Hostname: page-component-586b7cd67f-vdxz6 Total loading time: 0 Render date: 2024-11-24T11:39:52.766Z Has data issue: false hasContentIssue false
  • English
  • Français

Eimeria tenella: experimental studies on the development of resistance to amprolium, clopidol and methyl benzoquate

Published online by Cambridge University Press:  06 April 2009

H. D. Chapman
H. D. Chapman
Affiliation:
Houghton Poultry Research Station, Houghton, Huntingdon, Cambs. PE17 2DA
Get access Rights & Permissions [Opens in a new window]

Summary

The development of resistance by the Houghton strain of Eimeria tenella to the anticoccidial drugs amprolium, clopidol and methyl benzoquate has been studied. Resistance to amprolium and clopidol developed more readily in experiments where a large number of coccidia were exposed to the drug, either by increasing the number of oocysts in the inoculum or by increasing the number of birds in the group. When 45 birds were given 2·0 × 106 oocysts, resistance to amprolium and clopidol appeared after 6 and 7 passages respectively. In previous experiments, under similar conditions, resistance to robenidine developed after 6 passages, suggesting little difference between these three drugs. Resistance to amprolium and clopidol arose gradually as the concentration of drug was increased, but resistance to methyl benzoquate appeared in a single step from sensitivity to high-level resistance. Both amprolium and clopidol-resistant lines showed an 8-fold reduction in drug sensitivity. Attempts to measure the degree of resistance by calculation of the ED50 were unsuccessful.

Type
Research Article
Information
Parasitology , Volume 76 , Issue 2 , April 1978 , pp. 177 - 183
Copyright
Copyright © Cambridge University Press 1978

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Bryson, V. & Szybalski, W. (1955). Microbial drug resistance. Advances in Genetics 7, 1–46.CrossRefGoogle ScholarPubMed
Chapman, H. D. (1975). Eimeria tenella in. chickens: development of resistance to quinolone anticoccidial drugs. Parasitology 71, 41–9.CrossRefGoogle ScholarPubMed
Chapman, H. D. (1976). Eimeria tenella: experimental studies on the development of resistance to robenidine. Parasitology 73, 265–73.CrossRefGoogle ScholarPubMed
Demerec, M. (1945). Production of staphy lococcus strains resistant to various concentrations of penicillin. Proceedings of the National Academy of Science 31, 16–24.CrossRefGoogle Scholar
Franklin, T. J. & Snow, G. A. (1975). Biochemistry of Antimicrobial Action. London: Chapman and Hall Ltd.CrossRefGoogle Scholar
Hawking, F. & Walker, P. J. (1966). Analysis of the development of arsenical resistance in trypanosomes in vitro. Experimental Parasitology 18, 63–86.CrossRefGoogle ScholarPubMed
McManus, E. C., Campbell, W. C. & Cuckler, A. C. (1968). Development of resistance to quinolone coccidiostats under field and laboratory conditions. Journal of Parasitology 54, 1190–3.CrossRefGoogle Scholar
McLoughlin, D. K. (1970). Efficacy of buquinolate against ten strains of Eimeria tenella and the development of a resistant strain. Avian Diseases 14, 126–30.CrossRefGoogle ScholarPubMed
McLoughlin, D. K. & Chute, M. B. (1971). Efficacy of decoquinate against eleven strains of Eimeria tenella and development of a decoquinate resistant strain. Avian Diseases 15, 342–5.Google Scholar
McLoughlin, D. K. & Chute, M. B. (1973 a). Efficacy of nequinate against thirteen strains of Eimeria tenella and the development of a nequinate resistant strain. Avian Diseases 17, 717–21.CrossRefGoogle ScholarPubMed
McLoughlin, D. K. & Chute, M. B. (1973 b). Efficacy of clopidol against twelve strains of Eimeria tenella and the development of a clopidol resistant strain. Avian Diseases 17, 425–9.CrossRefGoogle ScholarPubMed
McLoughlin, D. K. & Gardiner, J. L. (1968). Drug resistance in Eimeria tenella. VI. The experimental development of an amprolium resistant strain. Journal of Parasitology, 54, 582–4.Google Scholar
Norton, C. C. & Joyner, L. P. (1975). The development of drug resistant strains of Eimeria maxima in the laboratory. Parasitology 71, 153–65.CrossRefGoogle ScholarPubMed
Peters, W. (1965). Drug resistance in Plasmodium berghei Vincke and Lips 1948. I. Chloroquine resistance. Experimental Parasitology, 17, 80–9.CrossRefGoogle ScholarPubMed
Ryley, J. F. & Betts, M. J. (1973). Chemotherapy of chicken coccidiosis. Advances in Pharmacology and Chemotherapy 11, 221–93.CrossRefGoogle ScholarPubMed
Schoenfeld, C., Most, H. & Entner, N. (1974). Chemotherapy of rodent malaria; transfer of resistance versus mutation. Experimental Parasitology 36, 265–77.CrossRefGoogle Scholar
Weppelman, R. M., Battaglia, J. A. & Wang, C. C. (1977). Eimeria tenella: the selection and frequency of drug-resistant mutants. Experimental Parasitology 42, 56–66.CrossRefGoogle ScholarPubMed