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Isolates of Trichuris muris vary in their ability to elicit protective immune responses to infection in mice

Published online by Cambridge University Press:  06 April 2009

T. Bellaby ,
K. Robinson ,
D. Wakelin  and
J. M. Behnke
T. Bellaby
Affiliation:
Department of Life Science, University of Nottingham, University Park, Nottingham NG7 2RD
K. Robinson
Affiliation:
Department of Life Science, University of Nottingham, University Park, Nottingham NG7 2RD
D. Wakelin
Affiliation:
Department of Life Science, University of Nottingham, University Park, Nottingham NG7 2RD
J. M. Behnke
Affiliation:
Department of Life Science, University of Nottingham, University Park, Nottingham NG7 2RD
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Summary

Much of what is currently known of the host-parasite interaction between mice and the parasitic nematode Trichuris muris has come from experiments using a single parasite isolate (E/N). This isolate has been compared with 2 others which, on morphological criteria, belong to the same species. In 3 inbred strains of mouse that show distinct, genetically determined response phenotypes, there was a consistent pattern in terms of parasite survival time regardless of host strain, E/K worms being expelled early, E/N expelled later and S worms very late or not at all. High-responder CBA mice expelled E/K and E/N worms earlier than low-responder C57 B1/10 mice. B10.BR mice were permissive to S isolate infection, mounted a very late response to E/N worms but expelled E/K worms effectively by day 25. The differential response of mice to these isolates provides an experimental system for identifying the basis of variation in this host-parasite relationship.

Keywords

Trichuris murisnematodeparasite isolatemouse strainresponse phenotypehost genetics
Type
Research Article
Information
Parasitology , Volume 111 , Issue 3 , September 1995 , pp. 353 - 357
Copyright
Copyright © Cambridge University Press 1995

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