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Immunity in trypanosomiasis I. Neutralization reaction

Published online by Cambridge University Press:  06 April 2009

M. A. Soltys
M. A. Soltys
Affiliation:
Department of Animal Pathology, University of Cambridge
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Extract

A study of neutralization reaction of trypanosomes with immune sera made against them is recorded, together with a description of the technique.

Neutralizing antibody appears in rabbits infected with T. brucei 5 days after infection and reaches its peak (1/320) within 28 days.

The same titre of neutralizing antibody can be produced in rabbits by a series of injections of dead formalized trypanosomes.

Antibody titres persist at high levels for a longer period in animals infected and subsequently treated than in animals immunized with dead trypanosomes.

Neutralizing antibody can be demonstrated in infected guinea-pigs but on a much lower level than in rabbits. Mice and rats infected with T. brucei and not treated failed to show demonstrable neutralizing antibody.

Mice infected with T. brucei can be protected from infection by inoculation at the same time, or even 1 hr. later, with 0·5 ml. of antiserum showing a high level of neutralizing antibody.

Mice inoculated with the same antiserum showed passive immunity lasting for 10 days.

The evidence that T. brucei ‘O‘ after passages through rabbits failed to be neutralized by homologous or heterologous sera which, on the other hand, were able to neutralize the parent strain, suggests that strains after passage through rabbits were not genetic variants, but developed a protective mechanism against immune bodies.

Type
Research Article
Information
Parasitology , Volume 47 , Issue 3-4 , December 1957 , pp. 375 - 389
Copyright
Copyright © Cambridge University Press 1957

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References

Braun, H. & Teichmann, E. (1912). Ueber Trypanosomen Immunisierung. Dtsch. med. Wschr. 38, 107.CrossRefGoogle Scholar
Ehrlich, P. (1911). Ueber chemotherapie. Zbl. Bakt. Abt. 1, Ref. 50 (Beiheft), 94.Google Scholar
Ehrlich, P., Roehi, W. & Gulbransen, R. (1909). Ueber serumfeste Trypanosomenstämme Z. ImmunForsch. 3, 296.Google Scholar
Franke, E. (1905). Therapeutische Versuche bei Trypanosomenerkrankung. Münch. med. Wschr. 52 (II), 2059.Google Scholar
Kligler, I. J., Olitzki, L. & Kligler, H. (1940). The antigenio composition and immunizing properties of Trypanosomes. J. Immunol. 38, 317.CrossRefGoogle Scholar
Kudicke, R. (1911). Beiträge zur Biologie der Trypanosomen. Zbl. Bakt. Abt. 1, 61, 113.Google Scholar
Laveran, A. (1911). Essai de vaccination contre le Trypanosoma gambiense avec des trypanosomes morts: toxine de Tr. gambiense. Bull. Soc. Pat. exot. 4, 680.Google Scholar
Laveran, A. & Mesnil, F. (1902). Recherches sur le traitement et la prévention du nagana. Ann. Inst. Pasteur, 16, 785.Google Scholar
Leopold, F. (1928). Untersuchungen über Recidivstämme bei Trypanosomen mit Hilfe des Rieckenberg Phänomens. Z. Hyg. InflektKr. 109, 144.CrossRefGoogle Scholar
Levaditi, C. & McIntosh, J. (1910). Mécanisme de la création de races de trypanosomes résistantes au anticorps. Bull. Soc. Pat. exot. 3, 368.Google Scholar
Lourie, E. M. & O'Connor, R. J. (1937). A study of Trypanosoma rhodesiense relapse strains in vitro. Ann. Trop. Med. Parasit. 31, 319.CrossRefGoogle Scholar
Manteufel, P. (1909). Studien über die Trypanosomiasis der Ratten mit Berücksichtigung der Übertragung unter natürlichen Verhältnissen und der Immunität. Arb. GesundhAmt., Berl., 33, 46.Google Scholar
Martini, E. (1905). Untersuchungen über die Tsetsekrankheit zwecks Immunisierung von Haustieren. Z. Hyg. InfektKr. 50, 1.CrossRefGoogle Scholar
Mesnil, F. & Brimont, E. (1909). Sur les propriétés protectrices du sérum des animaux trypanosomies. Races résistantes à ces sérums. Ann. Inst. Pasteur. 23, 129.Google Scholar
Raffel, S. (1934). Studies in immunity to trypanosomes. I. Acquired immunity to Trypanosoma equiperdum in infected rats. The Rieckenberg reaction. Amer. J. Hyg. 19, 416.Google Scholar
Ritz, H. (1914). Ueber Rezidive bei experimenteller Trypanosomiasis. Dtsch. med. Wschr. 40, 1355.CrossRefGoogle Scholar
Ritz, H. (1916). Ueber Rezidive bei experimenteller Trypanosomiasis. II. Arch. Schiffs-u. Tropenhyg. 20, 397.Google Scholar
Ross, R. & Thomson, J. G. (1910). Experiments on the treatment of animals infected with trypanosomes by means of atoxyl, vaccines, cold, X-rays and leucocytic extract: enumerative methods employed. Proc. Roy. Soc. B, 83, 227.Google Scholar
Russell, H. (1936). Observations on immunity in relapsing fever and Trypanosomiasis. Trans. R. Soc. Trop. Med. Hyg. 30, 179.CrossRefGoogle Scholar
Taliaferro, W. H. (1929). The Immunity of Parasitic Infections, pp. 108–72. New York: The Century Co.Google Scholar
Taliaferro, W. H. (1941). Populations of blood-dwelling species. Amer. Nat. 75, 458.CrossRefGoogle Scholar
Wood, W. B. Jr. & Smith, M. R. (1949). Inhibition of surface phagocytosis by capsular ‘slime layer’ of Pneumococcus Type III. J. Exp. Med. 90, 85.CrossRefGoogle ScholarPubMed