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Delayed tail loss during the invasion of mouse skin by cercariae of Schistosoma japonicum

Published online by Cambridge University Press:  24 October 2011

TING WANG ,
ZHENG-MING FANG ,
JIA-HUI LEI ,
FEI GUAN ,
WEN-QI LIU ,
ANN BARTLETT ,
PHIL WHITFIELD  and
YONG-LONG LI
TING WANG
Affiliation:
Department of Parasitology, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, China
ZHENG-MING FANG
Affiliation:
Department of Parasitology, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, China
JIA-HUI LEI
Affiliation:
Department of Parasitology, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, China
FEI GUAN
Affiliation:
Department of Parasitology, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, China
WEN-QI LIU
Affiliation:
Department of Parasitology, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, China
ANN BARTLETT
Affiliation:
School of Biomedical & Health Sciences, Pharmaceutical Sciences Division, King's College London, 150 Stamford Street, London SE1 9NN, UK
PHIL WHITFIELD
Affiliation:
School of Biomedical & Health Sciences, Pharmaceutical Sciences Division, King's College London, 150 Stamford Street, London SE1 9NN, UK
YONG-LONG LI*
Affiliation:
Department of Parasitology, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, China
*
*Corresponding author: Department of Parasitology, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, China. Tel: +86 27 83657670. E-mail: [email protected]
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Summary

A traditional assumption is that schistosome cercariae lose their tails at the onset of penetration. It has, however, recently been demonstrated that, for Schistosoma mansoni, cercarial tails were not invariably being shed as penetration took place and a high proportion of tails entered human skin under experimental conditions. This phenomenon was termed delayed tail loss (DTL). In this paper, we report that DTL also happens with S. japonicum cercariae during penetration of mouse skin. It occurred at all cercarial densities tested, from as few as 10 cercariae/2·25 cm2 of mouse skin up to 200 cercariae. Furthermore, it was demonstrated that there was a density-dependent increase in DTL as cercarial densities increased. No such density-dependent enhancement was shown for percentage attachment over the same cercarial density range.

Keywords

Schistosoma japonicumcercariaetail lossDTLattachment
Type
Research Article
Information
Parasitology , Volume 139 , Issue 2 , February 2012 , pp. 244 - 247
Copyright
Copyright © Cambridge University Press 2011

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References

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