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Effect of essential oils on Leishmania amazonensis: a systematic review

Published online by Cambridge University Press:  03 August 2020

Célia Eliane de Lara da Silva ,
Jully Oyama ,
Fabiana Borges Padilha Ferreira Open the ORCID record for Fabiana Borges Padilha Ferreira [Opens in a new window] ,
Marielle Priscila de Paula Lalucci-Silva ,
Tarcísio Vitor Augusto Lordani Open the ORCID record for Tarcísio Vitor Augusto Lordani [Opens in a new window] ,
Rogério Cesar de Lara da Silva Open the ORCID record for Rogério Cesar de Lara da Silva [Opens in a new window] ,
Mariana de Souza Terron Monich ,
Jorge Juarez Vieira Teixeira Open the ORCID record for Jorge Juarez Vieira Teixeira [Opens in a new window]  and
Maria Valdrinez Campana Lonardoni Open the ORCID record for Maria Valdrinez Campana Lonardoni [Opens in a new window]
Célia Eliane de Lara da Silva
Affiliation:
Graduate Program in Bioscience and Physiopathology, Department of Clinical Analysis and Biomedicine, State University of Maringa, Maringá, Paraná, Brazil
Jully Oyama
Affiliation:
Graduate Program in Bioscience and Physiopathology, Department of Clinical Analysis and Biomedicine, State University of Maringa, Maringá, Paraná, Brazil
Fabiana Borges Padilha Ferreira
Affiliation:
Graduate Program in Health Sciences, Center of Health Sciences, State University of Maringa, Maringá, Paraná, Brazil
Marielle Priscila de Paula Lalucci-Silva
Affiliation:
Graduate Program in Bioscience and Physiopathology, Department of Clinical Analysis and Biomedicine, State University of Maringa, Maringá, Paraná, Brazil
Tarcísio Vitor Augusto Lordani
Affiliation:
Graduate Program in Bioscience and Physiopathology, Department of Clinical Analysis and Biomedicine, State University of Maringa, Maringá, Paraná, Brazil
Rogério Cesar de Lara da Silva
Affiliation:
Chemical Technology Development Center – CDTEQ, State University of Mato Grosso do Sul, Naviraí, Mato Grosso do Sul, Brazil
Mariana de Souza Terron Monich
Affiliation:
Graduate Program in Health Sciences, Center of Health Sciences, State University of Maringa, Maringá, Paraná, Brazil
Jorge Juarez Vieira Teixeira
Affiliation:
Graduate Program in Bioscience and Physiopathology, Department of Clinical Analysis and Biomedicine, State University of Maringa, Maringá, Paraná, Brazil
Maria Valdrinez Campana Lonardoni*
Affiliation:
Graduate Program in Bioscience and Physiopathology, Department of Clinical Analysis and Biomedicine, State University of Maringa, Maringá, Paraná, Brazil Graduate Program in Health Sciences, Center of Health Sciences, State University of Maringa, Maringá, Paraná, Brazil
*
Author for correspondence: Maria Valdrinez Campana Lonardoni, E-mail: [email protected]
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Abstract

This systematic review investigated the evidence for the therapeutic potential of essential oils (EOs) against Leishmania amazonensis. We searched available scientific publications from 2005 to 2019 in the PubMed and Web of Science electronic databases, according to PRISMA statement. The search strategy utilized descriptors and free terms. The EOs effect of 35 species of plants identified in this systematic review study, 45.7% had half of the maximal inhibitory concentration (IC50) 10 < IC50 ⩽ 50 μg mL−1 and 14.3% had a 10 < IC50μg mL−1 for promastigote forms of L. amazonensis. EOs from Cymbopogon citratus species had the lowest IC50 (1.7 μg mL−1). Among the plant species analyzed for activity against intracellular amastigote forms of L. amazonensis, 39.4% had an IC50 10 < IC50 ⩽ 50 μg mL−1, and 33.3% had an IC50 10 < IC50μg mL−1. Aloysia gratissima EO showed the lowest IC50 (0.16 μg mL−1) for intracellular amastigotes. EOs of Chenopodium ambrosioides, Copaifera martii and Carapa guianensis, administered by the oral route, were effective in reducing parasitic load and lesion volume in L. amazonensis-infected BALB/c mice. EOs of Bixa orellana and C. ambrosioides were effective when administered intraperitoneally. Most of the studies analyzed in vitro and in vivo for the risk of bias showed moderate methodological quality. These results indicate a stimulus for the development of new phytotherapy drugs for leishmaniasis treatment.

Keywords

Essential oilsLeishmania amazonensisphytotherapyplant oils
Type
Review Article
Information
Parasitology , Volume 147 , Issue 13 , November 2020 , pp. 1392 - 1407
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Copyright
Copyright © The Author(s) 2020. Published by Cambridge University Press

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References

Alvar, J, Velez, ID, Bern, C, Herrero, M, Desjeux, P, Cano, J, Jannin, J and den Boer, M (2012) Leishmaniasis worldwide and global estimates of its incidence. PLoS ONE 7, e35671.CrossRefGoogle ScholarPubMed
Andrade, MA, Azevedo, CD, Motta, FN, Dos Santos, ML, Silva, CL, de Santana, JM and Bastos, IMD (2016) Essential oils: in vitro activity against Leishmania amazonensis, cytotoxicity and chemical composition. BMC Complementary and Alternative Medicine 16, 444.CrossRefGoogle ScholarPubMed
Andrade, PM, Melo, DC, Alcoba, AET, Ferreira Junior, WG, Pagotti, MC, Magalhaes, LG, Santos, T, Crotti, AEM, Alves, CCF and Miranda, MLD (2018) Chemical composition and evaluation of antileishmanial and cytotoxic activities of the essential oil from leaves of Cryptocarya aschersoniana Mez. (Lauraceae Juss.). Anais da Academia Brasileira de Ciencias 90, 2671–2678.Google Scholar
Bernuci, KZ, Iwanaga, CC, Fernadez-Andrade, CM, Lorenzetti, FB, Torres-Santos, EC, Faioes, VD, Goncalves, JE, do Amaral, W, Deschamps, C, Scodro, RB, Cardoso, RF, Baldin, VP and Cortez, DA (2016) Evaluation of chemical composition and antileishmanial and antituberculosis activities of essential oils of Piper species. Molecules 21, 1698. doi: 10.3390/molecules21121698CrossRefGoogle ScholarPubMed
Bosquiroli, LSS, Dos Santos Ferreira, AC, Farias, KS, da Costa, EC, Matos, MFC, Kadri, MCT, Rizk, YS, Alves, FM, Perdomo, RT, Carollo, CA and Pinto de Arruda, CC (2017) In vitro Antileishmania activity of sesquiterpene-rich essential oils from Nectandra species. Pharmaceutical Biology 55, 2285–2291.CrossRefGoogle ScholarPubMed
Brasil, Ministério da Saúde e Anvisa (2015) Monografia da espécie Matricaria chamomilla L. (= Chamomilla recutita (L.) Rauschert, camomila). https://portalarquivos2.saude.gov.br/images/pdf/2017/setembro/11/Monografia-Camomila.pdf (Accessed 08 June 2020).Google Scholar
Brasil, Ministério da Saúde (2017). Manual de Vigilância da Leishmaniose Tegumentar Americana. Secretaria de Vigilância em Saúde. 2. Ed. http://bvsms.saude.gov.br/bvs/publicacoes/manual_vigilancia_leishmaniose_tegumentar.pdf (Accessed 23 November 2019).Google Scholar
Burza, S, Croft, SL and Boelaert, M (2018) Leishmaniasis. Lancet (London, England) 392, 951–970.CrossRefGoogle ScholarPubMed
Cardoso, BM, de Mello, TF, Lopes, SN, Demarchi, IG, Lera, DS, Pedroso, RB, Cortez, DA, Gazim, ZC, Aristides, SM, Silveira, TG and Lonardoni, MV (2015) Antileishmanial activity of the essential oil from Tetradenia riparia obtained in different seasons. Memorias do Instituto Oswaldo Cruz 110, 1024–1034.CrossRefGoogle ScholarPubMed
Carvalho, CE, Sobrinho-Junior, EP, Brito, LM, Nicolau, LA, Carvalho, TP, Moura, AK, Rodrigues, KA, Carneiro, SM, Arcanjo, DD, Cito, AM and Carvalho, FA (2017) Anti-leishmania activity of essential oil of Myracrodruon urundeuva (Engl.) Fr. All.: composition, cytotoxity and possible mechanisms of action. Experimental Parasitology 175, 59–67.CrossRefGoogle ScholarPubMed
Ceole, LF, Cardoso, MDG and Soares, MJ (2017) Nerolidol, the main constituent of Piper aduncum essential oil, has anti-Leishmania braziliensis activity. Parasitology 144, 1179–1190.CrossRefGoogle ScholarPubMed
Clardy, J and Walsh, C (2004) Lessons from natural molecules. Nature 432, 829–837.CrossRefGoogle ScholarPubMed
Cos, P, Vlietinck, AJ, Berghe, DV and Maes, L (2006) Anti-infective potential of natural products: how to develop a stronger in Vitro ‘proof-of-concept’. Journal of Ethnopharmacology 106, 290–302.CrossRefGoogle Scholar
Costa, JML, Uthant, AA, CostaMl, EAN, Bezerril, AC and Barral, A (2009) Diffuse cutaneous leishmaniasis (DCL) in Brazil after 60 years of your first description. Gazeta Médica da Bahia 79, 19–24.Google Scholar
Cruz, GV, Pereira, PV, Patricio, FJ, Costa, GC, Sousa, SM, Frazao, JB, Aragao-Filho, WC, Maciel, MC, Silva, LA, Amaral, FM, Barroqueiro, ES, Guerra, RN and Nascimento, FR (2007) Increase of cellular recruitment, phagocytosis ability and nitric oxide production induced by hydroalcoholic extract from Chenopodium ambrosioides leaves. Journal of Ethnopharmacology 111, 148–154.CrossRefGoogle ScholarPubMed
da Silva, VD, Almeida-Souza, F, Teles, AM, Neto, PA, Mondego-Oliveira, R, Mendes Filho, NE, Taniwaki, NN, Abreu-Silva, AL, da Silva Calabrese, K and Mouchrek Filho, VE (2018) Chemical composition of Ocimum canum Sims. Essential oil and the antimicrobial, antiprotozoal and ultrastructural alterations it induces in Leishmania amazonensis promastigotes. Industrial Crops and Products 119, 201–208.CrossRefGoogle Scholar
da Silva Santos, E, Garcia, FP, Outuki, PM, Hoscheid, J, Nunes de Goes, PR, Cardozo-Filho, L, Nakamura, CV and Carvalho Cardoso, ML (2016) Optimization of extraction method and evaluation of antileishmanial activity of oil and nanoemulsions of Pterodon pubescens benth. fruit extracts. Experimental Parasitology 170, 252–260.CrossRefGoogle ScholarPubMed
de Cassia da Silveira, ESR, Lima, TC, da Nobrega, FR, de Brito, AEM and de Sousa, DP (2017) Analgesic-like activity of essential oil constituents: an update. International Journal of Molecular Sciences 18, 2352. doi: 10.3390/ijms18122392.CrossRefGoogle Scholar
de Lima, SC, Teixeira, MJ, Lopes, JE Jr, de Morais, SM, Torres, AF, Braga, MA, Rodrigues, RO, Santiago, GM, Martins, AC and Nagao-Dias, AT (2014) In vitro and in vivo leishmanicidal activity of Astronium fraxinifolium (Schott) and Plectranthus amboinicus (Lour.) Spreng against Leishmania (Viannia) braziliensis. Biomed Research International 2014, 848293.CrossRefGoogle ScholarPubMed
Demarchi, IG, Thomazella, MV, de Souza Terron, M, Lopes, L, Gazim, ZC, Cortez, DA, Donatti, L, Aristides, SM, Silveira, TG and Lonardoni, MV (2015) Antileishmanial activity of essential oil and 6,7-dehydroroyleanone isolated from Tetradenia riparia. Experimental Parasitology 157, 128–137.CrossRefGoogle ScholarPubMed
Demarchi, IG, Terron Mde, S, Thomazella, MV, Mota, CA, Gazim, ZC, Cortez, DA, Aristides, SM, Silveira, TG and Lonardoni, MV (2016) Antileishmanial and immunomodulatory effects of the essential oil from Tetradenia riparia (Hochstetter) Codd. Parasite Immunology 38, 64–77.CrossRefGoogle ScholarPubMed
de Medeiros, M, da Silva, AC, Cito, AM, Borges, AR, de Lima, SG, Lopes, JA and Figueiredo, RC (2011) In vitro antileishmanial activity and cytotoxicity of essential oil from Lippia sidoides Cham. Parasitology International 60, 237–241.CrossRefGoogle ScholarPubMed
de Santana, MF, Guimarães, AG, Chaves, DO, Silva, JC, Bonjardim, LR, de Lucca Júnior, W, Ferro, JN, Barreto Ede, O, dos Santos, FE, Soares, MB, Villarreal, CF, Quintans Jde, S and Quintans-Júnior, LJ (2015) The anti-hyperalgesic and anti-inflammatory profiles of p-cymene: evidence for the involvement of opioid system and cytokines. Pharmaceutical Biology 53, 1583–1590.CrossRefGoogle ScholarPubMed
Dhorm Pimentel de Moraes, AR, Tavares, GD, Soares Rocha, FJ, de Paula, E and Giorgio, S (2018) Effects of nanoemulsions prepared with essential oils of copaiba- and andiroba against Leishmania Infantum and Leishmania amazonensis infections. Experimental Parasitology 187, 12–21.CrossRefGoogle ScholarPubMed
Dias, CN, Rodrigues, KA, Carvalho, FA, Carneiro, SM, Maia, JG, Andrade, EH and Moraes, DF (2013) Molluscicidal and leishmanicidal activity of the leaf essential oil of Syzygium cumini (L.) SKEELS from Brazil. Chemistry and Biodiversity 10, 1133–1141.CrossRefGoogle ScholarPubMed
dos Santos, AO, Costa, MA, Ueda-Nakamura, T, Dias-Filho, BP, da Veiga-Junior, VF, de Souza Lima, MM and Nakamura, CV (2011) Leishmania amazonensis: effects of oral treatment with copaiba oil in mice. Experimental Parasitology 129, 145–151.CrossRefGoogle ScholarPubMed
Esperandim, VR, Silva Ferreira, D, Sousa Rezende, KC, Magalhães, LG, Souza, JM, Pauletti, PM, Januário, AH, Laurentz, RS, Bastos, JK, Símaro, GV, Cunha, WR and Andrade e Silva, ML (2013) In vitro antiparasitic activity and chemical composition of the essential oil obtained from the fruits of Piper cubeba. Planta Medica 79, 1653–1655.Google ScholarPubMed
Espinosa, OA, Serrano, MG, Camargo, EP, Teixeira, MMG and Shaw, JJ (2018) An appraisal of the taxonomy and nomenclature of trypanosomatids presently classified as Leishmania and Endotrypanum. Parasitology 145, 430–442.CrossRefGoogle ScholarPubMed
Fabri, RL, Coimbra, ES, Almeida, AC, Siqueira, EP, Alves, TM, Zani, CL and Scio, E (2012) Essential oil of Mitracarpus frigidus as a potent source of bioactive compounds. Anais da Academia Brasileira de Ciencias 84, 1073–1080.CrossRefGoogle ScholarPubMed
Faggion, CM Jr (2012). Guidelines for reporting pre-clinical in vitro studies on dental materials. The Journal of Evidence-based Dental Practice 12, 182–189.CrossRefGoogle ScholarPubMed
Ganesan, A (2008) The impact of natural products upon modern drug discovery. Current Opinion in Chemical Biology 12, 306–317.CrossRefGoogle ScholarPubMed
Garcia, M, Scull, R, Satyal, P, Setzer, WN and Monzote, L (2017) Chemical characterization, antileishmanial activity, and cytotoxicity effects of the essential oil from leaves of Pluchea carolinensis (Jacq.) G. Don. (Asteraceae). Phytotherapy Research 31, 1419–1426.CrossRefGoogle Scholar
Garcia, MCF, Soares, DC, Santana, RC, Saraiva, EM, Siani, AC, Ramos, MFS, Danelli, M, Souto-Padron, TC and Pinto-da-Silva, LH (2018) The in vitro antileishmanial activity of essential oil from Aloysia gratissima and guaiol, its major sesquiterpene against Leishmania amazonensis. Parasitology 145, 1219–1227.CrossRefGoogle ScholarPubMed
Gazim, ZC, Amorim, AC, Hovell, AM, Rezende, CM, Nascimento, IA, Ferreira, GA and Cortez, DA (2010) Seasonal variation, chemical composition, and analgesic and antimicrobial activities of the essential oil from leaves of Tetradenia riparia (Hochst.) Codd in southern Brazil. Molecules 15, 5509–5524.CrossRefGoogle ScholarPubMed
Gazim, ZC, Rodrigues, F, Amorin, AC, de Rezende, CM, Sokovic, M, Tesevic, V, Vuckovic, I, Krstic, G, Cortez, LE, Colauto, NB, Linde, GA and Cortez, DA (2014) New natural diterpene-type abietane from Tetradenia riparia essential oil with cytotoxic and antioxidant activities. Molecules 19, 514–524.CrossRefGoogle ScholarPubMed
Hajaji, S, Sifaoui, I, López-Arencibia, A, Reyes-Batlle, M, Jiménez, IA, Bazzocchi, IL, Valladares, B, Akkari, H, Lorenzo-Morales, J and Piñero, JE (2018) Leishmanicidal activity of α-bisabolol from Tunisian chamomile essential oil. Parasitology Research 117, 2855–2867.CrossRefGoogle ScholarPubMed
Hooijmans, CR, Rovers, MM, de Vries, RB, Leenaars, M, Ritskes-Hoitinga, M and Langendam, MW (2014) SYRCLE's risk of bias tool for animal studies. BMC Medical Research Methodology 14, 43.CrossRefGoogle ScholarPubMed
Houel, E, Gonzalez, G, Bessiere, JM, Odonne, G, Eparvier, V, Deharo, E and Stien, D (2015) Therapeutic switching: from antidermatophytic essential oils to new leishmanicidal products. Memorias do Instituto Oswaldo Cruz 110, 106–113.CrossRefGoogle ScholarPubMed
Igbinosa, EO, Uzunuigbe, EO, Igbinosa, IH, Odjadjare, EE, Igiehon, NO and Emuedo, OA (2013) In vitro assessment of antioxidant, phytochemical and nutritional properties of extracts from the leaves of Ocimum gratissimum (Linn). African Journal of Traditional, Complementary, and Alternative Medicines 10, 292–298.Google Scholar
Islamuddin, M, Sahal, D and Afrin, F (2014) Apoptosis-like death in Leishmania donovani promastigotes induced by eugenol-rich oil of Syzygium aromaticum. Journal of Medical Microbiology 63, 74–85.CrossRefGoogle ScholarPubMed
Jirku, M, Yurchenko, VY, Lukes, J and Maslov, DA (2012) New species of insect trypanosomatids from Costa Rica and the proposal for a new subfamily within the Trypanosomatidae. Journal of Eukaryotic Microbiology 59, 537–547.CrossRefGoogle ScholarPubMed
Lam, KS (2007) New aspects of natural products in drug discovery. Trends in Microbiology 15, 279–289.CrossRefGoogle ScholarPubMed
Laurella, LC, Cerny, N, Bivona, AE, Sanchez Alberti, A, Giberti, G, Malchiodi, EL, Martino, VS, Catalan, CA, Alonso, MR, Cazorla, SI and Sulsen, VP (2017) Assessment of sesquiterpene lactones isolated from Mikania plants species for their potential efficacy against Trypanosoma cruzi and Leishmania sp. PLoS Neglected Tropical Diseases 11, e0005929.CrossRefGoogle ScholarPubMed
Lopes, MV, Desoti, VC, Caleare Ade, O, Ueda-Nakamura, T, Silva, SO and Nakamura, CV (2012) Mitochondria superoxide anion production contributes to geranylgeraniol-induced death in Leishmania amazonensis. Evidence-Based Complementary and Alternative Medicine: ECAM 2012, 298320.CrossRefGoogle ScholarPubMed
Machado, M, Pires, P, Dinis, AM, Santos-Rosa, M, Alves, V, Salgueiro, L, Cavaleiro, C and Sousa, MC (2012) Monoterpenic aldehydes as potential anti-leishmania agents: activity of Cymbopogon citratus and citral on L. infantum, L. tropica and L. major. Experimental Parasitology 130, 223–231.CrossRefGoogle Scholar
Machado, GU, Prates, FV and Machado, PRL (2019) Disseminated leishmaniasis: clinical, pathogenic, and therapeutic aspects. Anais Brasileiros De Dermatologia 94, 9–16.CrossRefGoogle ScholarPubMed
Marques, AM, Barreto, AL, Batista, EM, Curvelo, JA, Velozo, LS, Moreira Dde, L, Guimaraes, EF, Soares, RM and Kaplan, MA (2010) Chemistry and biological activity of essential oils from Piper claussenianum (Piperaceae). Natural Product Communications 5, 1837–1840.CrossRefGoogle Scholar
Martins, MM, de Aquino, FJT, de Oliveira, A, do Nascimento, EA, Chang, R, Borges, MS, de Melo, GB, da Silva, CV, Machado, FC and de Morais, SAL (2015) Chemical composition, antimicrobial and antiprotozoal activity of essential oils from Vernonia brasiliana (Less) Druce (Asteraceae). Journal of Essential Oil Bearing Plants 18, 561–569.CrossRefGoogle Scholar
Moher, D, Shamseer, L, Clarke, M, Ghersi, D, Liberati, A, Petticrew, M, Shekelle, P and Stewart, LA (2015) Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Systematic Reviews 4, 1.CrossRefGoogle ScholarPubMed
Monzote, L, Montalvo, AM, Almanonni, S, Scull, R, Miranda, M and Abreu, J (2006) Activity of the essential oil from Chenopodium ambrosioides grown in Cuba against Leishmania amazonensis. Chemotherapy 52, 130–136.CrossRefGoogle ScholarPubMed
Monzote, L, Montalvo, AM, Scull, R, Miranda, M and Abreu, J (2007) Activity, toxicity and analysis of resistance of essential oil from Chenopodium ambrosioides after intraperitoneal, oral and intralesional administration in BALB/c mice infected with Leishmania amazonensis: a preliminary study. Biomedicine & Pharmacotherapy 61, 148–153.CrossRefGoogle ScholarPubMed
Monzote, L, Garcia, M, Montalvo, AM, Linares, R and Scull, R (2009) Effect of oral treatment with the essential oil from Chenopodium ambrosioides against cutaneous leishmaniasis in BALB/c mice, caused by Leishmania amazonensis. Forschende Komplementarmedizin (2006) 16, 334–338.CrossRefGoogle ScholarPubMed
Monzote, L, Garcia, M, Scull, R, Cuellar, A and Setzer, WN (2014a) Antileishmanial activity of the essential oil from Bixa orellana. Phytotherapy Research 28, 753–758.CrossRefGoogle Scholar
Monzote, L, Pastor, J, Scull, R and Gille, L (2014b) Antileishmanial activity of essential oil from Chenopodium ambrosioides and its main components against experimental cutaneous leishmaniasis in BALB/c mice. Phytomedicine: International Journal of Phytotherapy and Phytopharmacology 21, 1048–1052.CrossRefGoogle Scholar
Moura do Carmo, DF, Amaral, AC, Machado, GM, Leon, LL and Silva, JR (2012) Chemical and biological analyses of the essential oils and main constituents of Piper species. Molecules 17, 1819–1829.CrossRefGoogle ScholarPubMed
Nogueira, AO, Oliveira, YIS, Adjafre, BL, de Moraes, MEA and Aragao, GF (2019) Pharmacological effects of the isomeric mixture of alpha and beta amyrin from Protium heptaphyllum: a literature review. Fundamental & Clinical Pharmacology 33, 4–12.Google ScholarPubMed
Oliveira, I, Moragas Tellis, CJ, Chagas, M, Behrens, MD, Calabrese, KDS, Abreu-Silva, AL and Almeida-Souza, F (2018) Carapa guianensis Aublet (Andiroba) seed oil: chemical composition and antileishmanial activity of limonoid-rich fractions. Biomed Research International 2018, 5032816.CrossRefGoogle ScholarPubMed
Pelissari, DM, Cechinel, MP, de Sousa-Gomes, ML and Ferreira de Lima Junior, FE (2011) Treatment of visceral leishmaniasis and American cutaneous leishmaniasis in Brazil. Epidemiol Serv Saúde 20, 107–110.CrossRefGoogle Scholar
Pereira, PS, Barros, LM, Brito, AM, Duarte, AE and Maia, AJ (2014) Uso da Myracroduon urundeuva Allemão (aroeira do sertão) pelos agricultores no tratamento de doenças. Revista Cubana de Plantas Medicinales 19, 51–60.Google Scholar
Prerna, P and Vasudeva, N (2015) Origanum majorana L.–Phyto-pharmacological review. Indian Journal of Natural Products and Resources 6, 261–267.Google Scholar
Puatanachokchai, R, Kishida, H, Denda, A, Murata, N, Konishi, Y, Vinitketkumnuen, U and Nakae, D (2002) Inhibitory effects of lemon grass (Cymbopogon citratus, Stapf) extract on the early phase of hepatocarcinogenesis after initiation with diethylnitrosamine in male Fischer 344 rats. Cancer Letters 183, 9–15.CrossRefGoogle ScholarPubMed
Rodrigues, IA, Azevedo, MM, Chaves, FC, Bizzo, HR, Corte-Real, S, Alviano, DS, Alviano, CS, Rosa, MS and Vermelho, AB (2013) In vitro cytocidal effects of the essential oil from Croton cajucara (red sacaca) and its major constituent 7-hydroxycalamenene against Leishmania chagasi. BMC Complementary and Alternative Medicine 13, 249.CrossRefGoogle ScholarPubMed
Rodrigues, KA, Amorim, LV, Dias, CN, Moraes, DF, Carneiro, SM and Carvalho, FA (2015) Syzygium cumini (L.) Skeels essential oil and its major constituent alpha-pinene exhibit anti-Leishmania activity through immunomodulation in vitro. Journal of Ethnopharmacology 160, 32–40.CrossRefGoogle ScholarPubMed
Salehi, B, Zakaria, ZA, Gyawali, R, Ibrahim, SA, Rajkovic, J, Shinwari, ZK, Khan, T, Sharifi-Rad, J, Ozleyen, A, Turkdonmez, E, Valussi, M, Tumer, TB, Monzote Fidalgo, L, Martorell, M and Setzer, WN (2019) Piper species: a comprehensive review on their phytochemistry, biological activities and applications. Molecules 24, 1364. doi: 10.3390/molecules24071364CrossRefGoogle ScholarPubMed
Sanchez-Suarez, J, Riveros, I and Delgado, G (2013) Evaluation of the leishmanicidal and cytotoxic potential of essential oils derived from ten Colombian plants. Iranian Journal of Parasitology 8, 129–136.Google ScholarPubMed
Santin, MR, dos Santos, AO, Nakamura, CV, Dias Filho, BP, Ferreira, IC and Ueda-Nakamura, T (2009) In vitro activity of the essential oil of Cymbopogon citratus and its major component (citral) on Leishmania amazonensis. Parasitology Research 105, 1489–1496.CrossRefGoogle ScholarPubMed
Santos, AO, Ueda-Nakamura, T, Dias Filho, BP, Veiga Junior, VF, Pinto, AC and Nakamura, CV (2008) Effect of Brazilian copaiba oils on Leishmania amazonensis. Journal of Ethnopharmacology 120, 204–208.CrossRefGoogle ScholarPubMed
Santos, AO, Santin, AC, Yamaguchi, MU, Cortez, LE, Ueda-Nakamura, T, Dias-Filho, BP and Nakamura, CV (2010) Antileishmanial activity of an essential oil from the leaves and flowers of Achillea millefolium. Annals of Tropical Medicine & Parasitology 104, 475–483.CrossRefGoogle ScholarPubMed
Sen, R and Chatterjee, M (2011) Plant derived therapeutics for the treatment of Leishmaniasis. Phytomedicine: International Journal of Phytotherapy and Phytopharmacology 18, 1056–1069.CrossRefGoogle ScholarPubMed
Silveira, FT (2019) What makes mucosal and anergic diffuse cutaneous leishmaniases so clinically and immunopathogically different? A review in Brazil. Transactions of the Royal Society of Tropical Medicine and Hygiene 113, 505–516. doi: 10.1093/trstmh/trz037CrossRefGoogle Scholar
Silveira, FT, Lainson, R, Shaw, JJ, De Souza, AA, Ishikawa, EA and Braga, RR (1991) Cutaneous leishmaniasis due to Leishmania (Leishmania) amazonensis in Amazonian Brazil, and the significance of a negative Montenegro skin-test in human infections. Transactions of the Royal Society of Tropical Medicine and Hygiene 85, 735–738.CrossRefGoogle ScholarPubMed
Silveira, FT, Blackwell, JM, Ishikawa, EA, Braga, R, Shaw, JJ, Quinnell, RJ, Soong, L, Kima, P, McMahon-Pratt, D, Black, GF and Shaw, MA (1998) T cell responses to crude and defined leishmanial antigens in patients from the lower Amazon region of Brazil infected with different species of Leishmania of the subgenera Leishmania and Viannia. Parasite Immunology 20, 19–26.CrossRefGoogle ScholarPubMed
Tadic, V, Arsic, I, Zvezdanovic, J, Zugic, A, Cvetkovic, D and Pavkov, S (2017) The estimation of the traditionally used yarrow (Achillea millefolium L. Asteraceae) oil extracts with anti-inflammatory potential in topical application. Journal of Ethnopharmacology 199, 138–148.CrossRefGoogle ScholarPubMed
Teles, AM, Rosa, T, Mouchrek, AN, Abreu-Silva, AL, Calabrese, KDS and Almeida-Souza, F (2019) Cinnamomum zeylanicum, Origanum vulgare, and Curcuma longa essential oils: chemical composition, antimicrobial and antileishmanial activity. Evidence-Based Complementary and Alternative Medicine: ECAM 2019, 2421695.CrossRefGoogle ScholarPubMed
Terron-Monich, MS, Demarchi, IG, da Silva, PRF, Ramos-Milare, A, Gazim, ZC, Silveira, TGV and Lonardoni, MVC (2019) 6,7-Dehydroroyleanone Diterpene derived from Tetradenia riparia essential oil modulates IL-4/IL-12 release by macrophages that are infected with Leishmania amazonensis. Parasitology Research 118, 369–376.CrossRefGoogle ScholarPubMed
Ueda-Nakamura, T, Mendonca-Filho, RR, Morgado-Diaz, JA, Korehisa Maza, P, Prado Dias Filho, B, Aparicio Garcia Cortez, D, Alviano, DS, Rosa Mdo, S, Lopes, AH, Alviano, CS and Nakamura, CV (2006) Antileishmanial activity of Eugenol-rich essential oil from Ocimum gratissimum. Parasitology International 55, 99–105.CrossRefGoogle ScholarPubMed
Uritu, CM, Mihai, CT, Stanciu, GD, Dodi, G, Alexa-Stratulat, T, Luca, A, Leon-Constantin, MM, Stefanescu, R, Bild, V, Melnic, S and Tamba, BI (2018) Medicinal plants of the family Lamiaceae in pain therapy: a review. Pain Research & Management 2018, 7801543.CrossRefGoogle ScholarPubMed
Vendrametto, MC, Santos, AO, Nakamura, CV, Dias Filho, BP, Cortez, DA and Ueda-Nakamura, T (2010) Evaluation of antileishmanial activity of eupomatenoid-5, a compound isolated from leaves of Piper regnellii var. pallescens. Parasitology International 59, 154–158.CrossRefGoogle ScholarPubMed
Villalva, M, Jaime, L, Villanueva-Bermejo, D, Lara, B, Fornari, T, Reglero, G and Santoyo, S (2019) Supercritical anti-solvent fractionation for improving antioxidant and anti-inflammatory activities of an Achillea millefolium L. extract. Food Research International 115, 128–134.CrossRefGoogle ScholarPubMed
World Health Organization (2019) Leishmaniasis: Epidemiological Report of the Americas. http://iris.paho.org/xmlui/bitstream/handle/123456789/50505/Leishreport2019_eng.pdf?ua=1 (Accessed 10 December 2019).Google Scholar
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