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Evidence for the involvement of a bone marrow-derived cell population in the immune expulsion of Trichinella spiralis

Published online by Cambridge University Press:  06 April 2009

D. Wakelin  and
Margaret M. Wilson
D. Wakelin
Affiliation:
Wellcome Laboratories for Experimental Paraistology, University of Glasgow, Bearsden Road, Bearsden, Glasgow G61 1QH
Margaret M. Wilson
Affiliation:
Wellcome Laboratories for Experimental Paraistology, University of Glasgow, Bearsden Road, Bearsden, Glasgow G61 1QH
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Extract

When mice were irradiated immediately before infection with Trichinella spiralis there was a profound and long-lasting interference with their ability to expel adult worms from the intestine. Irradiation given after the fifth day of infection was progressively less effective in this respect. The ability to expel worms was not restored when mesenteric lymph node cells (MLNC) were transferred (a) on the day of infection in mice irradiated one day previously, or (b) on day 7 of an infection in mice irradiated on day 6, even though the MLNC transferred immunity to intact recipients. Transfer of bone marrow (BM) alone was also without effect. However, worm explusion was restored if, following irradiation and injection of BM, 10 days were allowed for BM differentiation before transfer of MLNC. This restoration was effective even after lethal levels of irradiation and was clearly dependent upon a donor-derived BM component cooperating with, or responding to, the activity of the transferred MLNC. The possibility that the BM component is non-lymphoid in nature is discussed.

Type
Research Article
Information
Parasitology , Volume 74 , Issue 3 , June 1977 , pp. 225 - 234
Copyright
Copyright © Cambridge University Press 1977

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References

Campbell, P. A., Martens, B. L., Cooper, H. R. & McClatchy, J. K. (1974). Requirement for bone marrow-derived cells in resistance to Listeria. Journal of Immunology 112, 1407–14.CrossRefGoogle ScholarPubMed
Cline, M. J. (1975). The White Cell. Cambridge, Massachusetts: Harvard University Press.Google Scholar
Dineen, J. K. & Kelly, J. D. (1973). Explusion of Nippostrongylus brasiliensis from the intestine of rats: the role of a cellular component derived from the bone marrow. International Archives of Allergy and Applied Immunology 45, 759–66.CrossRefGoogle Scholar
Gore, R. W., Burger, H-J. & Sadun, E. H. (1973). Humoral and cellular factors in the resistance of rats to Trichinella spiralis. In Trichinellosis (ed. Kim, C. W.), pp. 367–82. New York: Intext Educational Publishers.Google Scholar
Hahn, H. (1975). Requirement for a bone marrow-derived component in the expression of cell-mediated antibacterial immunity. Infection and Immunity 11, 949–59.CrossRefGoogle ScholarPubMed
Keller, R. & keist, R. (1972). Protective immunity to Nippostrongylus brasiliensis in the rat: central role of the lymphocyte in worm expulsion. Immunology 22, 767–73.Google ScholarPubMed
Kelly, J. D., Dineen, J. K. & Love, R. J. (1973). Expulsion of Nippostrongylus brasiliensis from the intestine of rats: evidence for a third component in the rejection mechanism. International Archives of Allergy and Applied Immunology 45, 767–79.CrossRefGoogle ScholarPubMed
Larsh, J. E. Jr. & Race, G. J. (1975). Allergic inflammation as a hypothesis for the expulsion of worms from tissues: a review. Experimental Parasitology 37, 251–66.CrossRefGoogle ScholarPubMed
Larsh, J. E., JrGoulson, H. T.. & Weatherly, N. F. (1964). Studies on delayed (cellular) hypersensitivity in mice infected with Trichinella spiralis. I. Transfer of lymph node cells. Journal of the Elisha Mitchell Scientific Society 80, 133–5.Google Scholar
Love, R. J., Ogilvie, B. M. & McLaren, D. J. (1976). The immune mechanism which expels the intestinal stage of Trichinella spiralis from rats. Immunology 30, 7–16.Google ScholarPubMed
Ogilvie, B. M. & Love, R. J. (1974). Cooperation between antibodies and cells in immunity to a nematode parasite. Transplantation Reviews 19, 147–68.Google ScholarPubMed
Taliaferro, W. H., Taliaferro, L. G. & Jaroslow, B. N. (1964). Radiation and Immune Mechanisms. New York and London: Academic Press.Google Scholar
Wakelin, D. (1975). Immune expulsion of Trichuris muris from the mice during a primary infection: analysis of the components involved. Parasiology 70, 397–405.CrossRefGoogle ScholarPubMed
Wakelin, D. & Lloyd, M. (1976 a). Accelerated expulsion of adult Trichinella spiralis in mice given lymphoid cells and serum from infected donors. Parasiology 72, 307–15.CrossRefGoogle ScholarPubMed
Wakelin, D. & Lloyd, M. (1976 b). Immunity to primary and challenge infections Trichinella spiralis in mice: a re-examination of conventional parameters. Paratisology 72, 173–82.Google ScholarPubMed
Wakelin, D. & Selby, G. R. (1974). Thymus-dependency of the immune response of mice to a primary infection with the nematode Trichuris muris. International Journal for parasitology 4, 657–61.CrossRefGoogle ScholarPubMed
Wakelin, D. & Selby, G. R. (1976). Immune expulsion of Trichuris muris from resistant mice: suppression by irradiation and restoration by transfer of lymphoid cells. Parasitology 72, 41–50.CrossRefGoogle ScholarPubMed
Wakelin, D. & Wilson, M. M. (1977). Transfer of immunity to Trichinella spiralis in the mouse with mesenteric lymph node cells. Time of appearence of effective cells in donors and expression of immunity in recipients. Parasitology 74, 215–24.CrossRefGoogle ScholarPubMed
Yarinsky, A. (1962). The influence of X-irradiation on the immunity of mice to infection with Trichinella spiralis. Journal of the Elisha Mitchell Scientific Society 78, 29–43.Google Scholar