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Immunodepression in Babesia microti infections

Published online by Cambridge University Press:  06 April 2009

Anne C. Purvis
Anne C. Purvis
Affiliation:
Department of Zoology, University of London, King's College, Strand, London WC2R 2LS
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Extract

Infection with the avirulent piroplasm Babesia microti in mice is accompanied by a marked depression in the ability of the mice to mount an immune response to sheep red blood cells. The period of immunodepression begins 3 days after peak parasitaemia and is maximal 4 days later. There-after, there is a slow return to normal immune responsiveness, correlated with the gradual disappearance of the parasites from the blood. Both IgM and IgG responses are depressed. Cell-mediated responses as determined by contact sensitivity to oxazolone and allograft survival are apparently unaffected. Phagocytic activity as measured by carbon clearance tests is increased, and is correlated with the parasitaemia.

Type
Research Article
Information
Parasitology , Volume 75 , Issue 2 , October 1977 , pp. 197 - 205
Copyright
Copyright © Cambridge University Press 1977

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