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The effect of sulphadiazine, proguanil and 2:4-diamino-6:7-diisopropylpteridine upon gametocyte production in Plasmodium gallinaceum (Brumpt, 1935)

Published online by Cambridge University Press:  06 April 2009

Ann Bishop
Ann Bishop
Affiliation:
The Molteno Institute, University of Cambridge
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Extract

In strains of Plasmodium gallinaceum passaged by blood-inoculation, through young birds treated with small, but effective doses of proguanil, sulphadiazine or 2:4-diamino-6:7-diisopropylpteridine, the numbers of gametocytes produced were much greater than in the parent strain passaged by the same method.

The effect of the drugs upon gametocyte production appears to be a long term one, since no change in gametocyte numbers was observed in birds treated with proguanil or sulphadiazine for only a few days.

The relationship of these drugs to nuclear division and the synthesis of nucleic acids is discussed in the light of the observed increase in gametocyte-production in drug-treated strains of P. gallinaceum.

Type
Research Article
Information
Parasitology , Volume 44 , Issue 1-2 , May 1954 , pp. 120 - 131
Copyright
Copyright © Cambridge University Press 1954

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