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Invasion of mature and immature erythrocytes of CBA/Ca mice by a cloned line of Plasmodium chabaudi chabaudi

Published online by Cambridge University Press:  06 April 2009

W. Jarra  and
K. N. Brown
W. Jarra
Affiliation:
Division of Parasitology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA
K. N. Brown
Affiliation:
Division of Parasitology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA
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Summary

During the early stages of the primary Plasmodium chabaudi chabaudi AS parasitaemia in CBA/Ca mice this parasite invaded normocytes, but as the parasitaemia developed increasing numbers of parasites were seen within reticulocytes. During and just after peak parasitaemia, as further parasite replication was controlled, the ‘crisis’ phase ensued, mice became increasingly anaemic and reticulocyte numbers were markedly increased. As the parasitaemia was resolved during crisis in excess of 25% of parasites had invaded reticulocytes. In phenylhydrazine-pretreated mice with artificially high reticulocyte levels and infected with P. c. chabaudi AS, normocyte/reticulocyte invasion occurred with equal frequency. No reduction in the infectivity of parasite populations developing in reticulocytes was observed.

Keywords

Plasmodium chabaudi chabaudimalariaerythrocytesreticulocytesinvasionphenylhydrazine
Type
Research Article
Information
Parasitology , Volume 99 , Issue 2 , October 1989 , pp. 157 - 163
Copyright
Copyright © Cambridge University Press 1989

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References

Bates, M. D., Newbold, C. L., Jarra, W. & Brown, K. N. (1988). Protective immunity to malaria: studies with cloned lines of Plasmodium chabaudi chabaudi in CBA/Ca mice. III Protective and suppressive responses induced by immunization with purified antigens. Parasite Immunology 10, 1–15.CrossRefGoogle ScholarPubMed
Brown, K. N., Berzins, K., Jarra, W. & Schetters, T. (1986). Immune responses to crythrocytic malaria. In Clinics in Immunology and Allergy, vol. 6, (ed. Britten, V. & Hughes, H. P. A.) pp. 227–249. London, Philadelphia, Toronto: W. B. Saunders.Google Scholar
Carter, R. &Walliker, D. (1975). New observations of the malaria parasites of the Central African Republic, Plasmodium vinckei petteri subsp. nov and P. chabaudi Landau (1965). Annals of Tropical Medicine and Parasitology 69, 187–96.Google Scholar
Cox, F. E. G. (1974). A comparative account of the effects of betamethasone on mice infected with Plasmodium vinckei chabaudi and P. berghei yoelii. Parasitology 68, 19–26.CrossRefGoogle Scholar
Garnham, P. C. C. (1966). Malaria Parasites and Other Haemosporidia. Oxford: Blackwell.Google Scholar
Jarra, W. (1982). Studies on the induction and expression of protective immunity in rodent malaria: Plasmodium berghei and P. c. chabaudi infections of inbred mice. Ph.D. thesis, Brunel University.Google Scholar
Jarra, W. & Brown, K. N. (1985). Protective immunity to malaria: studies with cloned lines of Plasmodium chabaudi and P. berghei in CBA/Ca mice. I. The effectiveness and inter- and intra-species specificity of immunity induced by infection. Parasite Immunology 7, 595–606.CrossRefGoogle ScholarPubMed
Jarra, W. & Brown, K. N. (1989). Protective immunity to malaria: studies with cloned lines of rodent malaria in CBA/Ca mice. IV. The specificity of mechanisms resulting in crisis and resolution of the primary acute phase parasitaemia of Plasmodium chabaudi chabaudi and P. yoelii yoelii. Parasite Immunology 11, 1–13.CrossRefGoogle ScholarPubMed
Jarra, W., Hills, L. A., March, J. C., & Brown, K. N. (1986). Protective immunity to malaria. Studies with cloned lines of Plasmodium chabaudi chabaudi and P. berghei in CBA/Ca mice. II. The effectiveness and inter- or intra-species specificity of the passive transfer of immunity with serum. Parasite Immunology 8, 239–54.CrossRefGoogle ScholarPubMed
Jayawardena, A. N., Mogh, R., Murphy, D. B., Burger, D. & Gershon, R. K. (1983). Enhanced expression of H-2K and H-2D antigens on reticulocytes infected with Plasmodium yoelii. Nature, London 302, 623–6.Google Scholar
Ladda, R. & Lalli, F. (1966). The course of Plasmodium berghei infection in the polycythemic mouse. Journal of Parasitology 52, 383–5.Google Scholar
McDonald, V. (1977). The protective immune response in mice to Plasmodium chabaudi Ph.D. thesis, University of Glasgow.Google Scholar
McDonald, V. & Phillips, R. S. (1978). Plasmodium chabaudi in mice. Adoptive transfer of immunity with enriched population of spleen T and B lymphocytes. Immunology 34, 821–30.Google ScholarPubMed
Ott, K. J. (1968). Influence of reticulocytosis on the course of infection of Plasmodium chabaudi and P. berghei. Journal of Protozoology 15, 365–9.CrossRefGoogle ScholarPubMed
Poels, L. G., Van Niekerk, C. C., Franken, M. A. M. &Van Elvin, E. H. (1977). Plasmodium berghei berghei: selective release of ‘protective’ antigens. Experimental Parasitology 42, 182–93.CrossRefGoogle ScholarPubMed
Ramakrishnan, S. P. & Prakash, S. (1950). Studies on Plasmodium berghei n.sp. Vinke and Lips 1948. II.Morphology, periodicity and pathogeneity in blood induced infection in mice, rats and garden squirrels. Indian Journal of Malariology 4, 369–75Google Scholar
Rigdon, R. H., Micks, D. W. & Breslin, D. (1950). Effect of phenylhydrazine hydrochloride on Plasmodium knowlesi infection in the monkey. American Journal of Hygiene 52, 308–22.Google ScholarPubMed
Schetters, T. P. M., Van Zon, A. A. J. G. & Eling, W. M. C. (1986). Plasmodium berghei: Relative immunogenicity of infected reticulocytes and infected oxyphilic red blood cells. Experimental Parasitology 62, 322–8.CrossRefGoogle ScholarPubMed
Schwink, T. M.. (1960). The effect of anti-erythrocyte antibodies upon Plasmodium berghei infection in white mice. American Journal of Tropical Medicine and Hygiene 9, 293–6.Google Scholar
Singer, I. (1953). The effect of X-irradiation on infections with Plasmodium berghei in the white mouse. Journal of Infectious Diseases 92, 97–104.CrossRefGoogle ScholarPubMed
Singer, I. (1954). The effect of splenectomy or phenylhydrazine on infections with Plasmodium berghei in the white mouse. Journal of Infectious Diseases 94, 159–72.CrossRefGoogle ScholarPubMed
Singer, I., Hadfield, R. & Lakonen, M. (1955). The influence of age on the intensity of infection with Plasmodium berghei in the rat. Journal of Infectious Diseases 97, 15–21.Google Scholar
Viens, P., Chevalier, J. L., Sonea, S. & Yoeli, M. (1971). The effect of reticulocytosis on Plasmodium vinckei infections in white mice. Action of phenylhydrazine and of repeated bleedings. Canadian Journal of Microbiology 17, 257–61.CrossRefGoogle ScholarPubMed
Walliker, D. (1983). The Contribution of Genetics to the Study of Parasitic Protozoa. Research Studies Press, Tropical Medicine Series. New York, London: John Wiley & Sons.Google Scholar
Yoeli, M., Hargreaves, B., Carter, R. & Walliker, D. (1975). Sudden increase in Virulence in a strain of Plasmodium berghei yoelii. Annals of Tropical Medicine and Parasitology 69, 173–8.Google Scholar
Zuckerman, A. (1957). Blood loss and replacement in plasmodial infections. I. Plasmodium berghei in untreated rats of varying age and in adult rats with erythropoietic mechanisms manipulated before inoculation. Journal of Infectious Diseases 100, 172–206.CrossRefGoogle ScholarPubMed
Zuckerman, A. (1958). Blood loss and replacement in plasmodial infections. II. Plasmodium vinckei in untreated weanling and mature rats. Journal of Infectious Diseases 103, 205–24.Google Scholar