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Immunity to Plasmodium berghei in rats: maximum levels of protective antibody activity are associated with eradication of the infection

Published online by Cambridge University Press:  06 April 2009

R. S. Phillips  and
Valerie E. Jones
R. S. Phillips
Affiliation:
National Institute for Medical Research, London NW7 1AA
Valerie E. Jones
Affiliation:
National Institute for Medical Research, London NW7 1AA
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Extract

Maximum levels of protective antibody activity were reached in the circulation of rats given a primary infection or one or two re-infections of Plasmodium berghei at the time the infection was finally eradicated. This association of maximum protective antibody activity with complete clearance of the parasite was also found in recipients of lymphoid cells from immune donor rats and suggests that a high level of protective antibody activity is one essential factor in complete elimination of the parasite.

Excellent technical assistance was given at different times by Mrs J. Page, Mr A. J. Edwards and Miss D. Leader.

Type
Research Article
Information
Parasitology , Volume 64 , Issue 1 , February 1972 , pp. 117 - 127
Copyright
Copyright © Cambridge University Press 1972

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References

REFERENCES

Briggs, N. T. & Wellde, B. T. (1969). Some characteristics of Plasmodium berghei ‘relapsing’ in immunized mice. Military Medicine 134, 1243–8.CrossRefGoogle ScholarPubMed
Briggs, N. T., Wellde, B. T. & Sadun, E. H. (1968). Variants of Plasmodium berghei resistant to passive transfer of immune serum. Experimental Parasitology 22, 338–46.CrossRefGoogle ScholarPubMed
Brown, I. N. (1969). Immunological aspects of malaria infections. Advances in Immunology 11, 267–349.CrossRefGoogle Scholar
Brown, K. N. (1971). Protective immunity to malaria provides a model for the survival of cells in an immunologically hostile environment. Nature, London 230, 163–7.CrossRefGoogle Scholar
Brown, K. N. & Phillips, R. S. (1971). The role of the thymus-derived lymphocytes in protective immunity to malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene 65, 7.Google ScholarPubMed
Cox, H. W. (1962). The behaviour of Plasmodium berghei strains isolated from relapsed infections of white mice. Journal of Protozoology 9, 114–18.CrossRefGoogle Scholar
Diggs, C. L. & Osler, A. G. (1969). Humoral immunity in rodent malaria. II. Inhibition of parasitaemia by serum antibody. Journal of Immunology 102, 298–305.CrossRefGoogle ScholarPubMed
Hanna, M. G. & Peters, L. C. (1970). The effect of antigen competition in both primary and secondary immune capacity in mice. Journal of Immunology 104, 166–77.CrossRefGoogle ScholarPubMed
Jones, V. E. (1969). Rat 7S immunoglobulins: characterization of γ1- and γ2-antihapten antibodies. Immunology 16, 589–99.Google Scholar
Jones, V. E., Edwards, A. J. & Ogilvie, B. M. (1970). The circulating immunoglobulins involved in protective immunity to the intestinal stage of Nippostrongylus brasiliensis in the rat. Immunology 18, 621–33.Google Scholar
Krebs, H. A. & Eggleston, L. V. (1940). The oxidation of pyruvate in pigeon breast muscle. Biochemical Journal 34, 442–51.CrossRefGoogle ScholarPubMed
Mackaness, G. B. (1967). The relationship of delayed hypersensitivity to acquired cellular immunity. British Medical Bulletin 23, 52–4.CrossRefGoogle Scholar
Phillips, R. S. (1970). Plasmodium berghei: passive transfer of immunity by antiserum and cells. Experimental Parasitology 27, 479–95.CrossRefGoogle ScholarPubMed
Phillips, R. S. (1971). Evidence that piroplasms can undergo antigenic variation. Nature 231, 323.CrossRefGoogle ScholarPubMed
Salaman, M. H., Wedderburn, N. & Bruce-Chwatt, L. J. (1969). The immuno-depressive effect of a murine Plasmodium and its interaction with murine oncogenic viruses. Journal of General Microbiology 59, 383–91.CrossRefGoogle Scholar
Stechschulte, D. J., Briggs, N. T. & Wellde, B. T. (1969). Characterization of protective antibodies produced in Plasmodium berghei infected rats. Military Medicine 134, 1140–52.CrossRefGoogle ScholarPubMed