia. European Journal of Epidemiology 15, 665–669.CrossRefGoogle Scholar
GERN, L., HU, C. M., VOET, P., HAUSER, P. & LOBET, Y. ( 1997). Immunization with a polyvalent OspA vaccine protects mice against Ixodes ricinus tick bites infected by Borrelia burgdorferi ss, B. garinii and B. afzelii. Vaccine 15, 1551–1557.Google Scholar
GERN, L. & HUMAIR, P. F. ( 2002). Ecology of Borrelia burgdorferi sensu lato in Europe. In Lyme Borreliosis: Biology, Epidemiology and Control ( ed. Gray, J., Kahl, O., Lane, R. S. & Stanek, G.), pp. 149–174. CABI International, Wallingford, Oxford, UK.CrossRef
GERN, L., LEBET, N. & MORET, J. ( 1996). Dynamics of Borrelia burgdorferi infection in nymphal Ixodes ricinus ticks during feeding. Experimental and Applied Acarology 20, 649–658.CrossRefGoogle Scholar
GERN, L. & RAIS, O. ( 1996). Efficient transmission of Borrelia burgdorferi between cofeeding Ixodes ricinus ticks (Acari: Ixodidae). Journal of Medical Entomology 33, 189–192.CrossRefGoogle Scholar
GERN, L., ROUVINEZ, E., TOUTOUNGI, L. N. & GODFROID, E. ( 1997). Transmission cycles of Borrelia burgdorferi sensu lato involving Ixodes ricinus and/or I. hexagonus ticks and the European hedgehog, Erinaceus europaeus, in suburban and urban areas in Switzerland. Folia Parasitologica 44, 309–314.Google Scholar
GERN, L., SIEGENTHALER, M., HU, C. M., LEUBA-GARCIA, S., HUMAIR, P. F. & MORET, J. ( 1994). Borrelia burgdorferi in rodents (Apodemus flavicollis and A. sylvaticus): duration and enhancement of infectivity for Ixodes ricinus ticks. European Journal of Epidemiology 10, 75–80.Google Scholar
GERN, L., YOUNSI, H., GODFROID, E., SARIH, M., POSTIC, D., BOUATTOUR, A., JOUDA, F., ALEM, A. & NUNCIO, S. ( 2002). Lyme borreliosis in North Africa. IX International Conference on Lyme borreliosis and Other Tick-borne Diseases (ed. Wormser, G. P.). New York, NY, USA. Abstract 138.
GERN, L., ZHU, Z. & AESCHLIMANN, A. ( 1990). Development of Borrelia burgdorferi in Ixodes ricinus females during blood feeding. Annales de Parasitologie Humaine et Comparée 65, 89–94.CrossRefGoogle Scholar
GODDARD, J. ( 1992). Ecological studies of adult Ixodes scapularis in central Mississippi: questing activity in relation to time of year, vegetation type, and meteorologic conditions. Journal of Medical Entomology 29, 501–506.CrossRefGoogle Scholar
GORELOVA, N. B., KORENBERG, E. I., KOVALEVSKII, Y. V., POSTIC, D. & BARANTON, G. ( 1996). The isolation of Borrelia from the tick Ixodes trianguliceps (Ixodidae) and the possible significance of this species in the epizootiology of ixodid tick-borne borrelioses. [In Russian.] Parazitologiia 30, 13–18.Google Scholar
GORELOVA, N. B., KORENBERG, E. I., KOVALEVSKII, Y. V. & SHCHERBAKOV, S. V. ( 1995). Small mammals as reservoir hosts for Borrelia in Russia. Zentralblatt für Bakteriologie 282, 315–322.CrossRefGoogle Scholar
GRAY, J. S. ( 1982). The development and questing activity of Ixodes ricinus (L.) (Acari: Ixodidae) under field conditions in Ireland. Bulletin of Entomological Research 72, 263–270.Google Scholar
GRAY, J. S. ( 1985). Studies on the larval activity of the tick Ixodes ricinus (L.) in Co. Wicklow, Ireland. Experimental and Applied Acarology 1, 307–316.CrossRefGoogle Scholar
GRAY, J. S. ( 1991). The development and seasonal activity of the tick Ixodes ricinus (L.) a vector of Lyme borreliosis. Review of Medical and Veterinary Entomology 79, 323–333.Google Scholar
GRAY, J. S., GRANSTRÖM, M., CIMMINO, M., DANIEL, M., GETTINBY, G., KAHL, O., JAENSON, T. G. T., JONGEJAN, F., KORENBERG, E. & O'CONNELL, S. ( 1998). Lyme Borreliosis awareness. Zentralblatt für Bakteriologie 287, 253–265.CrossRefGoogle Scholar
GRAY, J. S., KAHL, O., JANETZKI, C. & STEIN, J. ( 1992). Studies on the ecology of Lyme disease in a deer forest in County Galway, Ireland. Journal of Medical Entomology 29, 915–920.CrossRefGoogle Scholar
GRAY, J. S., KAHL, O., JANETZKI-MITTMAN, C., STEIN, J. & GUY, E. ( 1994). Acquisition of Borrelia burgdorferi by Ixodes ricinus ticks fed on the European hedgehog, Erinaceus europaeus L. Experimental and Applied Acarology 18, 485–491.CrossRefGoogle Scholar
GRAY, J. S., KAHL, O., JANETZKI, C., STEIN, J. & GUY, E. ( 1995). The spatial distribution of Borrelia burgdorferi-infected Ixodes ricinus in the Connemara region of Co. Galway, Ireland. Experimental and Applied Acarology 18, 485–491.Google Scholar
GROSS, D. M., FORSTHUBER, T., TARY-LEHMANN, M., ETLING, C., ITO, K., NAGY, Z. A., FIELD, J. A., STEERE, A. C. & HUBER, B. T. ( 1998). Identification of LFA-1 as a candidate autoantigen in treatment-resistant Lyme arthritis. Science 281, 703–706.CrossRefGoogle Scholar
GUERRA, M., WALKER, E., JONES, C., PASKEWITZ, S., CORTINAS, M. R., STANCIL, A., BECK, L., BOBO, M. & KITRON, U. ( 2002). Predicting the risk of Lyme disease: habitat suitability for Ixodes scapularis in the north central United States. Emerging Infectious Diseases 8, 289–297.CrossRefGoogle Scholar
GYLFE, Å., BERGSTRÖM, S., LUNSTROM, J. & OLSEN, B. ( 2000). Epidemiology – Reactivation of Borrelia infection in birds. Nature 403, 724–725.CrossRefGoogle Scholar
GYLFE, Å., OLSEN, B., STRASEVICIUS, D., RAS, N. M., WEIHE, P., NOPPA, L., OSTBERG, Y., BARANTON, G. & BERGSTRÖM, S. ( 1999). Isolation of Lyme disease Borrelia from puffins (Fratercula arctica) and seabird ticks (Ixodes uriae) on the Faroe Islands. Journal of Clinical Microbiology 37, 890–896.Google Scholar
HALPERIN, J. J., LUFT, B. J., ANAND, A. K., ROQUE, C. T., ALVAREZ, O., VOLKMAN, D. J. & DATTWYLER, R. J. ( 1989). Lyme neuroborreliosis: central nervous system manifestations. Neurology 39, 753–759.CrossRefGoogle Scholar
HANINCOVÁ, K., SCHÄFER, S. M., ETTI, S., SEWELL, H. S., TARAGELOVÁ, V., ZIAK, D., LABUDA, M. & KURTENBACH, K. ( 2003 a). Association of Borrelia afzelii with rodents in Europe. Parasitology 126, 11–20.Google Scholar
HANINCOVÁ, K., TARAGELOVÁ, V., KOCI, J., SCHÄFER, S. M., HAILS, R., ULLMANN, A. J., PIESMAN, J., LABUDA, M. & KURTENBACH, K. ( 2003 b). Association of Borrelia garinii and B. valaisiana with songbirds in Slovakia. Applied and Environmental Microbiology 69, 2825–2830.Google Scholar
HAUSER, U., KRAHL, H., PETERS, H., FINGERLE, V. & WILSKE, B. ( 1998). Impact of strain heterogeneity on Lyme disease serology in Europe: Comparison of enzyme-linked immunosorbent assays using different species of Borrelia burgdorferi sensu lato. Journal of Clinical Microbiology 36, 427–436.Google Scholar
HAYES, E. B. & PIESMAN, J. ( 2003). How can we prevent Lyme Disease? New England Journal of Medicine 348, 2424–2430.Google Scholar
HERRINGTON, J. E. Jr., CAMPBELL, G. L., BAILEY, R. E., CARTTER, M. L., ADAMS, M., FRAZIER, E. L., DAMROW, T. A. & GENSHEIMER, K. F. ( 1997). Predisposing factors for individuals' Lyme disease prevention practices: Connecticut, Maine, and Montana. American Journal of Public Health 87, 2035–2038.CrossRefGoogle Scholar
HILLYARD, P. D. ( 1996). Ticks of North-West Europe ( ed. Barnes, R. S. K. & Crothers, J. H.), Vol. 52, pp. 178. Field Studies Council, Shrewsbury, United Kingdom.
HU, C. M., HUMAIR, P. F., WALLICH, R. & GERN, L. ( 1997). Apodemus sp. rodents, reservoir hosts for Borrelia afzelii in an endemic area in Switzerland. Zentralblatt für Bakteriologie 285, 558–564.Google Scholar
HU, C. M., WILSKE, B., FINGERLE, V., LOBET, Y. & GERN, L. ( 2001). Transmission of Borrelia garinii OspA serotype 4 to BALB/c mice by Ixodes ricinus ticks collected in the field. Journal of Clinical Microbiology 39, 1169–1171.CrossRefGoogle Scholar
HUBÁLEK, Z., ANDERSON, J. F., HALOUZKA, J. & HÁJEK, V. ( 1996). Borreliae in immature Ixodes ricinus (Acari: Ixodidae) ticks parasitizing birds in the Czech Republic. Journal of Medical Entomology 33, 766–771.CrossRefGoogle Scholar
HUBÁLEK, Z. & HALOUZKA, J. ( 1997). Distribution of Borrelia burgdorferi sensu lato genomic groups in Europe, a review. European Journal of Epidemiology 13, 951–957.CrossRefGoogle Scholar
HUBÁLEK, Z. & HALOUZKA, J. ( 1998). Prevalence rates of Borrelia burgdorferi sensu lato in host-seeking Ixodes ricinus ticks in Europe. Parasitology Research 84, 167–172.CrossRefGoogle Scholar
HUBBARD, M. J., BAKER, A. S. & CANN, K. J. ( 1998). Distribution of Borrelia burgdorferi s.l. spirochaete DNA in British ticks (Argasidae and Ixodidae) since the 19th century, assessed by PCR. Medical and Veterinary Entomology 12, 89–97.Google Scholar
HUEGLI, D., HU, C. M., HUMAIR, P.-F., WILSKE, B. & GERN, L. ( 2002). Apodemus species mice, reservoir hosts of Borrelia garinii OspA serotype 4 in Switzerland. Journal of Clinical Microbiology 40, 4735–4737.CrossRefGoogle Scholar
HUMAIR, P. F. ( 2002). Birds and Borrelia. International Journal of Medical Microbiology 291, 70–74.CrossRefGoogle Scholar
HUMAIR, P. F. & GERN, L. ( 1998). Relationship between Borrelia burgdorferi sensu lato species, red squirrels (Sciurus vulgaris) and Ixodes ricinus in enzootic areas in Switzerland. Acta Tropica 69, 213–227.CrossRefGoogle Scholar
HUMAIR, P. F., PÉTER, O., WALLICH, R. & GERN, L. ( 1995). Strain variation of Lyme disease spirochetes isolated from Ixodes ricinus ticks and rodents collected in two endemic areas in Switzerland. Journal of Medical Entomology 32, 433–438.CrossRefGoogle Scholar
HUMAIR, P. F., POSTIC, D., WALLICH, R. & GERN, L. ( 1998). An avian reservoir (Turdus merula) of the Lyme borreliosis spirochetes. Zentralblatt für Bakteriologie 287, 521–538.Google Scholar
HUMAIR, P. F., RAIS, O. & GERN, L. ( 1999). Transmission of Borrelia afzelii from Apodemus mice and Clethrionomys voles to Ixodes ricinus ticks: differential transmission pattern and overwintering maintenance. Parasitology 118, 33–42.CrossRefGoogle Scholar
HUMAIR, P. F., TURRIAN, N., AESCHLIMANN, A. & GERN, L. ( 1993 a). Borrelia burgdorferi in a focus of Lyme borreliosis: epizootiologic contribution of small mammals. Folia Parasitologica 40, 65–70.Google Scholar
HUMAIR, P. F., TURRIAN, N., AESCHLIMANN, A. & GERN, L. ( 1993 b). Ixodes ricinus immatures on birds in a focus of Lyme borreliosis. Folia Parasitologica 40, 237–242.Google Scholar
JAENSON, T. G. T. & TÄLLEKLINT, L. ( 1992). Incompetence of roe deer as reservoirs of the Lyme borreliosis spirochete. Journal of Medical Entomology 29, 813–817.CrossRefGoogle Scholar
JAENSON, T. G. T. & TÄLLEKLINT, L. ( 1996). Lyme borreliosis spirochetes in Ixodes ricinus (Acari: Ixodidae) and the varying hare on isolated islands in the Baltic sea. Journal of Medical Entomology 33, 339–343.CrossRefGoogle Scholar
JAENSON, T. G. T., TÄLLEKLINT, L., LUNDQVIST, L., OLSEN, B., CHIRICO, J. & MEJLON, H. ( 1994). Geographical distribution, host associations and vector roles of ticks (Acari: Ixodidae, Argasidae) in Sweden. Journal of Medical Entomology 31, 240–256.CrossRefGoogle Scholar
JAMES, A. M., LIVERIS, D., WORMSER, G. P., SCHWARTZ, I., MOTECALVO, M. A. & JOHNSON, B. J. ( 2001). Borrelia lonestari infection after a bite by an Amblyomma americanum tick. Journal of Infectious Diseases 183, 1810–1814.CrossRefGoogle Scholar
JAULHAC, B., HELLER, R., LIMBACH, F. X., HANSMANN, Y., LIPSKER, D., MONTEIL, H., SIBILIA, J. & PIEMONT, Y. ( 2000). Direct molecular typing of Borrelia burgdorferi sensu lato species in synovial samples from patients with Lyme arthritis. Journal of Clinical Microbiology 38, 1895–1900.Google Scholar
JENKINS, A., KRISTIANSEN, B. E., ALLUM, A. G., AAKRE, R. K., STRAND, L., KLEVELAND, E. J., VAN DE POL, I. & SCHOULS, L. ( 2001). Borrelia burgdorferi sensu lato and Ehrlichia spp. in Ixodes ticks from southern Norway. Journal of Clinical Microbiology 39, 3666–3671.Google Scholar
JOHNSON, B. J., ROBBINS, K. E., BAILEY, R. E., CAO, B. L., SVIAT, S. L., CRAVEN, R. B., MAYER, L. W. & DENNIS, D. T. ( 1996). Serodiagnosis of Lyme disease: Accuracy of a two-step approach using a flagella-based ELISA and immunoblotting. Journal of Infectious Diseases 174, 346–353.CrossRefGoogle Scholar
JOHNSON, R. C., SCHMID, G. P., HYDE, F. W., STIEGERWALT, A. G. & BRENNER, D. J. ( 1984). Borrelia burgdorferi sp. nov.: Etiologic agent of Lyme disease. International Journal of Systematic Bacteriology 34, 496–497.Google Scholar
JONES, C. G., OSTFELD, R. S., RICHARD, M. P., SCHAUBER, E. M. & WOLFF, J. O. ( 1998). Chain reaction linking acorns to gypsy moth outbreaks and Lyme disease risk. Science 279, 1023–1026.CrossRefGoogle Scholar
JOUDA, F., CRIPPA, M., PERRET, J.-L. & GERN, L. ( 2003). Distribution and prevalence of Borrelia burgdorferi sensu lato in Ixodes ricinus ticks of Canton Ticino (Switzerland). European Journal of Epidemiology 18, 907–912.CrossRefGoogle Scholar
JUNTTILA, J., PELTOMAA, M., SOINI, H., MARJAMÄKI, M. & VILJAMNEN, M. K. ( 1999). Prevalence of Borrelia burgdorferi in Ixodes ricinus ticks in urban recreational areas of Helsinki. Journal of Clinical Microbiology 37, 1361–1365.Google Scholar
KAHL, O., GERN, L., EISEN, L. & LANE, R. S. ( 2002). Ecological research on Borrelia burgdorferi sensu lato: Terminology and some methodological pitfalls. In Lyme Borreliosis: Biology, Epidemiology and Control ( ed. Gray, J., Kahl, O., Lane, R. S. & Stanek, G.), pp. 29–46. CABI International, Wallingford, Oxford, UK.CrossRef
KAHL, O. & GEUE, L. ( 1998). Laboratory study on the possible role of the European fox, Vulpes vulpes as a potential reservoir of Borrelia burgdorferi s.l. In 2nd International Conference on Tick-Borne Pathogens at the Host–Vector Interface: a Global Perspective, S.I.: The Conference ( ed. Coons, L. & Rothschild, M.), p. 29. Kruger National Park, South Africa.
KAHL, O., JANETZKI-MITTMANN, C., GRAY, J. S., JONAS, R., STEIN, J. & DE BOER, R. ( 1998). Risk of infection with Borrelia burgdorferi sensu lato for a host in relation to the duration of nymphal Ixodes ricinus feeding and the method of tick removal. Zentralblatt für Bakteriologie 287, 41–52.CrossRefGoogle Scholar
KAHL, O. & KNULLE, W. ( 1988). Water vapour uptake from subsaturated atmospheres by engorged immature ixodid ticks. Experimental and Applied Acarology 4, 73–83.CrossRefGoogle Scholar
KAIN, D. E., SPERLING, F. A. H., DALY, H. V. & LANE, R. S. ( 1999). Mitochondrial DNA sequence variation in Ixodes pacificus (Acari: Ixodidae). Heredity 83, 378–386.CrossRefGoogle Scholar
KAIN, D. E., SPERLING, F. A. H. & LANE, R. S. ( 1997). Population genetic structure of Ixodes pacificus (Acari: Ixodidae) using allozymes. Journal of Medical Entomology 34, 441–450.CrossRefGoogle Scholar
KAZMIERCZAK, J. J., AMUNDSON, T. E. & BURGESS, E. C. ( 1988). Borreliosis in free-ranging black bears from Wisconsin. Journal of Wildlife Diseases 244, 366–368.CrossRefGoogle Scholar
KHANAKAH, G., KMETY, E., RADDA, A. & STANEK, G. ( 1994). Micromammals as reservoir of Borrelia burgdorferi in Austria. In Abstract book of the VI Conference on Lyme Borreliosis ( ed. Cevenini, R., Sambri, V. & La Placa, M.). Bologna, Italy. Abstract P077W.
KIRSTEIN, F., RIJPKEMA, S., MOLKENBOER, M. & GRAY, J. S. ( 1997). The distribution and prevalence of Borrelia burgdorferi genomospecies in Ixodes ricinus ticks in Ireland. European Journal of Epidemiology 13, 67–72.CrossRefGoogle Scholar
KLEMPNER, M. S., HU, L. T., EVANS, J., SCHMID, C. H., JOHNSON, G. M., TREVINO, R. P., NORTON, D., LEVY, L., WALL, D., McCALL, J., KOSINSKI, M. & WEINSTEIN, A. ( 2001). Two controlled trials of antibiotic treatment in patients with persistent symptoms and a history of Lyme disease. New England Journal of Medicine 345, 85–92.CrossRefGoogle Scholar
KORENBERG, E. I. ( 2000). Seasonal population dynamics of Ixodes ticks and tick-borne encephalitis virus. Experimental and Applied Acarology 24, 665–681.CrossRefGoogle Scholar
KORENBERG, E. I., GORELOVA, N. B. & KOVALEVSKII, Y. V. ( 2002). Ecology of Borrelia burgdorferi sensu lato in Russia. In Lyme Borreliosis: Biology, Epidemiology and Control ( ed. Gray, J., Kahl, O., Lane, R. S. & Stanek, G.), pp. 175–200. CABI International, Wallingford, Oxford, UK.CrossRef
KRAICZY, P., SKERKA, C., BRADE, V. & ZIPFEL, P. F. ( 2001). Further characterization of complement regulator – acquiring surface proteins of Borrelia burgdorferi. Infection and Immunity 69, 7800–7809.CrossRefGoogle Scholar
KUO, M. M., LANE, R. S. & GICIAS, P. C. ( 2000). A comparative study of mammalian and reptilian alternative pathway of complement-mediated killing of the Lyme disease spirochete (Borrelia burgdorferi). Journal of Parasitology 86, 1223–1228.CrossRefGoogle Scholar
KURTENBACH, K., CAREY, D., HOODLESS, A. N., NUTTALL, P. A. & RANDOLPH, S. E. ( 1998 a). Competence of pheasants as reservoirs for Lyme disease spirochetes. Journal of Medical Entomology 35, 77–81.Google Scholar
KURTENBACH, K., DE MICHELIS, S., ETTI, S., SCHAFER, S. M., SEWELL, H. S., BRADE, V. & KRAICZY, P. ( 2002 a). Host association of Borrelia burgdorferi sensu lato – the key role of host complement. Trends in Microbiology 10, 74–79.Google Scholar
KURTENBACH, K., DE MICHELIS, S., SEWELL, H. S., ETTI, S., SCHAFER, S. M., HAILS, R., COLLARES-PEREIRA, M., SANTOS-REIS, M., HANINCOVA, K., LABUDA, M., BORMANE, A. & DONAGHY, M. ( 2001). Distinct combinations of Borrelia burgdorferi sensu lato genospecies found in individual questing ticks from Europe. Applied and Environmental Microbiology 67, 4926–4929.CrossRefGoogle Scholar
KURTENBACH, K., DIZIJ, A., SEITZ, H. M., MARGOS, G., MOTER, S. E., KRAMER, M. D., WALLICH, R., SCHAIBLE, U. E. & SIMON, M. M. ( 1994). Differential immune responses to Borrelia burgdorferi in European wild rodent species influence spirochete transmission to Ixodes ricinus L. (Acari: Ixodidae). Infection and Immunity 62, 5344–5352.Google Scholar
KURTENBACH, K., KAMPEN, H., DIZIJ, A., ARNDT, S., SEITZ, H. M., SCHAIBLE, U. E. & SIMON, M. M. ( 1995). Infestation of rodents with larval Ixodes ricinus (Acari: Ixodidae) is an important factor in the transmission cycle of Borrelia burgdorferi s.l. in German woodlands. Journal of Medical Entomology 32, 807–817.CrossRefGoogle Scholar
KURTENBACH, K., PEACEY, M., RIJPKEMA, S. G. T., HOODLESS, A. N., NUTTALL, P. A. & RANDOLPH, S. E. ( 1998 b). Differential transmission of the genospecies of Borrelia burgdorferi sensu lato by game birds and small rodents in England. Applied and Environmental Microbiology 64, 1169–1174.Google Scholar
KURTENBACH, K., SCHÄFER, S. M., SEWELL, H. S., PEACEY, M., HOODLESS, A., NUTTALL, P. A. & RANDOLPH, S. E. ( 2002 b). Differential survival of Lyme borreliosis spirochetes in ticks that feed on birds. Infection and Immunity 70, 5893–5895.Google Scholar
KURTENBACH, K., SEWELL, H. S., OGDEN, N. H., RANDOLPH, S. E. & NUTTALL, P. A. ( 1998 c). Serum complement sensitivity as a key factor in Lyme disease ecology. Infection and Immunity 66, 1248–1251.Google Scholar
LANE, R. S., CASHER, L. E., PEAVEY, C. A. & PIESMAN, J. ( 1998). Modified bait tube controls disease-carrying ticks and fleas. California Agriculture 52, 43–48.CrossRefGoogle Scholar
LANE, R. S. & LOYE, J. E. ( 1989). Lyme disease in California: interrelationship of Ixodes pacificus (Acari: Ixodidae), the western fence lizard (Sceloporus occidentalis), and Borrelia burgdorferi. Journal of Medical Entomology 26, 272–278.CrossRefGoogle Scholar
LATHROP, S. L., BALL, R., HABER, P., MOOTREY, G. T., BRAUN, M. M., SHADOMY, S. V., ELLENBERG, S. S., CHEN, R. T. & HAYES, E. B. ( 2002). Adverse events reports following vaccination for Lyme disease: December 1998–July 2000. Vaccine 20, 1603–1608.CrossRefGoogle Scholar
LEBET, N. & GERN, L. ( 1994). Histological examination of Borrelia burgdorferi infection in unfed Ixodes ricinus nymphs. Experimental and Applied Acarology 18, 177–183.CrossRefGoogle Scholar
LEES, A. D. & MILNE, A. ( 1951). The seasonal and diurnal activities of individual sheep ticks (Ixodes ricinus). Parasitology 41, 180–209.CrossRefGoogle Scholar
LE FLECHE, A., POSTIC, D., GIRARDET, K., PETER, O. & BARANTON, G. ( 1997). Characterization of Borrelia lusitaniae sp. nov. by 16S ribosomal DNA sequence analysis. International Journal Systematic Bacteriology 47, 921–925.Google Scholar
LEPRINCE, D. J. & LANE, R. S. ( 1996). Evaluation of permethrin-impregnated cotton balls as potential nesting material to control ectoparasites of woodrats in California. Journal of Medical Entomology 33, 355–360.CrossRefGoogle Scholar
LEUBA-GARCIA, S., KRAMER, M. D., WALLICH, R. & GERN, L. ( 1994). Characterization of Borrelia burgdorferi isolated from different organs of Ixodes ricinus ticks collected in nature. Zentralblatt für Bakteriologie 280, 468–475.CrossRefGoogle Scholar
LEUBA-GARCIA, S., MARTINEZ, R. & GERN, L. ( 1998). Expression of outer surface proteins A and C of Borrelia afzelii in Ixodes ricinus ticks and in the skin of mice. Zentralblatt für Bakteriologie und Hygiene 287, 475–484.CrossRefGoogle Scholar
LEVIN, M., LEVINE, J. F., YANG, S., HOWARD, P. & APPERSON, C. S. ( 1996). Reservoir competence of the southeastern five-line skink (Eumeces inexpectatus) and the green anole (Anolis carolinensis) for Borrelia burgdorferi. American Journal of Tropical Medicine and Hygiene 54, 92–97.CrossRefGoogle Scholar
LI, X. L., PEAVEY, C. A. & LANE, R. S. ( 2000). Density and spatial distribution of Ixodes pacificus (Acari: Ixodidae) in two recreational areas in north coastal California. American Journal of Tropical Medicine and Hygiene 62, 415–422.CrossRefGoogle Scholar
LIANG, F. T., STEERE, A. C., MARQUES, A. R., JOHNSON, B. J., MILLER, J. N. & PHILIPP, M. T. ( 1999). Sensitive and specific serodiagnosis of Lyme disease by enzyme-linked immunosorbent assay with a peptide based on an immunodominant conserved region of Borrelia burgdorferi vlsE. Journal of Clinical Microbiology 37, 3990–3996.Google Scholar
LIEBISCH, G., DIMPFL, B., FINKBEINER-WEBER, B., LIEBISCH, A. & FROSCH, M. ( 1998 a). The red fox (Vulpes vulpes) a reservoir competent host for Borrelia burgdorferi sensu lato. In 2nd International Conference on Tick-Borne Pathogens at the Host–Vector Interface: a Global Perspective, S.I.: The Conference ( ed. Coons, L. & Rothschild, M.), p. 238. Kruger National Park, South Africa.
LIEBISCH, G., FINKBEINER–WEBER, B. & LIEBISCH, A. ( 1996). The infection with Borrelia burgdorferi s.l. in the European hedgehog (Erinaceus europaeus) and its ticks. Parassitologia 38, 385.Google Scholar
LIEBISCH, G., SIHNS, B. & BAUTSCH, W. ( 1998 b). Detection and typing of Borrelia burgdorferi sensu lato in Ixodes ricinus ticks attached to human skin by PCR. Journal of Clinical Microbiology 36, 3355–3358.Google Scholar
LIN, T., OLIVER, J. H. Jr. & GAO, L. ( 2002). Genetic diversity of the outer surface protein C gene of southern Borrelia isolates and its possible epidemiological, clinical, and pathogenetic implications. Journal of Clinical Microbiology 40, 2572–2583.CrossRefGoogle Scholar
LINDSAY, L. R., BARKER, I. K., SURGEONER, G. A., McEWEN, S. A., GILLESPIE, T. J. & ROBINSON, J. T. ( 1995). Survival and development of Ixodes scapularis (Acari: Ixodidae) under various climatic conditions in Ontario, Canada. Journal of Medical Entomology 32, 143–152.CrossRefGoogle Scholar
LINDSAY, L. R., MATHISON, S. W., BARKER, I. K., McEWEN, S. A., GILLESPIE, T. J. & SURGEONER, G. A. ( 1999 a). Microclimate and habitat in relation to Ixodes scapularis (Acari: Ixodidae) populations on Long point, Ontario, Canada. Journal of Medical Entomology 36, 255–262.Google Scholar
LINDSAY, L. R., MATHISON, S. W., BARKER, I. K., McEWEN, S. A. & SURGEONER, G. A. ( 1999 b). Abundance of Ixodes scapularis (Acari: Ixodidae) larvae and nymphs in relation to host density and habitat on Long Point, Ontario. Journal of Medical Entomology 36, 243–254.Google Scholar
LIVERIS, D., WANG, G., GIRAO, G., BYRNE, D. W., NOWAKOWSKI, J., McKENNA, D., NADELMAN, R., WORMSER, G. P. & SCHWARTZ, I. ( 2002). Quantitative detection of Borrelia burgdorferi in 2-millimeter skin samples of erythema migrans lesions: correlation of results with clinical laboratory findings. Journal of Clinical Microbiology 40, 1249–1253.CrossRefGoogle Scholar
LOGIGIAN, E. L., KAPLAN, R. F. & STEERE, A. C. ( 1990). Chronic neurologic manifestations of Lyme disease. New England Journal of Medicine 323, 1438–1444.CrossRefGoogle Scholar
MAGID, D., SCHWARTZ, B., CRAFT, J. & SCHWARTZ, J. S. ( 1992). Prevention of Lyme disease after tick bites: A cost effectiveness analysis. New England Journal of Medicine 327, 534–541.CrossRefGoogle Scholar
MAIN, A. J., SPRANCE, H. E., KLOTER, K. O. & BROWN, S. E. ( 1981). Ixodes dammini (Acari: Ixodidae) on white-tailed deer (Odocoileus virginianus) in Connecticut. Journal of Medical Entomology 18, 487–492.CrossRefGoogle Scholar
MANWEILER, S. A., LANE, R. S., BLOCK, W. M. & MORRISON, M. L. ( 1990). Survey of birds and lizards for ixodid ticks (Acari) and spirochetal infection in northern California. Journal of Medical Entomology 27, 1011–1015.CrossRefGoogle Scholar
MARCONI, R. T., LIVERIS, D. & SCHWARTZ, I. ( 1995). Identification of novel insertion elements, restriction fragment length polymorphism patterns, and discontinuous 23S rRNA in Lyme disease spirochetes: phylogenetic analyses of rRNA genes and their intergenic spacers in Borrelia japonica sp. nov. and genomic group 21038 (Borrelia andersonii sp. nov.) isolates. Journal of Clinical Microbiology 33, 2427–2434.Google Scholar
MATHER, T. N., RIBEIRO, J. M. & SPIELMAN, A. ( 1987). Lyme disease and babesiosis: acaricide focused on potentially infected ticks. American Journal of Tropical Medicine and Hygiene 36, 609–614.CrossRefGoogle Scholar
MATHER, T. N., TELFORD, S. R. III, MacLACHLAN, A. B. & SPIELMAN, A. ( 1989 a). Incompetence of catbirds as reservoirs for the Lyme disease spirochete (Borrelia burgdorferi). Journal of Parasitology 75, 66–69.Google Scholar
MATHER, T. N., WILSON, M. L., MOORE, S. I., RIBEIRO, J. M. & SPIELMAN, A. ( 1989 b). Comparing the relative potential of rodents as reservoirs of the lyme disease spirochete (Borrelia burgdorferi). American Journal of Epidemiology 130, 143–150.Google Scholar
MATHIESEN, D. A., OLIVER, J. H. Jr., KOLBERT, C. P., TULLSON, E. D., JOHNSON, B. J. B., CAMPBELL, G. L., MITCHELL, P. D., REED, K. D., TELFORD, S. R. III, ANDERSON, J. F., LANE, R. S. & PERSING, D. H. ( 1997). Genetic heterogeneity of Borrelia burgdorferi in the United States. Journal of Infectious Diseases 175, 98–107.CrossRefGoogle Scholar
MATUSCHKA, F. R., ALLGÖWER, R., SPIELMAN, A. & RICHTER, D. ( 1999). Characteristics of garden dormice that contribute to their capacity as reservoirs for Lyme disease spirochetes. Applied and Environmental Microbiology 65, 707–711.Google Scholar
MATUSCHKA, F. R., EIFFERT, H., OHLENBUSCH, A., RICHTER, D., SCHEIN, E. & SPIELMAN, A. ( 1994 a). Transmission of the agent of Lyme disease on a subtropical island. Tropical Medicine and Parasitology 45, 39–44.Google Scholar
MATUSCHKA, F. R., EIFFERT, H., OHLENBUSCH, A. & SPIELMAN, A. ( 1994 b). Amplifying role of edible dormice in Lyme disease transmission in Central Europe. Journal of Infectious Diseases 170, 122–127.Google Scholar
MATUSCHKA, F. R., ENDEPOLS, S., RICHTER, D., OHLENBUSCH, A., EIFFERT, H. & SPIELMAN, A. ( 1996). Risk of urban Lyme disease enhanced by the presence of rats. Journal of Infectious Diseases 174, 1108–1111.CrossRefGoogle Scholar
MATUSCHKA, F. R., ENDEPOLS, S., RICHTER, D. & SPIELMAN, A. ( 1997). Competence of urban rats as reservoir hosts for Lyme disease spirochetes. Journal of Medical Entomology 34, 489–493.CrossRefGoogle Scholar
MATUSCHKA, F. R., FISCHER, P., HEILER, M., RICHTER, D. & SPIELMAN, A. ( 1992). Capacity of European animals as reservoir hosts for the Lyme disease spirochete. Journal of Infectious Diseases 165, 479–483.CrossRefGoogle Scholar
MATUSCHKA, F. R., SCHINKEL, T. W., KLUG, B., SPIELMAN, A. & RICHTER, D. ( 2000). Relative incompetence of European rabbits for Lyme disease spirochaetes. Parasitology 121, 297–302.CrossRefGoogle Scholar
MAUPIN, G. O., FISH, D., ZULTOWSKY, J., CAMPOS, E. G. & PIESMAN, J. ( 1991). Landscape ecology of Lyme disease in a residential area of Westchester County, New York. American Journal of Epidemiology 133, 1105–1113.CrossRefGoogle Scholar
McCOY, K. D., BOULINIER, T., CHARDINE, J. W., DANCHIN, E. & MICHALAKIS, Y. ( 1999). Dispersal and distribution of the tick Ixodes uriae within and among seabird populations: the need for a population genetic approach. Journal of Parasitology 85, 196–202.CrossRefGoogle Scholar
McLEAN, R. G., UBICO, S. R., HUGHES, C. A., ENGSTROM, S. M. & JOHNSON, R. C. ( 1993). Isolation and characterization of Borrelia burgdorferi from blood of a bird captured in the Saint Croix River Valley. Journal of Clinical Microbiology 31, 2038–2043.Google Scholar
McLEOD, J. ( 1935). Ixodes ricinus in relation to its physical environment. IV. An analysis of the ecological complexes controlling distribution and activities. Parasitology 28, 295–319.Google Scholar
MEJLON, H. A. & JAENSON, T. G. T. ( 1997). Questing behaviour of Ixodes ricinus ticks (Acari: Ixodidae). Experimental and Applied Acarology 21, 747–754.CrossRefGoogle Scholar
MEJLON, H., JAENSON, T. G. T. & MATHER, T. N. ( 1995). Evaluation of host-targeted applications of permethrin for control of Borrelia-infected Ixodes ricinus (Acari: Ixodidae). Medical and Veterinary Entomology 9, 207–210.CrossRefGoogle Scholar
MELKERT, P. W. & STEL, H. V. ( 1991). Neonatal Borrelia infections (relapsing fever): report of 5 cases and review of the literature. East Afrcian Medical Journal 68, 999–1005.Google Scholar
MISONNE, M. C., VAN IMPE, G. & HOET, P. P. ( 1998). Genetic heterogeneity of Borrelia burgdorferi sensu lato in Ixodes ricinus ticks collected in Belgium. Journal of Clinical Microbiology 36, 3352–3354.Google Scholar
MIYAMOTO, K. & MASUZAWA, T. ( 2002). Ecology of Borrelia burgdorferi sensu lato in Japan and East Asia. In Lyme Borreliosis: Biology, Epidemiology and Control ( ed. Gray, J., Kahl, O., Lane, R. S. & Stanek, G.), pp. 201–222. CABI International, Wallingford, Oxford, UK.CrossRef
MIZAK, B. & KROL, J. ( 2000). Analysis of polish isolates of Borrelia burgdorferi by amplification of (5S)-rrl (23S) intergenic spacer. Bulletin of the Veterinary Institute in Pulawy 44, 147–154.Google Scholar
MOREL, P. C. ( 1965). Les tiques d'Afrique et du bassin méditerranéen. Maison Alfort (I.E.M.T.Y.). Document polycopié: pp. 695.
NADELMAN, R. B., NOWAKOWSKI, J., FISH, D., FALCO, R. C., FREEMAN, K., McKENNA, D., WELCH, P., MARCUS, R., AGUERO-ROSENFELD, M. E., DENNIS, D. T. & WORMSER, G. P. ( 2001). Prophylaxis with the single-dose doxycycline for the prevention of Lyme disease after an Ixodes scapularis tick bite. New England Journal of Medicine 345, 79–84.CrossRefGoogle Scholar
NADELMAN, R. B. & WORMSER, G. P. ( 2002). Recognition and treatment of erythema migrans: Are we off target? Annals of Internal Medicine 136, 477–479.Google Scholar
NELSON, D. R., ROONEY, S., MILLER, N. J. & MATHER, T. R. ( 2000). Complement-mediated killing of Borrelia burgdorferi by nonimmune sera from sika deer. Journal of Parasitology 86, 1232–1238.CrossRefGoogle Scholar
NOCTON, J. J., DRESSLER, F., RUTLEDGE, B. J., RYS, P. N., PERSING, D. H. & STEERE, A. C. ( 1994). Detection of Borrelia burgdorferi DNA by polymerase chain reaction in synovial fluid from patients with Lyme arthritis. New England Journal of Medicine 330, 229–234.CrossRefGoogle Scholar
NORRIS, D. E., JOHNSON, B. J. B., PIESMAN, J., MAUPIN, G. O., CLARK, J. L. & BLACK, W. C. IV ( 1999). Population genetics and phylogenetic analysis of Colorado Borrelia burgdorferi. American Journal of Tropical Medicine and Hygiene 60, 699–707.CrossRefGoogle Scholar
NORRIS, D. E., KLOMPEN, J. S. H., KEIRANS, J. E., LANE, R. S., PIESMAN, J. & BLACK, W. C. IV ( 1996). Population genetics of Ixodes scapularis (Acari: Ixodidae) based on mitochondrial 16S and 12S genes. Journal of Medical Entomology 33, 78–89.CrossRefGoogle Scholar
NOWAKOWSKI, J., SCHWARTZ, I., LIVERIS, D., WANG, G., AGUERO-ROSENFELD, M. E., GIRAO, G., McKENNA, D., NADELMAN, R. B., CAVALIERE, L. F. & WORMSER, G. P. ( 2001). Laboratory diagnostic techniques for patients with early Lyme disease associated with erythema migrans: a comparison of different techniques. Clinical Infectious Diseases 33, 2023–2037.CrossRefGoogle Scholar
NUNCIO, M. S., PETER, O., ALVES, M. J., BACELLAR, F. & FILIPE, A. R. ( 1993). Isolamento e caracterizaçao de borrélias de Ixodes ricinus L. em Portugal. Revista Portuguesa Doenças Infecciosas 16, 175–179.Google Scholar
OGDEN, N. H., NUTTALL, P. A. & RANDOLPH, S. E. ( 1997). Natural Lyme disease cycles maintained via sheep by co-feeding ticks. Parasitology 115, 591–599.CrossRefGoogle Scholar
OHNISHI, J., PIESMAN, J. & De SILVA, A. M. ( 2001). Antigenic and genetic heterogeneity of Borrelia burgdorferi populations transmitted by ticks. Proceedings of the National Academy of Sciences, USA 98, 670–675.CrossRefGoogle Scholar
OLIVER, J. H. Jr., CUMMINS, G. A. & JOINER, M. S. ( 1993 a). Immature Ixodes scapularis (Acari: Ixodidae) parasitizing lizards from the southeastern USA. Journal of Parasitology 79, 684–689.Google Scholar
OLIVER, J. H. Jr., OWSLEY, M. R., HUTCHESON, H. J., JAMES, A. M., CHEN, C., IRBY, W. S., DOTSON, E. M. & McLAIN, D. K. ( 1993 b). Conspecificity of the ticks Ixodes scapularis and I. dammini (Acari: Ixodidae). Journal of Medical Entomology 30, 54–63.Google Scholar
OLSEN, B. ( 1995). Birds and Borrelia. PhD thesis, pp. 81. Umeå University, Umeå, Sweden.
OLSEN, B., DUFFY, D. C., JAENSON, T. G. T., GYLFE, Å., BONNEDAHL, J. & BERGSTRÖM, S. ( 1995 a). Transhemispheric exchange of Lyme disease spirochetes by seabirds. Journal of Clinical Microbiology 33, 3270–3274.Google Scholar
OLSEN, B., JAENSON, T. G. T., NOPPA, L., BUNIKIS, J. & BERGSTRÖM, S. ( 1993). A Lyme borreliosis cycle in seabirds and Ixodes uriae ticks. Nature 362, 340–342.CrossRefGoogle Scholar
OLSEN, B., JAENSON, T. G. T. & BERGSTRÖM, S. ( 1995 b). Prevalence of Borrelia burgdorferi sensu lato-infected ticks on migrating birds. Applied and Environmental Microbiology 61, 3082–3087.Google Scholar
OLSON, C. A., CUPP, E. W., LUCKHART, S., RIBEIRO, J. M. C. & LEVY, C. ( 1992). Occurrence of Ixodes pacificus (Parasitoformes: Ixodidae) in Arizona. Journal of Medical Entomology 29, 1060–1062.CrossRefGoogle Scholar
PAL, U., DE SILVA, A. M., MONTGOMERY, R. R., FISH, D., ANGUITA, J., ANDERSON, J. F., LOBET, Y. & FIKRIG, E. ( 2000). Attachment of Borrelia burgdorferi within Ixodes scapularis mediated by outer surface protein A. Journal of Clinical Investigation 106, 561–569.CrossRefGoogle Scholar
PEAVEY, C. A. & LANE, R. S. ( 1995). Transmission of Borrelia burgdorferi by Ixodes pacificus nymphs and reservoir competence of deer mice (Peromyscus maniculatus) infected by tick-bite. Journal of Parasitology 81, 175–178.CrossRefGoogle Scholar
PEAVEY, C. A., LANE, R. S. & KLEINJAN, J. E. ( 1997). Role of small mammals in the ecology of Borrelia burgdorferi in a peri-urban park in north coastal California. Experimental and Applied Acarology 21, 569–584.CrossRefGoogle Scholar
PERRET, J. L., GUIGOZ, E., RAIS, O. & GERN, L. ( 2000). Influence of saturation deficit and temperature on Ixodes ricinus tick questing activity in a Lyme borreliosis-endemic area (Switzerland). Parasitology Research 86, 554–557.CrossRefGoogle Scholar
PETER, O. & BRETZ, A. G. ( 1992). Polymorphism of outer surface proteins of Borrelia burgdorferi as a tool for the classification. Zentralblatt für Bakteriologie 277, 28–33.CrossRefGoogle Scholar
PETER, O., BRETZ, A. G. & BEE, D. ( 1995). Occurrence of different genospecies of Borrelia burgdorferi sensu lato in Ixodid ticks of Valais, Switzerland. European Journal of Epidemiology 11, 463–467.CrossRefGoogle Scholar
PHILIPP, M. T., BOWERS, L. C., FAWCETT, P. T., JACOBS, M. B., LIANG, F. T., MARQUES, A. R., MITCHELL, P. D., PURCELL, J. E., RATTERREE, M. S. & STAUBINGER, R. K. ( 2001). Antibody response to IR6, a conserved immunodominant region of the vlsE lipoprotein, wanes rapidly after antibiotic treatment of Borrelia burgdorferi infection in experimental animals and in humans. Journal of Infectious Diseases 184, 870–878.CrossRefGoogle Scholar
PHILLIPS, C. B., LIANG, M. H., SANGHA, O., WRIGHT, E. A., FOSSEL, A. H., LEW, R. A., FOSSEL, K. K. & SHADICK, N. A. ( 2001). Lyme disease and preventive behaviors in residents of Nantucket Island, Massachusetts. American Journal of Preventive Medicine 20, 219–224.CrossRefGoogle Scholar
PICHON, B., GODFROID, E., HOYOIS, B., BOLLEN, A., RODHAIN, F. & PEREZ, C. ( 1995). Simultaneous infection of Ixodes ricinus by two Borrelia burgdorferi sensu lato species: possible implications for clinical manifestations. Emerging Infectious Diseases 1, 89–90.CrossRefGoogle Scholar
PICKEN, R. N., CHENG, Y., STRLE, F. & PICKEN, M. M. ( 1996). Patient isolates of Borrelia burgdorferi sensu lato with genotypic and phenotypic similarities to strain 25015. Journal of Infectious Diseases 174, 1112–1115.CrossRefGoogle Scholar
PICKEN, R. N. & PICKEN, M. M. ( 2000). Molecular characterization of Borrelia spp. isolates from greater metropolitan Chicago reveals the presence of Borrelia bissettii. Preliminary report. Journal of Molecular Microbiology and Biotechnology 2, 505–507.Google Scholar
PICKEN, R. N., STRLE, F., PICKEN, M. M., RUZIC-SABLJIC, E., MARASPIN, V., LOTRIC-FURLAN, S. & CIMPERMAN, J. ( 1998). Identification of three species of Borrelia burgdorferi sensu lato (B. burgdorferi sensu stricto, B. garinii, and B. afzelii) among isolates from acrodermatitis chronica atrophicans lesions. Journal of Investigative Dermatology 110, 211–214.Google Scholar
PIESMAN, J. ( 1989). Transmission of Lyme disease spirochetes (Borrelia burgdorferi). Experimental and Applied Acarology 7, 71–80.CrossRefGoogle Scholar
PIESMAN, J., MATHER, T. N., DAMMIN, G. J., TELFORD, S. R., LASTIVICA, C. C. & SPIELMAN, A. ( 1987 a). Seasonal variation of transmission risk: Lyme disease and human babesiosis. American Journal of Epidemiology 126, 1187–1189.Google Scholar
PIESMAN, J., MATHER, T. N., SINSKY, R. J. & SPIELMAN, A. ( 1987 b). Duration of tick attachment and Borrelia burgdorferi transmission. Journal of Clinical Microbiology 25, 557–558.Google Scholar
PIESMAN, J., MAUPIN, G. O., CAMPOS, E. G. & HAPP, C. M. ( 1991). Duration of adult female Ixodes dammini attachment and transmission of Borrelia burgdorferi, with description of a needle aspiration isolation method. Journal of Infectious Diseases 163, 895–897.CrossRefGoogle Scholar
PIESMAN, J., SCHNEIDER, B. S. & ZEIDNER, N. S. ( 2001). Use of quantitative PCR to measure the density of Borrelia burgdorferi in the midgut and salivary glands of feeding tick vectors. Journal of Clinical Microbiology 39, 4145–4148.CrossRefGoogle Scholar
PIESMAN, J. & SPIELMAN, A. ( 1979). Host-associations and seasonal abundance of immature Ixodes dammini in southeastern Massachusetts. Annals of the Entomological Society of America 72, 829–832.CrossRefGoogle Scholar
PIESMAN, J., SPIELMAN, A., ETKIND, P., RUEBUSH, T. K. II & JURANEK, D. D. ( 1979). Role of deer in the epizootiology of Babesia microti in Massachusetts, USA. Journal of Medical Entomology 15, 437–440.Google Scholar
PORCELLA, S. F., RAFFEL, S. J., SCHRUMPF, M. E., SCHRIEFER, M. E., DENNIS, D. T. & SCHWAN, T. G. ( 2000). Serodiagnosis of louse-borne relapsing fever with glycerophosphodiester phosphodiesterase (GlpQ) from Borrelia recurrentis. Journal of Clinical Microbiology 38, 3561–3571.Google Scholar
POSTIC, D., ASSOUS, M. V., GRIMONT, P. A. & BARANTON, G. ( 1994). Diversity of Borrelia burgdorferi sensu lato evidenced by restriction fragment length polymorphism of rrf (5S)-rrl (23S) intergenic spacer amplicons. International Journal of Systematic Bacteriology 44, 743–752.CrossRefGoogle Scholar
POSTIC, D., KORENBERG, E., GORELOVA, N., KOVALEVSKI, Y. V., BELLENGER, E. & BARANTON, G. ( 1997). Borrelia burgdorferi sensu lato in Russia and neighbouring countries: high incidence of mixed isolates. Research in Microbiology 148, 691–702.CrossRefGoogle Scholar
POSTIC, D., RAS, N. M., LANE, R. S., HENDSON, M. & BARANTON, G. ( 1998). Expanded diversity among California borrelia isolates and description of Borrelia bissettii sp. nov. (formerly Borrelia group DN127). Journal of Clinical Microbiology 36, 3497–3504.Google Scholar
POUND, J. M., MILLER, J. A. & GEORGE, J. E. ( 2000). Efficacy of amitraz applied to white-tailed deer by the ‘4-poster’ topical treatment device in controlling free-living lone star ticks (Acari: Ixodidae). Journal of Medical Entomology 37, 878–884.CrossRefGoogle Scholar
QIU, W. G., DYKHUIZEN, D. E., ACOSTA, M. A. & LUFT, B. J. ( 2002). Geographic uniformity of the Lyme disease spirochete (Borrelia burgdorferi) and its shared history with tick vector (Ixodes scapularis) in the northeastern United States. Genetics 160, 833–849.Google Scholar
RANDOLPH, S. E. & CRAINE, N. G. ( 1995). General framework for comparative quantitative studies on transmission of tick-borne diseases using Lyme borreliosis in Europe as an example. Journal of Medical Entomology 32, 765–777.CrossRefGoogle Scholar
RANDOLPH, S. E., GERN, L. & NUTTALL, P. A. ( 1996). Co-feeding ticks: epidemiological significance for tick-borne pathogen transmission. Parasitology Today 12, 472–479.CrossRefGoogle Scholar
RANDOLPH, S. E., GREEN, R. M., HOODLESS, A. N. & PEACEY, M. F. ( 2002). An empirical quantitative framework for the seasonal population dynamics of the tick Ixodes ricinus. International Journal for Parasitology 32, 979–989.CrossRefGoogle Scholar
RANDOLPH, S. E., GREEN, R. M., PEACEY, M. F. & ROGERS, D. J. ( 2000). Seasonal synchrony: the key to tick-borne encephalitis foci identified by satellite data. Parasitology 121, 15–23.CrossRefGoogle Scholar
RANDOLPH, S. & STOREY, K. ( 1999). Impact of microclimate on immature tick-rodent host interactions (Acari: Ixodidae): implications for parasite transmission. Journal of Medical Entomology 36, 741–748.CrossRefGoogle Scholar
REIK, L., STEERE, A. C., BARTENHAGEN, N. H., SHOPE, R. E. & MALAWISTA, S. E. ( 1979). Neurologic abnormalities of Lyme disease. Medicine (Baltimore) 58, 281–294.CrossRefGoogle Scholar
RICH, S. M., ARMSTRONG, P. M., SMITH, R. D. & TELFORD, S. R. III ( 2001). Lone star tick-infecting borreliae are most closely related to the agent of bovine borreliosis. Journal of Clinical Microbiology 39, 494–497.CrossRefGoogle Scholar
RICH, S. M., CAPORALE, D. A., TELFORD, S. R., KOCHER, T. D., HARTL, D. L. & SPIELMAN, A. ( 1995). Distribution of the Ixodes ricinus-like ticks of eastern North America. Proceedings of the National Academy of Sciences, USA 92, 6284–6288.CrossRefGoogle Scholar
RICHTER, D., ENDEPOLS, S., OHLENBUSCH, A., EIFFERT, H., SPIELMAN, A. & MATUSCHKA, F. R. ( 1999). Genospecies diversity of Lyme disease spirochetes in rodent reservoirs. Emerging Infectious Diseases 5, 291–296.CrossRefGoogle Scholar
RICHTER, D., SCHLEE, D. B. & MATUSCHKA, F. R. ( 2003). Relapsing fever-like spirochetes infecting European vector tick of Lyme disease agent. Emerging Infectious Diseases 9, 697–701.CrossRefGoogle Scholar
RICHTER, D., SPIELMAN, A., KOMAR, N. & MATUSCHKA, F. R. ( 2000). Competence of American Robins as reservoir hosts for Lyme disease spirochetes. Emerging Infectious Diseases 6, 133–138.CrossRefGoogle Scholar
RIJPKEMA, S. G. T., GOLUBIC, D., MOLKENBOER, M., VERBEEEK-DE KRUIF, N. & SCHELLENKENS, J. F. P. ( 1996). Identification of four genomic groups of Borrelia burgdorferi sensu lato in Ixodes ricinus ticks collected in a Lyme borreliosis endemic region of northern Croatia. Experimental and Applied Acarology 20, 23–30.Google Scholar
RIJPKEMA, S. G. T., MOLKENBOER, M. J. C. H., SCHOULS, L. M., JONGEJAN, F. & SCHELLENKENS, J. F. P. ( 1995). Simultaneous detection and genotyping of three genomic groups of Borrelia burgdorferi sensu lato in Dutch Ixodes ricinus ticks by characterization of the amplified intergenic spacer region between 5S and 23S rRNA genes. Journal of Clinical Microbiology 33, 3091–3095.Google Scholar
ROBERTSON, J., GUY, E., ANDREWS, N., WILSKE, B., ANDA, P., GRANSTROM, M., HAUSER, U., MOOSMANN, Y., SAMBRI, V., SCHELLEKENS, J., STANEK, G. & GRAY, J. ( 2000). A European multicenter study of immunoblotting in serodiagnosis of Lyme borreliosis. Journal of Clinical Microbiology 38, 2097–2102.Google Scholar
ROTHERMEL, H., HEDGES, T. R. 3rd & STEERE, A. C. ( 2001). Optic neuropathy in children with Lyme disease. Pediatrics 108, 477–481.CrossRefGoogle Scholar
SARIH, M., JOUDA, F., GERN, L. & POSTIC, D. ( 2003). First isolation of Borrelia burgdorferi sensu lato from Ixodes ricinus ticks in Morocco. Zoonosis and Vector-Borne Diseases 3, 133–139.CrossRefGoogle Scholar
SCHNEIDER, B. S., ZEIDNER, N. S., BURKOT, T. R., MAUPIN, G. O. & PIESMAN, J. ( 2000). Borrelia isolates in northern Colorado identified as Borrelia bissettii. Journal of Clinical Microbiology 38, 3103–3105.Google Scholar
SCHOULS, L. M., Van De POL, I., RIJPKEMA, S. G. T. & SCHOT, C. S. ( 1999). Detection and identification of Ehrlichia, Borrelia burgdorferi sensu lato, and Bartonella species in Dutch Ixodes ricinus ticks. Journal of Clinical Microbiology 37, 2215–2222.Google Scholar
SCHULZE, T. L., JORDAN, R. A. & HUNG, R. W. ( 1995). Suppresion of subadult Ixodes scapularis (Acari: Ixodidae) following removal of leaf litter. Journal of Medical Entomology 32, 730–733.CrossRefGoogle Scholar
SCHULZE, T. L., JORDAN, R. A. & HUNG, R. W. ( 1998). Comparison of Ixodes scapularis (Acari: Ixodidae) populations and their habitats in established and emerging Lyme disease areas in New Jersey. Journal of Medical Entomology 35, 64–70.CrossRefGoogle Scholar
SCHULZE, T. L., JORDAN, R. A., HUNG, R. W., TAYLOR, R. C., MARKOWSKI, D. & CHOMSKY, M. S. ( 2001). Efficacy of granular deltamethrin against Ixodes scapularis and Amblyomma americanum (Acari: Ixodidae) nymphs. Journal of Medical Entomology 38, 344–346.CrossRefGoogle Scholar
SCHULZE, T. L., JORDAN, R. A., VASVARY, L. M., CHOMSKY, M. S., SHAW, D. C., MEDDIS, M. A., TAYLOR, R. C. & PIESMAN, J. ( 1994). Suppression of Ixodes dammini (Acari: Ixodidae) nymphs in a large residential community. Journal of Medical Entomology 31, 206–211.CrossRefGoogle Scholar
SCHWAN, T. G. & PIESMAN, J. ( 2002). Vector interactions and molecular adaptations of Lyme disease and relapsing fever spirochetes associated with transmission by ticks (Perspectives). Emerging Infectious Diseases 8, 115–121.CrossRefGoogle Scholar
SCHWARTZ, I., WORMSER, G. P., SCHWARTZ, J. J., COOPER, D., WEISSENSEE, P., GAZUMYAN, A., ZIMMERMAN, E., GOLDBERG, N. S., BITTKER, S. & CAMPBELL, G. L. ( 1992). Diagnosis of early Lyme disease by polymerase chain reaction amplification and culture of skin biopsies from erythema migrans lesions. Journal of Clinical Microbiology 30, 3082–3088.Google Scholar
SCOLES, G. A., PAPERO, M., BEATI, L. & FISH, D. ( 2001). A relapsing fever group spirochete transmitted by Ixodes scapularis ticks. Vector Borne and Zoonotic Diseases 1, 21–34.CrossRefGoogle Scholar
SEINOST, G., DYKHUIZEN, D. E., DATTWYLER, R. J., GOLDE, W. T., DUNN, J. J., WANG, I. N., WORMSER, G. P., SCHRIEFER, M. E. & LUFT, B. J. ( 1999). Four clones of Borrelia burgdorferi sensu stricto cause invasive infection in humans. Infection and Immunity 67, 3518–3524.Google Scholar
SIGAL, L. H., ZAHRADNIK, J. M., LAVIN, P., PATELLA, S. J., BRYANT, G., HASELBY, R., HILTON, E., KUNKEL, M., ADLER-KLEIN, D., DOHERTY, T., EVANS, J., MOLLOY, P. J., SEIDNER, A. L., SABETTA, J. R., SIMON, H. J., KLEMPNER, M. S., MAYS, J., MARKS, D. & MALAWISTA, S. E. ( 1998). A vaccine consisting of recombinant Borrelia burgdorferi outer-surface protein A to prevent Lyme disease. Recombinant Outer-Surface Protein A Lyme Disease Vaccine Study Consortium. New England Journal of Medicine 339, 216–222.Google Scholar
SLAJCHERT, T., KITRON, U. D., JONES, C. J. & MANNELLI, A. ( 1997). Role of the eastern chipmunk (Tamias striatus) in the epizootiology of Lyme borreliosis in northwestern Illinois, USA. Journal of Wildlife Diseases 33, 40–46.CrossRefGoogle Scholar
SMITH, R. P. Jr., RAND, P. W., LACOMBE, E. H., TELFORD, S. R. III, RICH, S. M., PIESMAN, J. & SPIELMAN, A. ( 1993). Norway rats as reservoir hosts for Lyme disease spirochetes on Monhegan Island, Maine. Journal of Infectious Diseases 168, 687–691.CrossRefGoogle Scholar
SMITH, R. P., SCHOEN, R. T., RAHN, D. W., SIKAND, V. K., NOWAKOWSKI, J., PARENTI, D. L., HOLMAN, M., PERSING, D. H. & STEERE, A. C. ( 2002). Clinical characteristics and treatment outcome of early Lyme disease in patients with microbiologically confirmed erythema migrans. Annals of Internal Medicine 136, 421–428.CrossRefGoogle Scholar
SONENSHINE, D. E. & HAINES, G. ( 1985). A convenient method for controlling populations of the American dog tick, Dermacentor variabilis (Acari: Ixodidae), in the natural environment. Journal of Medical Entomology 22, 577–583.CrossRefGoogle Scholar
SOOD, S. K., SALZMAN, M. B., JOHNSON, B. J. B., HAPP, C. M., FEIG, K., CARMODY, L., RUBIN, L. G., HILTON, E. & PIESMAN, J. ( 1997). Duration of tick attachment as a predictor of the risk of Lyme disease in an area in which Lyme disease is endemic. Journal of Infectious Diseases 175, 996–999.CrossRefGoogle Scholar
SPIELMAN, A. ( 1988). Lyme disease and human babesiosis: evidence incriminating vector and reservoir hosts. In Biology of Parasitism ( ed. Englund, P. T. & Sher, A.), pp. 147–165. A.R. Liss, New York.
SPIELMAN, A., CLIFFORD, C. M., PIESMAN, J. & CORWIN, M. D. ( 1979). Human babesiosis on Nantucket Island: description of the vector, Ixodes (Ixodes) dammini, n. sp. (Acarina: Ixodidae). Journal of Medical Entomology 15, 218–234.Google Scholar
SPIELMAN, A., LEVINE, J. F. & WILSON, M. L. ( 1984). Vectorial capacity of North American Ixodes ticks. Yale Journal of Biology and Medicine 57, 507–513.Google Scholar
SPIELMAN, A., WILSON, M. L., LEVINE, J. L. & PIESMAN, J. ( 1985). Ecology of Ixodes dammini-borne human babesiosis and Lyme disease. Annual Review of Entomology 30, 439–460.CrossRefGoogle Scholar
STAFFORD, K. C. III ( 1991 a). Effectiveness of carbaryl applications for the control of Ixodes dammini (Acari: Ixodidae) nymphs in an endemic residential area. Journal of Medical Entomology 28, 32–36.Google Scholar
STAFFORD, K. C. III ( 1991 b). Effectiveness of host-targeted permethrin in the control of Ixodes dammini (Acari: Ixodidae). Journal of Medical Entomology 28, 611–617.Google Scholar
STAFFORD, K. C. III ( 1992). Third year evaluation of host-targeted permethrin for the control of Ixodes dammini (Acari: Ixodidae) in southeastern Connecticut. Journal of Medical Entomology 29, 717–720.CrossRefGoogle Scholar
STAFFORD, K. C. III ( 1993). Reduced abundance of Ixodes scapularis (Acari: Ixodidae) with exclusion of deer by electric fencing. Journal of Medical Entomology 30, 986–996.CrossRefGoogle Scholar
STAFFORD, K. C. III ( 1994). Survival of immature Ixodes scapularis (Acari: Ixodidae) at different relative humidities. Journal of Medical Entomology 31, 310–314.CrossRefGoogle Scholar
STAFFORD, K. C. III ( 1997). Pesticide use by licensed applicators for the control of Ixodes scapularis (Acari: Ixodidae) in Connecticut. Journal of Medical Entomology 34, 552–558.CrossRefGoogle Scholar
STAFFORD, K. C. III, BLADEN, V. C. & MAGNARELLI, L. A. ( 1995). Ticks (Acari: Ixodidae) infesting wild birds (Aves) and white-footed mice in Lyme, CT. Journal of Medical Entomology 32, 453–466.CrossRefGoogle Scholar
STAFFORD, K. C. III, DENICOLA, A. J. & MAGNARELLI, L. A. ( 1996). Presence of Ixodiphagus hookeri (Hymenoptera: Encyrtidae) in two populations of Ixodes scapularis (Acari: Ixodidae). Journal of Medical Entomology 33, 183–188.CrossRefGoogle Scholar
STAFFORD, K. C. III, WARD, J. S. & MAGNARELLI, L. A. ( 1998). Impact of controlled burns on the abundance of Ixodes scapularis (Acari: Ixodidae). Journal of Medical Entomology 35, 510–513.CrossRefGoogle Scholar
STANCZAK, J., KUBICA-BIERNAT, B., RACEWICZ, M., KRUMINIS-LOZOWSKA, W. & KUR, J. ( 2000). Detection of three genospecies of Borrelia burgdorferi sensu lato in Ixodes ricinus ticks collected in different regions of Poland. International Journal of Microbiology 290, 559–566.CrossRefGoogle Scholar
STANEK, G. & KAHL, O. ( 1999). Chemoprophylaxis for Lyme Borreliosis? Zentralblatt für Bakteriologie 289, 655–695.Google Scholar
STANEK, G., O'CONNELL, S., CIMMINO, M., ABERER, E., KRISTOFERITSCH, W., GRANSTROM, M., GUY, E. & GRAY, J. ( 1996). European Union concerted action on risk assessment in Lyme borreliosis: clinical case definitions for Lyme borreliosis. Wiener Klinische Wochenschrift 108, 741–747.Google Scholar
STANEK, G., STRLE, J., GRAY, J. & WORMSER, G. P. ( 2002). History and characteristics of Lyme Borreliosis. In Lyme Borreliosis: Biology, Epidemiology and Control ( ed. Gray, J., Kahl, O., Lane, R. S. & Stanek, G.), pp. 1–28. CABI International, Wallingford, Oxford, UK.CrossRef
STEELE, G. M. & RANDOLPH, S. E. ( 1985). An experimental evaluation of conventional control measures against the sheep tick, Ixodes ricinus (L.) (Acari: Ixodidae). I. A unimodal seasonal activity pattern. Bulletin of Entomological Research 75, 489–499.Google Scholar
STEERE, A. C. ( 1989). Lyme disease. New England Journal of Medicine 308, 586–596.CrossRefGoogle Scholar
STEERE, A. C. ( 1994). Lyme borreliosis. In Thirteenth Edition Harrison's Principles of Internal Medicine. Vol. 1 ( ed. Isselbacher, I., Braunwald, E., Wilson, J. D., Martin, J. B., Fauci, A. S. & Kasper, D. L.), pp. 745–747. McGraw-Hill, New York.
STEERE, A. C. ( 2001). Lyme disease. New England Journal of Medicine 345, 115–125.CrossRefGoogle Scholar
STEERE, A. C., BATSFORD, W. P., WEINBERG, M., ALEXANDER, J., BERGER, H. J., WOLFSON, S. & MALAWISTA, S. E. ( 1980). Lyme carditis: cardiac abnormalities of Lyme disease. Annals of Internal Medicine 93, 8–16.CrossRefGoogle Scholar
STEERE, A. C., BRODERICK, T. F. & MALAWISTA, S. E. ( 1978). Erythema chronicum migrans and Lyme arthritis: epidemiologic evidence for a tick vector. American Journal of Epidemiology 108, 312–321.CrossRefGoogle Scholar
STEERE, A. C. & MALAWISTA, S. E. ( 1979). Cases of Lyme disease in the United States: locations correlated with distribution of Ixodes dammini. Annals of Internal Medicine 91, 730–733.CrossRefGoogle Scholar
STEERE, A. C., MALAWISTA, S. E., HARDIN, J. A., RUDDY, S., ASKENASE, W. & ANDIMAN, W. A. ( 1977 a). Erythema chronicum migrans and Lyme arthritis. The enlarging clinical spectrum. Annals of Internal Medicine 86, 685–698.Google Scholar
STEERE, A. C., MALAWISTA, S. E., SNYDMAN, D. R., SHOPE, R. E., ANDIMAN, W. A., ROSS, M. R. & STEELE, F. M. ( 1977 b). Lyme arthritis: an epidemic of oligoarticular arthritis in children and adults in three Connecticut communities. Arthritis and Rheumatology 20, 7–17.Google Scholar
STEERE, A. C., SIKAND, V. K., MEURICE, F., PARENTI, D. L., FIKRIG, E., SCHOEN, R. T., NOWAKOWSKI, J., SCHMID, C. H., LAUKAMP, S., BUSCARINO, C. & KRAUSE, D. S. ( 1998). Vaccination against Lyme disease with recombinant Borrelia burgdorferi outer-surface lipoprotein A with adjuvant. Lyme Disease Vaccine Study Group. New England Journal of Medicine 339, 209–215.Google Scholar
STEVENSON, B., EL-HAGE, N., HINES, M. A., MILLER, J. C. & BABB, K. ( 2002). Differential binding of host complement inhibition factor H by Borrelia burgdorferi erp surface proteins: a possible mechanism underlying the expansive host range of Lyme disease spirochetes. Infection and Immunity 70, 491–497.CrossRefGoogle Scholar
STRLE, F., PICKEN, R. N., CHENG, Y., CIMPERMAN, J., MARASPIN, V., LOTRIC-FURLAN, S., RUZIC-SABLJIC, E. & PICKEN, M. M. ( 1997). Clinical findings for patients with Lyme borreliosis caused by Borrelia burgdorferi sensu lato with genotypic and phenotypic similarities to strain 25015. Clinical Infectious Diseases 25, 273–280.Google Scholar
STUNZNER, D., HUBALEK, Z., HALOUZKA, J., POSTIC, D., PIERER, K. & MARTH, E. ( 1998). Prevalence of Borrelia burgdorferi s.l. in Ixodes ricinus ticks from Styria (Austria) and species identification by PCR-RFLP analysis. Zentralblatt für Bakteriologie 228, 471–478.Google Scholar
TÄLLEKLINT, L. & JAENSON, T. G. T. ( 1993). Maintenance by hares of European Borrelia burgdorferi in ecosystems without rodents. Journal of Medical Entomology 30, 273–276.CrossRefGoogle Scholar
TÄLLEKLINT, L. & JAENSON, T. G. T. ( 1994). Transmission of Borrelia burgdorferi s.l. from mammal reservoirs to the primary vector of Lyme borreliosis, Ixodes ricinus (Acari: Ixodidae), in Sweden. Journal of Medical Entomology 31, 880–886.Google Scholar
TÄLLEKLINT, L. & JAENSON, T. G. T. ( 1995). Control of Lyme borreliosis in Sweden by reduction of tick vectors: an impossible task? International Journal of Angiology 4, 34–37.Google Scholar
TÄLLEKLINT, L. & JAENSON, T. G. T. ( 1996). Seasonal variations in density of questing Ixodes ricinus (Acari: Ixodidae) nymphs and prevalence of infection with Borrelia burgdorferi sl in south central Sweden. Journal of Medical Entomology 33, 592–597.CrossRefGoogle Scholar
TÄLLEKLINT-EISEN, L. & LANE, R. S. ( 1999). Variation in the density of questing Ixodes pacificus (Acari: Ixodidae) nymphs infected with Borrelia burgdorferi at different spatial scales in California. Journal of Parasitology 85, 824–831.CrossRefGoogle Scholar
TELFORD, S. R. III, MATHER, T. N., ADLER, G. H. & SPIELMAN, A. ( 1990). Short-tailed shrews as reservoirs of the agents of Lyme disease and human babesiosis. Journal of Parasitology 76, 681–683.Google Scholar
TELFORD, S. R. III, MATHER, T. N., MOORE, S. L., WILSON, M. L. & SPIELMAN, A. ( 1988). Incompetence of deer as reservoirs of the Lyme disease spirochete. American Journal of Tropical Medicine and Hygiene 39, 105–109.CrossRefGoogle Scholar
TOUTOUNGI, L. N., GERN, L., AESCHLIMANN, A. & DEBROT, S. ( 1991). A propos du genre Pholeoixodes, parasite des carnivores en Suisse. Acarologia XXXII, 311–328.Google Scholar
TOUTOUNGI, L., AESCHLIMANN, A. & GERN, L. ( 1993). Biology of immature stages of Pholeoixodes hexagonus under laboratory conditions. Experimental and Applied Acarology 17, 655–662.CrossRefGoogle Scholar
VAN DAM, A. P., KUIPER, H., VOS, K., WIDJOJOKUSUMO, A., DE JONGH, B. M., SPANJAARD, L., RAMSELAAR, A. C. P., KRAMER, M. D. & DANKERT, J. ( 1993). Different genospecies of Borrelia burgdorferi are associated with distinct clinical manifestations of Lyme borreliosis. Clinical Infectious Disease 17, 708–717.Google Scholar
VAN DAM, A. P., OEI, A., JASPARS, R., FIJEN, C., WILSKE, B., SPANJAARD, L. & DANKERT, J. ( 1997). Complement-mediated serum sensitivity among spirochetes that cause Lyme disease. Infection and Immunity 65, 1228–1236.Google Scholar
VASILIU, V., HERZER, P., ROESSLER, D., LEHNERT, G. & WILSKE, B. ( 1998). Heterogeneity of Borrelia burgdorferi sensu lato demonstrated by an ospA-type specific PCR in synovial fluid from patients with Lyme arthritis. Medical Microbiology and Immunology 187, 97–102.CrossRefGoogle Scholar
WALKER, A. R. ( 2001). Age structure of a population of Ixodes ricinus (Acari: Ixodidae) in relation to its seasonal questing. Bulletin of Entomological Research 91, 69–78.Google Scholar
WANG, G., VAN DAM, A. P., LE FLECHE, A., POSTIC, D., PETER, O., BARANTON, G., DE BOER, R., SPANJAARD, L. & DANKERT, J. ( 1997). Genetic and phenotypic analysis of Borrelia valaisiana sp. nov. (Borrelia genomic groups VS116 and M19). International Journal of Systematic Bacteriology 47, 926–932.CrossRefGoogle Scholar
WANG, G., VAN DAM, A. P., SCHWARTZ, I. & DANKERT, J. ( 1999). Molecular typing of Borrelia burgdorferi sensu lato: taxonomic, epidemiological and clinical implications. Clinical Microbiology Review 12, 633–635.Google Scholar
WANG, G. Q., VAN DAM, A. P. & DANKERT, J. ( 1999). Phenotypic and genetic characterization of a novel Borrelia burgdorferi sensu lato isolate from a patient with Lyme borreliosis. Journal of Clinical Microbiology 37, 3025–3028.Google Scholar
WEBER, K. & PFISTER, H.-W. ( 1993). History of Lyme borreliosis in Europe. In Aspects of Lyme borreliosis ( ed. Weber, K. & Burgdorfer, W.), pp. 1–20. Springer Verlag, Berlin, Heidelberg.CrossRef
WEISBROD, A. R. & JOHNSON, R. C. ( 1989). Lyme disease and migrating birds in the Saint Croix River Valley. Applied and Environmental Microbiology 55, 1921–1924.Google Scholar
WESTROM, D. R., LANE, R. S. & ANDERSON, J. R. ( 1985). Ixodes pacificus (Acari: Ixodidae): population dynamics and distribution on Columbian black-tailed deer (Odocoileus hemionus columbianus). Journal of Medical Entomology 22, 507–511.CrossRefGoogle Scholar
WILL, G., JAURIS-HEIPKE, S., SCHWAB, E., BUSCH, U., RÖSSLER, D., SOUTSCHEK, E., WILSKE, B. & PREAC-MURSIC, V. ( 1995). Sequence analysis of ospA genes shows homogeneity within Borrelia burgdorferi sensu stricto and Borrelia afzelii strains but reveals major subgroups within the Borrelia garinii species. Medical Microbiology and Immunology 184, 73–80.CrossRefGoogle Scholar
WILSKE, B., BUSCH, U. B., EIFFERT, H., FINGERLE, V., PFISTER, H. W. & PREAC-MURSIC, V. ( 1996). Diversity of OspA and OspC among cerebrospinal fluid isolates of Borrelia burgdorferi sensu lato from patients with neuroborreliosis in Germany. Medical Microbiology and Immunology 184, 195–201.CrossRefGoogle Scholar
WILSKE, B., JAURIS-HEIPKE, S., LOBENTANZER, R., PRADEL, I., PREAC-MURSIC, V., ROSSLER, D., SOUTSCHEK, E. & JOHNSON, R. C. ( 1995). Phenotypic analysis of outer surface protein C (OspC) of Borrelia burgdorferi sensu lato by monoclonal antibodies: relationship to genospecies and OspA serotype. Journal of Clinical Microbiolology 33, 103–109.Google Scholar
WILSKE, B., PREAC-MURSIC, U. B., GOBEL, B., GRAF, S., JAURIS, E., SOUTSCHEK, E., SCHWAB, E. & ZUMSTEIN, G. ( 1993). An OspA serotyping system for Borrelia burgdorferi based on reactivity with monoclonal antibodies and OspA sequence analysis. Journal of Clinical Microbiolology 31, 340–350.Google Scholar
WILSON, M. L. ( 1986). Reduced abundance of adult Ixodes dammini (Acari: Ixodidae) following destruction of vegetation. Journal of Economic Entomology 79, 693–696.CrossRefGoogle Scholar
WILSON, M. L., ADLER, G. H. & SPIELMAN, A. ( 1985). Correlation between deer abundance and that of the deer tick Ixodes dammini (Acari: Ixodidae). Annals of the Entomological Society of America 78, 172–176.CrossRefGoogle Scholar
WILSON, M. L., TELFORD, S. R. III, PIESMAN, J. & SPIELMAN, A. ( 1988). Reduced abundance of immature Ixodes dammini (Acari: Ixodidae) following elimination of deer. Journal of Medical Entomology 25, 224–228.CrossRefGoogle Scholar
WORMSER, G. P., BITTKER, S., COOPER, D., NOWAKOWSKI, J., NADELMAN, R. B. & PAVIA, C. ( 2001). Yield of large-volume blood cultures in patients with early Lyme disease. Journal of Infectious Diseases 184, 1070–1072.CrossRefGoogle Scholar
WORMSER, G. P., LIVERIS, D., NOWAKOWSKI, J., NADELMAN, R. B., CAVALIERE, L. F., McKENNA, D., HOLMGREN, D. & SCHWARTZ, I. ( 1999). Association of specific subtypes of Borrelia burgdorferi with hematogenous dissemination of early Lyme disease. Journal of Infectious Diseases 180, 720–725.CrossRefGoogle Scholar
WORMSER, G. P., NADELMAN, R. D., DATTWYLER, R. J., DENNIS, D. T., SHAPIRO, E. D., STEERE, A. C., RUSH, T. J., RAHN, D. W., COYLE, P. K., PERSING, D. H., FISH, D. & LUFT, B. J. ( 2000). Practice guidelines for the treatment of Lyme disease. Clinical Infectious Diseases 31 (Suppl.), S1–S14.CrossRefGoogle Scholar
WRIGHT, S. A., THOMPSON, M. A., MILLER, M. J., KNERL, K. M., ELMS, S. L., KARPOWICZ, J. C., YOUNG, J. F. & KRAMER, V. L. ( 2000). Ecology of Borrelia burgdorferi in ticks (Acari: Ixodidae), rodents, and birds in the Sierra Nevada foothills, Placer County, California. Journal of Medical Entomology 37, 909–918.CrossRefGoogle Scholar
YOUNSI, H., POSTIC, D., BARANTON, G. & BOUATTOUR, A. ( 2001). High prevalence of Borrelia lusitaniae in Ixodes ricinus ticks in Tunisia. European Journal of Epidemiology 17, 53–56.CrossRefGoogle Scholar
YUVAL, B. & SPIELMAN, A. ( 1990). Duration and regulation of the development cycle of Ixodes dammini (Acari: Ixodidae). Journal of Medical Entomology 27, 196–201.CrossRefGoogle Scholar
ZEIDNER, N. S., NUNCIO, M. S., SCHNEIDER, B. S., GERN, L., PIESMAN, J., BRANDO, O. & FILIPE, A. R. ( 2001). A Portuguese isolate of Borrelia lusitaniae induces disease in C3H/HeN mice. Journal of Medical Microbiology 50, 1055–1060.CrossRefGoogle Scholar
ZHIOUA, E., BOUATTOUR, A., HU, C. M., GHARBI, M., AESCHLIMANN, A., GINSBERG, H. & GERN, L. ( 1999). Infections of Ixodes ricinus (Acari: Ixodidae) by Borrelia burgdorferi sensu lato in North Africa (Tunisia). Journal of Medical Entomology 36, 216–218.CrossRefGoogle Scholar
ZHIOUA, E., BROWNING, M., JOHNSON, P. W., GINSBERG, H. S. & LEBRUN, R. A. ( 1997). Pathogenicity of the entomopathogenic fungus Metarhizium anisopliae (Deuteromycetes) to Ixodes scapularis (Acari: Ixodidae). Journal of Parasitology 83, 815–818.CrossRefGoogle Scholar
ZHIOUA, E., LEBRUN, R. A., GINSBERG, H. S. & AESCHLIMANN, A. ( 1995). Pathogenicity of Steinernema carpocapsae and S. glaseri (Nematoda: Steinernematidae) to Ixodes scapularis (Acari: Ixodidae). Journal of Medical Entomology 32, 900–905.Google Scholar
ZHU, Z. ( 1998). Histological observations on Borrelia burgdorferi growth in naturally infected female Ixodes ricinus. Acarologia 39, 11–22.Google Scholar