Hostname: page-component-cd9895bd7-dk4vv Total loading time: 0 Render date: 2024-12-27T17:57:41.426Z Has data issue: false hasContentIssue false
  • English
  • Français

The development of drug-resistant strains of Eimeria maxima in the laboratory

Published online by Cambridge University Press:  06 April 2009

C. C. Norton  and
L. P. Joyner
C. C. Norton
Affiliation:
Central Veterinary Laboratory, MAFF, New Haw, Weybridge, Surrey
L. P. Joyner
Affiliation:
Central Veterinary Laboratory, MAFF, New Haw, Weybridge, Surrey
Get access Rights & Permissions [Opens in a new window]

Extract

The development of strains of Eimeria maxima resistant to buquinolate, methyl benzoquate, clopidol, sulphaquinoxaline and robenidine is described. It was not possible to standardize a schedule of inoculations and drug administration, which would enable the development of resistance to the different drugs to be compared directly. Resistance developed most readily to the quinolones. One robenidine-resistant strain proved to be drug-dependent. Dinitolmide showed unusual effects upon sporogony and three attempts to develop resistance against this activity failed. Chicks previously immunized with the parent strain were completely protected against infection with the drug-resistant strains.

Type
Research Article
Information
Parasitology , Volume 71 , Issue 1 , August 1975 , pp. 153 - 165
Copyright
Copyright © Cambridge University Press 1975

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Hodgson, J. N., Ball, S. J., Ryan, K. C. & Warren, E. W. (1969). The incidence of drug resistant strains of Eimeria in chickens in Great Britain, 1966. British Veterinary Journal 125, 31–5.CrossRefGoogle Scholar
Joyner, L. P. (1969). Immunological variation between two strains of Eimeria acervulina. Parasitology 59, 725–32.CrossRefGoogle ScholarPubMed
Joyner, L. P. (1970). Coccidiosis: problems arising from the development of anticoccidial drug resistance. Experimental Parasitology 28, 122–8.CrossRefGoogle ScholarPubMed
Joyner, L. P. & Norton, C. C. (1970). The response of recently isolated strains of Eimeria meleagrimitis to chemotherapy. Research in Veterinary Science 11, 349–53.CrossRefGoogle ScholarPubMed
Joyner, L. P. & Norton, C. C. (1971). The recording and analysis of coccidiostatic activity; quinolone and pyridone compounds. Research in Veterinary Science 12, 80–8.CrossRefGoogle ScholarPubMed
Joyner, L. P. & Norton, C. C. (1974). Robenidine-dependence in a strain of Eimeria maxima. Parasitology 70, 47–51.CrossRefGoogle Scholar
Long, P. L. (1974). Experimental infection of chickens with two species of Eimeria isolated from the Malaysian Jungle fowl. Parasitology 69, 337–47.CrossRefGoogle ScholarPubMed
Long, P. L. & Rowell, J. G. (1958). Counting oocysts of chicken coccidia. Laboratory Practice 7, 515–18.Google Scholar
McLoughlin, D. K. (1970). Coccidiosis: Experimental analysis of drug resistance. Experimental Parasitology 28, 129–36.CrossRefGoogle ScholarPubMed
McManus, E. C., Campbell, W. C. & Cuckler, A. C. (1968). Development of resistance to quinolone coccidiostats under field and laboratory conditions. Journal of Parasitology 54, 1190–3.CrossRefGoogle Scholar
Norton, C. C. & Joyner, L. P. (1968). The freeze preservation of coccidia. Research in Veterinary Science 9, 598–600.CrossRefGoogle ScholarPubMed
Ryley, J. F. & Betts, M. J. (1973). ‘Chemotherapy of Chicken Coccidiosis’. In Advances in Pharmacology and Chemotherapy, Vol. 9, pp. 221–93. New York: Academic Press.Google Scholar
Warren, E. W., Ball, S. J. & Mackenzie, D. R. (1966). The incidence of drug-resistant strains of Eimeria species in chickens in Great Britain, 1964/65. British Veterinary Journal 122, 534–43.CrossRefGoogle Scholar
Williams, R. B. (1969). The persistence of drug resistance in strains of Eimeria species in broiler chickens following a change of coccidiostat. Research in Veterinary Science 10, 490–2.CrossRefGoogle ScholarPubMed