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Immunity to Trichinella spiralis

I. The immunity produced by mice to the first four days of the intestinal phase of the infection

Published online by Cambridge University Press:  06 April 2009

D. A. Denham
D. A. Denham
Affiliation:
Department of Animal Pathology, Madingley Road, Cambridge*
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Extract

Single infections of Trichinella spiralis of 48 h duration did not produce a significant degree of immunity in mice.

Single or triple light infections of 7 h duration which, it is suggested, were composed entirely of fourth-stage larvae, did not produce significant immunity.

Single infections of 3 or 4 days duration did produce immunity. It is suggested that the fourth-stage intestinal larvae and the fourth moult are not the most important sources of immunizing antigen in a T. spiralis infection.

I would like to express my gratitude to H.M. Treasury and to the Agricultural Research Council for financial support during the time that this work was being conducted. I would also like to thank Professor W. I. B. Beveridge, within whose department this work was conducted, for the facilities provided. The helpful advice of my colleagues R. M. Connan and R. S. Phillips was of great value during the time that this manuscript was being prepared for publication.

Type
Research Article
Information
Parasitology , Volume 56 , Issue 2 , May 1966 , pp. 323 - 327
Copyright
Copyright © Cambridge University Press 1966

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References

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