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The evolution of acquired immunity to parasites
Published online by Cambridge University Press: 06 April 2009
Summary
Evolutionary pressures exerted by parasites on the immune system, and vice versa, are surveyed from a speculative viewpoint. New information is presented about the possible channelling of suppression by MHC Class II genes in the mouse, where a novel pattern of dominant unresponsiveness mediated by H-2Ab is described. In addition, the hypothesis is advanced that phosphatidyl–inositol anchorage on the surface of parasites may represent a novel evasion mechanism, in which the spread of the immune response by epitope linkage is inhibited by host phospholipase.
- Type
- Research Article
- Information
- Parasitology , Volume 100 , Issue S1: Symposia of the British Society for Parasitology Volume 27:The evolutionary biology of parasitism , June 1990 , pp. S27 - S34
- Copyright
- Copyright © Cambridge University Press 1990
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