Hostname: page-component-cd9895bd7-8ctnn Total loading time: 0 Render date: 2024-12-26T00:51:23.705Z Has data issue: false hasContentIssue false
  • English
  • Français

Effects of Spirometra erinacei plerocercoids on the growth of Snell dwarf mice

Published online by Cambridge University Press:  06 April 2009

K. Shiwaku ,
K. Hirai ,
M. Torii  and
T. Tsuboi
K. Shiwaku
Affiliation:
Department of Parasitology, Ehime University School of Medicine, Shigenobu-cho, Ehime 791–02, Japan
K. Hirai
Affiliation:
Department of Parasitology, Ehime University School of Medicine, Shigenobu-cho, Ehime 791–02, Japan
M. Torii
Affiliation:
Department of Parasitology, Ehime University School of Medicine, Shigenobu-cho, Ehime 791–02, Japan
T. Tsuboi
Affiliation:
Department of Parasitology, Ehime University School of Medicine, Shigenobu-cho, Ehime 791–02, Japan
Get access Rights & Permissions [Opens in a new window]

Summary

Snell normal and dwarf mice were infected with Spirometra erinacei plerocercoids collected in Japan, to investigate the relationship between the growth-promoting effects of plerocercoids and the growth hormone releasing factor and the somatostatin – growth hormone – somatomedin axis in the host. Infection with plerocercoids caused increases in body weight and weights of muscle, liver, spleen and heart in the normal male mice, and increases in the head–body length, body weight and weights of muscle, liver, spleen, kidney and heart in the normal female mice, but did not increase the weight of the fat pad. Infection with plerocercoids caused increases in body weights and weights of muscle, liver and spleen in the male dwarf mice, and increases in the head–body length, body weight and weights of muscle, liver, spleen and kidney in the female dwarf mice. These observations suggest that plerocercoids promote the growth of dwarf mice as well as normal mice. As the dwarfism of Snell mice is due to a defective anterior pituitary gland, it seems that plerocercoids do not stimulate secretion of growth hormone from the pituitary. Accordingly, it seems to be more probable that the larvae secrete a growth hormone-like substance.

Type
Research Article
Information
Parasitology , Volume 87 , Issue 3 , December 1983 , pp. 447 - 453
Copyright
Copyright © Cambridge University Press 1983

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Bartke, A. (1965). The response of two types of dwarf mice to growth hormone, thyrotropin, and thyroxine. General and Comparative Endocrinology 5, 418–26.CrossRefGoogle ScholarPubMed
van Bull, S. & Van den Brande, J. L. (1979). Effect of growth hormone and peptide fractions containing somatomedin activity on growth and cartilage metabolism of Snell dwarfmouse. Acta Endocrinologica 92, 242–57.Google Scholar
Garland, J. T., Ruegamer, W. R. & Daughaday, W. H. (1971). Induction of sulfation factor activity by infection of hypophysectomized rats with Spirometra mansonoides. Endocrinology 88, 924–7.CrossRefGoogle ScholarPubMed
Hirai, K., Nishida, H., Shiwaku, K. & Okuda, H. (1978). Studies of the plerocercoid growth factor of Spirometra erinacei (Rudolphi, 1819) with special reference to the effect on lipid mobilization in vitro. Japanese Journal of Parasitology 27, 527–33.Google Scholar
Mueller, J. F. (1963). Parasite-induced weight gain in mice. Annals of the New York Academy of Sciences 133, 216–33.Google Scholar
Mueller, J. F. (1968). Growth stimulating effect of experimental sparganosis in thyroidectomized and hypophysectomized rats, and comparative activity of different species of Spirometra. Journal of Parasitology 54, 795–801.CrossRefGoogle ScholarPubMed
Mueller, J. F. (1970). Quantitative relationship between stimulus and response in the growth-promoting effect of Spirometra mansonoides spargana on the hypophysectomized rat. Journal of Parasitology 56, 840–2.CrossRefGoogle Scholar
Mueller, J. F. (1972). Further studies on sparganum growth factor in the hypophysectomized rat: response to large numbers of spargana. Journal of Parasitology 58, 438–43.CrossRefGoogle ScholarPubMed
Mueller, J. F. (1974). The biology of Spirometra. Journal of Parasitology 60, 3–14.CrossRefGoogle ScholarPubMed
Noguchi, T., Sugisaki, T., Watanabe, M., Tsukada, Y. & Tanabe, M. (1980). Brain development and growth factors. In Growth and Growth Factors (ed. Shizume, K. & Takano, K.), pp 203–30. Tokyo: University of Tokyo Press.Google Scholar
Shiwaku, K. & Hirai, K. (1982). Growth-promoting effect of Spirometra erinacei (Rudolphi, 1819) plerocercoids in young mice. Japanese Journal of Parasitology 31, 183–93.Google Scholar
Shiwaku, K., Hirai, K. & Torii, M. (1982). Growth-promoting effect of Spirometra erinacei (Rudolphi, 1819) plerocercoids in mature mice. Relationship between number of infected plerocercoids and growth-promoting effect. Japanese Journal of Parasitology 31, 353–60. (In Japanese.)Google Scholar
Sinha, Y. N., Salocks, C. B. & Vanderlaan, W. P. (1975). Pituitary and serum concentration of prolactin and GH in Snell dwarf mice. Proceedings of the Society for Experimental Biology and Medicine 150, 207–10.CrossRefGoogle ScholarPubMed
Snell, G. D. (1929). Dwarf, a new Mendelian recessive character of the house mouse. Proceedings of the National Academy of Science, USA 15, 733–4.CrossRefGoogle ScholarPubMed
Steelman, S. L., Glitzer, M. S., Ostlind, D. A. & Mueller, J. F. (1971). Biological properties of the growth hormone like factor from the plerocercoid of Spirometra mansonoides. Recent Progress in Hormone Research 27, 97–120.Google Scholar
Steelman, S. L., Morgan, E. R., Cuccaro, A. J. & Glitzer, M. S. (1970). Growth hormone like activity in hypophysectomized rats implanted with Spirometra mansonoides spargana. Proceedings of the Society for Experimental Biology and Medicine 133, 269–73.CrossRefGoogle ScholarPubMed
Tsushima, T., Friesen, H. G., Chang, T. W. & Raben, M. S. (1974). Identification of sparganum growth factor by a radioreceptor assay for growth hormone. Biochemical and Biophysical Research Communications 59, 1062–8.CrossRefGoogle ScholarPubMed