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Lipid metabolism in golden hamsters infected with plerocercoids of Spirometra erinacei (Cestoda: Pseudophyllidea)

Published online by Cambridge University Press:  06 April 2009

T. Tsuboi  and
K. Hirai
T. Tsuboi
Affiliation:
Department of Parasitology, Ehime University School of Medicine, Shigenobu-cho, Ehime 791–02, Japan
K. Hirai
Affiliation:
Department of Parasitology, Ehime University School of Medicine, Shigenobu-cho, Ehime 791–02, Japan
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Summary

Golden hamsters infected with Spirometra erinacei plerocercoids develop a hypertriglyceridaemia characterized by an increase in very low-density lipoprotein. Acyl-CoA synthetase activity, the rate of fatty acid synthesis in the liver and triglyceride production studies showed that the activation and synthesis of fatty acid and production of triglyceride in plerocercoidinfected hamsters were not significantly different from the controls. Lipase activity in post-heparin plasma was found to be suppressed in plerocercoid-infected golden hamsters. The presence of plerocercoids also resulted in a significant reduction in serum thyroxine, but the hypertriglyceridaemia associated with plerocercoid infection was not reversed by injecting the infected hamsters with 2 μg/ day doses of L-thyroxine. The levels of serum immunoreactive insulin in plerocercoid-infected hamsters were not significantly different from the controls. We conclude that the hypertriglyceridaemia, associated with plerocercoid infection in hamsters, results predominantly from a suppression of triglyceride degradation, and that the suppression of lipase activity is probably not the result of hypothyroidism or the lack of insulin, but the result of secretion of growth hormone-like substances.

Type
Research Article
Information
Parasitology , Volume 93 , Issue 1 , August 1986 , pp. 143 - 151
Copyright
Copyright © Cambridge University Press 1986

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