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The evolution of acquired immunity to parasites

Published online by Cambridge University Press:  06 April 2009

N. A. Mitchison
Affiliation:
Imperial Cancer Research Fund, Tumour Immunology Unit, University College London, Gower Street, London WC1E 6BT

Summary

Evolutionary pressures exerted by parasites on the immune system, and vice versa, are surveyed from a speculative viewpoint. New information is presented about the possible channelling of suppression by MHC Class II genes in the mouse, where a novel pattern of dominant unresponsiveness mediated by H-2Ab is described. In addition, the hypothesis is advanced that phosphatidyl–inositol anchorage on the surface of parasites may represent a novel evasion mechanism, in which the spread of the immune response by epitope linkage is inhibited by host phospholipase.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1990

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