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Immunization of pigs against infection with Schistosoma japonicum using ultraviolet-attenuated cercariae

Published online by Cambridge University Press:  06 April 2009

Y.-E. Shi ,
C.-F. Jiang ,
J.-J. Han ,
Y.-L. Li  and
A. Ruppel
Y.-E. Shi
Affiliation:
Department of Parasitology, Tongji Medical University, Hankong Lu 13, Wuhan, 430030, People's Republic of China
C.-F. Jiang
Affiliation:
Department of Parasitology, Tongji Medical University, Hankong Lu 13, Wuhan, 430030, People's Republic of China
J.-J. Han
Affiliation:
Department of Parasitology, Tongji Medical University, Hankong Lu 13, Wuhan, 430030, People's Republic of China
Y.-L. Li
Affiliation:
Department of Parasitology, Tongji Medical University, Hankong Lu 13, Wuhan, 430030, People's Republic of China
A. Ruppel
Affiliation:
Institute for Tropical Hygiene, Im Neuenheimer Feld 324, D-6900 Heidelberg, Germany
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Summary

Since pigs are important in the zoonotic transmission of schistosomiasis japonica in China, a veterinary vaccine might contribute to the control of the disease in humans. Pigs were immunized with three doses each of 10000 cercariae of Schistosoma japonicum attenuated with ultraviolet light (400 μWatt·min/cm2). The experiment was performed with portable irradiation equipment in a rural area of the Hubei Province (P.R. China). A challenge infection of 1000 untreated cercariae was given 2·5 or 6 months after the last immunization, and age-matched naive pigs were challenged as a control. Immunized pigs developed about 90% resistance against the challenge. The liver egg load of these animals was reduced by over 90%. Less than 0·01 % of the immunizing cercariae developed to adult parasites and the vaccination had no apparent adverse influence on the pigs' health.

Keywords

Schistosoma japonicumpigsvaccinationultraviolet lightattenuationcercariae
Type
Research Article
Information
Parasitology , Volume 106 , Issue 5 , June 1993 , pp. 459 - 462
Copyright
Copyright © Cambridge University Press 1993

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