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Dirofilaria aethiops Webber, 1955, a filarial parasite of monkeys II. Maintenance in the laboratory

Published online by Cambridge University Press:  06 April 2009

Frank Hawking  and
Winfrith A. F. Webber
Frank Hawking
Affiliation:
National Institute for Medical Research, London
Winfrith A. F. Webber
Affiliation:
National Institute for Medical Research, London
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Extract

1. An account is given of the stages of the life history of Dirofilaria aethiops which take place in the monkey and of the transmission of the infection in the laboratory.

2. The microfilariae exhibit nocturnal periodicity in the blood; the number of microfilariae at midday was usually less than 1% of the number at midnight.

3. Aëdes aegypti mosquitoes were fed on monkeys during the evening when there were many microfilariae in the blood. Larvae developed in these mosquitoes and they were ultimately transferred to fresh monkeys by injection of a saline suspension of mosquitoes and infective larvae. In this way six Cercopithecus aethiops and one Macaca mulatto, monkey were successfully infected; seven other Cercopithecus aethiops, one Cebus apella, and one Cercocebus monkey were inoculated, but the worms failed to establish themselves.

4. In the infected monkeys microfilariae appeared in the blood 11 months after the injection of infective larvae. The number of microfilariae then increased for 8–12 months. Subsequently, it decreased to one-tenth of the maximum in 2 years from the first appearance.

5. Post-mortem examination showed that the adult worms live in the fascial tissues on or between the muscle bundles, especially those of the thighs. Tissue reaction to the worms is slight and in these monkeys there was no other pathogenic effect of the infection.

6. Adult worms from three of the monkeys were transplanted to two normal monkeys. Microfilariae were found in the blood of one of these and persisted for over 2 years.

Type
Research Article
Information
Parasitology , Volume 45 , Issue 3-4 , November 1955 , pp. 378 - 387
Copyright
Copyright © Cambridge University Press 1955

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References

REFERENCES

Galliard, H. & Ngu, D.-V. (1947). Recherches sur la filariose. Choix d'une technique de numeration des microfilaires du sang. Ann. Parasit. hum. comp. 22, 158–63.CrossRefGoogle Scholar
Hawking, F. & Thurston, J. P. (1951). The periodicity of microfilariae. I. The distribution of microfilariae in the body. II. The explanation of its production. Trans. R. Soc. Trop. Med. Hyg. 45, 307–28, 329–40.CrossRefGoogle Scholar
Lane, C. (1948). Bancroftian filariasis. Biological mechanisms that underlie its periodicity and other of its clinical manifestations. Trans. R. Soc. Trop. Med. Hyg. 41, 717–84.Google ScholarPubMed
McFadzean, J. A. (1952). Investigations into the cause of microfilarial periodicity. Brit. Med. J. 24 05, i, 1106.CrossRefGoogle Scholar
Mellanby, H. (1956). The use of the mosquito Anopheles stephensi as a vector for the laboratory transmission of the nematode Dirofilaria repens. (To be published.)Google Scholar
Webber, W. A. F. (1955 a). The filarial parasites of primates: a review. I: Dirofilaria and Dipetalonema. Ann. Trop. Med. Parasitol. 49, 123–41.CrossRefGoogle ScholarPubMed
Webber, W. A. F. (1955 b). Dirofilaria aethiops Webber, 1955, a filarial parasite of monkeys: I. The morphology of the adult worms and microfilariae. Parasitology, 45, 369–77.CrossRefGoogle ScholarPubMed
Webber, W. A. F. (1955 c). Dirofilaria aethiops Webber, 1955, a filarial parasite of monkeys: III. The larval development in mosquitoes. Parasitology, 45, 388–400.CrossRefGoogle ScholarPubMed
Webber, W. A. F. & Hawking, F. (1955). Experimental maintenance of Dirofilaria repens and D. immitis in dogs. Exper. Parasitol. 4, 143–64.CrossRefGoogle Scholar