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Evasion of the oxidative microbicidal activity of human monocytes by trypomastigotes of Trypanosoma dionisii

Published online by Cambridge University Press:  06 April 2009

Kareen J. I. Thorne ,
Audrey M. Glauert ,
Rosamund J. Svvennsen ,
H. Thomas ,
Jane Morris  and
D. Franks
Kareen J. I. Thorne
Affiliation:
Strangeways Research Laboratory, Worts' Causeway, Cambridge CB1 4RN
Audrey M. Glauert
Affiliation:
Strangeways Research Laboratory, Worts' Causeway, Cambridge CB1 4RN
Rosamund J. Svvennsen
Affiliation:
2Department of Pathology, University of Cambridge, Cambridge CB2 1QP
H. Thomas
Affiliation:
2Department of Pathology, University of Cambridge, Cambridge CB2 1QP
Jane Morris
Affiliation:
2Department of Pathology, University of Cambridge, Cambridge CB2 1QP
D. Franks
Affiliation:
2Department of Pathology, University of Cambridge, Cambridge CB2 1QP
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Summary

Trypomastigotes of Trypanosoma dionisii, a stercorarian trypanosome from bats, are effectively killed by neutrophils from human peripheral blood but are less sensitive to the cytotoxic action of human monocytes. The mechanism of killing appears to involve peroxidase and hydrogen peroxide. Trypomastigotes are as effective as epimastigotes in inducing the formation of hydrogen peroxide by effector cells. They are, however, less sensitive than epimastigotes to the cytotoxic effect of peroxidase and hydrogen peroxide. They are therefore susceptible to the high concentrations of peroxidase found in the phagosome of the neutrophil, but resist the lower levels encountered in monocytes.

Type
Research Article
Information
Parasitology , Volume 83 , Issue 1 , August 1981 , pp. 115 - 123
Copyright
Copyright © Cambridge University Press 1981

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References

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