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Host specificity of and cross-immunity between two strains of Heligmosomoides polygyrus

Published online by Cambridge University Press:  06 April 2009

R.J. Quinnell ,
J. M. Behnke  and
A. E. Keymer
R.J. Quinnell
Affiliation:
Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS
J. M. Behnke
Affiliation:
Department of Zoology, University of Nottingham, University Park, Nottingham NG7 2RD
A. E. Keymer
Affiliation:
Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS
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Extract

The infectivity of wild and laboratory strains of Heligmosomoides polygyrus (Nematospiroides dubius) in laboratory mice and in three species of wild British rodent was compared. Wild strains, of the subspecies H. p. polygyrus, were isolated from wild caught Apodemus sylvaticus. Only very low-level infections of the wild strains became established in laboratory mice. Similar worm burdens of the laboratory strain became established in laboratory mice and A. sylvaticus, although infections in A. sylvaticus were more short lived. Cortisone treatment of hosts increased the establishment and survival of the heterologous worm strain to that of the homologous strain. In contrast, neither strain of parasite established in Clethrionomys glareolus or Microtus agrestis, and cortisone treatment of C. glareolus did not increase establishment. Infection of laboratory mice with the wild-strain parasite induced significant immunity to a challenge infection with the laboratory strain.

Keywords

Heligmosomoides polygyrusNematospiroides dubiusApodemus sylvaticusClethrionomys glareolusMicrotus agrestisinfectioninfectivityhost specificityNematodaimmunity
Type
Research Article
Information
Parasitology , Volume 102 , Issue 3 , June 1991 , pp. 419 - 427
Copyright
Copyright © Cambridge University Press 1991

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